Interaction effects of subjective memory impairment and ApoE4 genotype on episodic memory and hippocampal volume

2011 ◽  
Vol 41 (9) ◽  
pp. 1997-2006 ◽  
Author(s):  
N. Striepens ◽  
L. Scheef ◽  
A. Wind ◽  
D. Meiberth ◽  
J. Popp ◽  
...  
Keyword(s):  
Executive Function ◽  
Episodic Memory ◽  
Cognitive Performance ◽  
Memory Impairment ◽  
Hippocampal Volume ◽  
Interaction Effects ◽  
Subjective Memory ◽  
Positive Effects ◽  
Subjective Memory Impairment ◽  
Volumetric Measures

BackgroundThe apolipoprotein E4 allele (ApoE4) is an established genetic risk factor for Alzheimer's disease (AD). However, its effects on cognitive performance and brain structure in healthy individuals are complex. We investigated the effect of ApoE4 on cognitive performance and medial temporal lobe volumetric measures in cognitively unimpaired young elderly with and without subjective memory impairment (SMI), which is an at-risk condition for dementia.MethodAltogether, 40 individuals with SMI and 62 without were tested on episodic memory and on tasks of speed and executive function. All participants were ApoE genotyped. 21 subjects with SMI and 47 without received additional structural magnetic resonance imaging. Volumetric measures of the hippocampus, the entorhinal cortex and the amygdala were obtained manually.ResultsIn the SMI group, ApoE4 carriers performed worse on the episodic memory (p=0.049) and showed smaller left hippocampal volumes (p=0.030). In the individuals without SMI, the ApoE4 carriers performed better on episodic memory (p=0.018) and had larger right hippocampal volumes (p=0.039). The interaction of group (SMI/no SMI) and ApoE genotype was significant for episodic memory (p=0.005) and right and left hippocampal volumes (p=0.042; p=0.035). There were no within-group differences or interaction effects on speed and executive function composite measures or other volumetric measures.ConclusionsThe negative effect of ApoE4 on episodic memory and hippocampal volume in SMI supports SMI as a prodromal condition of AD. The positive effects of ApoE4 in subjects without SMI adds to a number of reports on positive ApoE4 effects in young and very old individuals.

Hippocampal volume and subjective memory impairment in depressed patients

2004 ◽  
Vol 19 (7) ◽  
pp. 438-440 ◽  
Author(s):  
Armin von Gunten ◽  
Maria A. Ron
Keyword(s):  
Memory Impairment ◽  
Hippocampal Volume ◽  
Subjective Memory ◽  
Subjective Memory Impairment ◽  
Depressed Patients ◽  
The Right ◽  
The Relationship

AbstractThe relationship between severity of subjective memory impairment and volume of the hippocampus/amygdala complex was investigated in non-demented depressed patients and it was found to correlate with decreasing volume in the right hippocampus.

P1-297: Associations between subjective memory impairment and hippocampal volume change in a prospective community-based MRI study

2008 ◽  
Vol 4 ◽  
pp. T306-T306
Author(s):  
Robert Stewart ◽  
Carole Dufouil ◽  
Ophelia Godin ◽  
Blandine Grassiot ◽  
Fabrice Crivello ◽  
...  
Keyword(s):  
Volume Change ◽  
Memory Impairment ◽  
Hippocampal Volume ◽  
Subjective Memory ◽  
Community Based ◽  
Subjective Memory Impairment ◽  
Mri Study

P4-206: Subjective memory impairment in healthy elderly specifically predicts decline in episodic memory over 8 years

2013 ◽  
Vol 9 ◽  
pp. P782-P782 ◽  
Author(s):  
Alexander Koppara ◽  
Steffi Riedel-Heller ◽  
Siegfried Weyerer ◽  
Horst Bickel ◽  
Michael Pentzek ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Memory Impairment ◽  
Subjective Memory ◽  
Subjective Memory Impairment ◽  
Healthy Elderly

P-129: Cognitive performance and grey matter structure in elderly with subjective memory impairment

2007 ◽  
Vol 3 (3S_Part_2) ◽  
pp. S140-S140
Author(s):  
Frank Jessen ◽  
Lukas Scheef ◽  
Karsten Schaper ◽  
Michael Wagner
Keyword(s):  
Cognitive Performance ◽  
Memory Impairment ◽  
Grey Matter ◽  
Subjective Memory ◽  
Subjective Memory Impairment

scholarly journals Longitudinal neuroimaging correlates of subjective memory impairment: 4-year prospective community study

2011 ◽  
Vol 198 (3) ◽  
pp. 199-205 ◽  
Author(s):  
Robert Stewart ◽  
Ophélia Godin ◽  
Fabrice Crivello ◽  
Pauline Maillard ◽  
Bernard Mazoyer ◽  
...  
Keyword(s):  
White Matter ◽  
Older People ◽  
Cognitive Decline ◽  
Volume Change ◽  
Memory Impairment ◽  
Hippocampal Volume ◽  
Subjective Memory ◽  
Subjective Memory Impairment ◽  
Brain Changes

BackgroundComplaints about memory are common in older people but their relationship with underlying brain changes is controversial.AimsTo investigate the relationship between subjective memory impairment and previous or subsequent changes in white matter lesions and brain volumes.MethodIn a community cohort study of 1336 people without dementia, 4-year changes in brain magnetic resonance imaging measures were investigated as correlates of subjective memory impairment at baseline and follow-up.ResultsSubjective memory impairment at baseline was associated with subsequent change in hippocampal volume and at follow-up impairment was associated with previous change in hippocampal, cerebrospinal fluid and grey matter volume and with subcortical white matter lesion increases. All associations with volume changes were U-shaped with significant quadratic terms – associations between least decline and subjective memory impairment were potentially explained by lower baseline hippocampal volumes in the groups with least volume change. Associations between hippocampal volume change and subjective memory impairment at follow-up were independent of cognitive decline and depressive symptoms, they were stronger in participants with the apolipoprotein E (APOE) ∊4 allele and in those without baseline subjective memory impairment.ConclusionsComplaints of poor memory by older people, particularly when new, may be a realistic subjective appraisal of recent brain changes independent of observed cognitive decline.

scholarly journals Cognitive Blackouts in Mild Cognitive Impairment and Alzheimer’s Dementia

2018 ◽  
Vol 8 (1) ◽  
pp. 72-76
Author(s):  
Georg Adler ◽  
Agnies Marczak ◽  
Jana Binder
Keyword(s):  
Cognitive Impairment ◽  
Depressive Symptoms ◽  
Mild Cognitive Impairment ◽  
Cognitive Performance ◽  
Memory Impairment ◽  
Early Recognition ◽  
Alzheimer’S Dementia ◽  
Subjective Memory ◽  
Alzheimer's Dementia ◽  
Subjective Memory Impairment

Background: Cognitive blackouts, e.g. moments of amnesia, disorientation, or perplexity may be an early sign of incipient Alzheimer’s dementia (AD). A short questionnaire, the checklist for cognitive blackouts (CCB), was evaluated cross-sectionally in users of a memory clinic. Methods: The CCB was performed in 130 subjects, who further underwent a neuropsychological and clinical examination. Subjective memory impairment and depressive symptoms were assessed. Differences in the CCB score between diagnostic groups and relationships with cognitive performance, depression, and subjective memory impairment were analyzed. Results: The CCB score was increased in mild cognitive impairment of the amnestic type or mild AD and correctly predicted 69.2% of the respective subjects. It was negatively correlated with cognitive performance, positively correlated with depressive symptoms, and substantially increased in subjects who estimated their memory poorer than that of other persons of their age. Discussion: The CCB may be a helpful screening tool for the early recognition of AD.

The Anterior-posterior Functional Connectivity Disconnection in the Elderly with Subjective Memory Impairment and Amnestic Mild Cognitive Impairment

2020 ◽  
Vol 17 (4) ◽  
pp. 373-381
Author(s):  
Wuhai Tao ◽  
Jinping Sun ◽  
Xin Li ◽  
Wen Shao ◽  
Jing Pei ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Memory Impairment ◽  
Amnestic Mild Cognitive Impairment ◽  
Magnetic Resonance Imaging Scan ◽  
Subjective Memory ◽  
Long Distance ◽  
Whole Brain ◽  
Subjective Memory Impairment

Background: Subjective Memory Impairment (SMI) may tremendously increase the risk of Alzheimer’s Disease (AD). The full understanding of the neuromechanism of SMI will shed light on the early intervention of AD. Methods: In the current study, 23 Healthy Controls (HC), 22 SMI subjects and 24 amnestic Mild Cognitive Impairment (aMCI) subjects underwent the comprehensive neuropsychological assessment and the resting-state functional magnetic resonance imaging scan. The difference in the connectivity of the Default Mode Network (DMN) and Functional Connectivity (FC) from the Region of Interest (ROI) to the whole brain were compared, respectively. Results: The results showed that HC and SMI subjects had significantly higher connectivity in the region of the precuneus area compared to aMCI subjects. However, from this region to the whole brain, SMI and aMCI subjects had significant FC decrease in the right anterior cingulum, left superior frontal and left medial superior frontal gyrus compared to HC. In addition, this FC change was significantly correlated with the cognitive function decline in participants. Conclusion: Our study indicated that SMI subjects had relatively intact DMN connectivity but impaired FC between the anterior and posterior brain. The findings suggest that long-distance FC is more vulnerable than the short ones in the people with SMI.

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