scholarly journals Longitudinal neuroimaging correlates of subjective memory impairment: 4-year prospective community study

2011 ◽  
Vol 198 (3) ◽  
pp. 199-205 ◽  
Author(s):  
Robert Stewart ◽  
Ophélia Godin ◽  
Fabrice Crivello ◽  
Pauline Maillard ◽  
Bernard Mazoyer ◽  
...  
Keyword(s):  
White Matter ◽  
Older People ◽  
Cognitive Decline ◽  
Volume Change ◽  
Memory Impairment ◽  
Hippocampal Volume ◽  
Subjective Memory ◽  
Subjective Memory Impairment ◽  
Brain Changes

BackgroundComplaints about memory are common in older people but their relationship with underlying brain changes is controversial.AimsTo investigate the relationship between subjective memory impairment and previous or subsequent changes in white matter lesions and brain volumes.MethodIn a community cohort study of 1336 people without dementia, 4-year changes in brain magnetic resonance imaging measures were investigated as correlates of subjective memory impairment at baseline and follow-up.ResultsSubjective memory impairment at baseline was associated with subsequent change in hippocampal volume and at follow-up impairment was associated with previous change in hippocampal, cerebrospinal fluid and grey matter volume and with subcortical white matter lesion increases. All associations with volume changes were U-shaped with significant quadratic terms – associations between least decline and subjective memory impairment were potentially explained by lower baseline hippocampal volumes in the groups with least volume change. Associations between hippocampal volume change and subjective memory impairment at follow-up were independent of cognitive decline and depressive symptoms, they were stronger in participants with the apolipoprotein E (APOE) ∊4 allele and in those without baseline subjective memory impairment.ConclusionsComplaints of poor memory by older people, particularly when new, may be a realistic subjective appraisal of recent brain changes independent of observed cognitive decline.

P1-297: Associations between subjective memory impairment and hippocampal volume change in a prospective community-based MRI study

2008 ◽  
Vol 4 ◽  
pp. T306-T306
Author(s):  
Robert Stewart ◽  
Carole Dufouil ◽  
Ophelia Godin ◽  
Blandine Grassiot ◽  
Fabrice Crivello ◽  
...  
Keyword(s):  
Volume Change ◽  
Memory Impairment ◽  
Hippocampal Volume ◽  
Subjective Memory ◽  
Community Based ◽  
Subjective Memory Impairment ◽  
Mri Study

SCREENING FOR DEMENTIA: IS 1 SIMPLE QUESTION THE ANSWER?

2015 ◽  
Vol 86 (11) ◽  
pp. e4.152-e4
Author(s):  
Baba Aji ◽  
Andrew Larner
Keyword(s):  
Memory Impairment ◽  
Seizure Type ◽  
Subjective Memory ◽  
Subjective Memory Impairment ◽  
The Past ◽  
Dementia Screening ◽  
Memory Problems ◽  
Simple Question ◽  
Screening Question

ObjectiveTo examine the diagnostic utility of the dementia screening question from the DoH Dementia CQUIN document (2012) in consecutive patients in a dedicated epilepsy clinic, individuals in whom memory complaints are common.Results100 consecutive outpatients (M:F=61:39, median age 44.5 years) were asked ‘Have you been more forgetful in the past 12 months to the extent that it has significantly affected your life?’, as advocated in the Dementia CQUIN document. There was a 48% yes response. No patient was adjudged to have dementia. Comparing the yes/no groups, there was no difference in sex ratio, age, seizure type, or use of antiepileptic drugs (monotherapy versus polytherapy). Those answering yes were more likely to be follow-up than new patients. Intergroup difference in epilepsy duration showed a trend to longer duration in the yes group. The most common examples of memory problems volunteered were forgetting to attend appointments, take medications, or switch off appliances, suggestive of attentional rather than mnestic problems.ConclusionsThese data suggest that the Dementia CQUIN screening question has very low specificity, and hence will identify many false positives, with risk of overdiagnosis of dementia in individuals with purely subjective memory impairment.

Hippocampal volume and subjective memory impairment in depressed patients

2004 ◽  
Vol 19 (7) ◽  
pp. 438-440 ◽  
Author(s):  
Armin von Gunten ◽  
Maria A. Ron
Keyword(s):  
Memory Impairment ◽  
Hippocampal Volume ◽  
Subjective Memory ◽  
Subjective Memory Impairment ◽  
Depressed Patients ◽  
The Right ◽  
The Relationship

AbstractThe relationship between severity of subjective memory impairment and volume of the hippocampus/amygdala complex was investigated in non-demented depressed patients and it was found to correlate with decreasing volume in the right hippocampus.

scholarly journals TRAJECTORIES OF SUBJECTIVE MEMORY IMPAIRMENT AND OBJECTIVE COGNITIVE DECLINE IN U.S. OLDER ADULTS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S205-S205
Author(s):  
Hanzhang Xu ◽  
Matthew E Dupre ◽  
Bei Wu
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Memory Impairment ◽  
Subjective Memory ◽  
Subjective Memory Impairment ◽  
Logistic Regressions ◽  
Dual Trajectories ◽  
Nationally Representative ◽  
Low Educated ◽  
Retirement Study

Abstract We examined the dual trajectories of subjective memory impairment (SMI) and objective cognitive decline and their associated factors in U.S. older adults. We used data from the Health and Retirement Study which includes a nationally representative sample of 19,408 Americans age 65 and older from 1998 to 2016. Trajectories of SMI and objective cognitive decline were simultaneously characterized using a group-based trajectory model and multinomial logistic regressions were used to assess factors associated with the dual-trajectory typologies. Four dual-trajectories were identified: “minimal SMI and stable-low cognitive decline” (33.1% of respondents); “minimal SMI with accelerated cognitive decline” (28.2%); “significant SMI with moderate cognitive decline” (21.0%); and “moderate SMI with steady cognitive decline” (17.6%). Being male, minority, low educated, living alone, and having comorbidities were associated with trajectories featuring greater SMI or more rapid deterioration in cognition. The results suggest complex co-occurring changes in subjective memory and objective cognition in older adults.

scholarly journals The association between vascular factors and subjective memory impairment in older people: The HUNT Study, Norway

2012 ◽  
Vol 22 (2) ◽  
Author(s):  
Ellen Melbye Langballe ◽  
Kristian Tambs ◽  
Ingvild Saltvedt ◽  
Kristian Midthjell ◽  
Jostein Holmen
Keyword(s):  
Blood Pressure ◽  
Heart Disease ◽  
Alcohol Consumption ◽  
Older People ◽  
Exercise Intensity ◽  
Memory Impairment ◽  
Subjective Memory ◽  
High Systolic Blood Pressure ◽  
Subjective Memory Impairment ◽  
High Exercise Intensity

<p><em><strong>Objectives:</strong></em> Subjective memory impairment (SMI) is often considered an early sign of dementia. This study investigates the relationship between SMI and dementia-related vascular factors in older people.</p><p><em><strong>Method:</strong></em> This study was based on data from 12,255 individuals, 65 years and older, participating in the Nord-Trøndelag health study, third survey 2006-08 (HUNT3). SMI, vascular diseases, exercise, smoking, and alcohol consumption were self-reported. Blood pressure, cholesterol and body mass index (BMI) were clinically measured. SMI were predicted using linear regression analysis.</p><p><em><strong>Results:</strong></em> Stroke and heart disease were associated with SMI. High exercise intensity was associated with less SMI. Respondents with high systolic blood pressure (SBP) reported less SMI than those with moderate SBP. In men, low SBP was associated with significantly more SMI compared to those with moderate SBP. In women, moderate alcohol consumption compared to low alcohol consumption was associated with significantly more SMI.</p><p><em><strong>Conclusion:</strong></em> SMI was positively associated with stroke and heart disease in this study. For the other investigated vascular factors, we did not find strong relationships with SMI. However, for preventive and treatment purposes, it is noteworthy that high exercise intensity and high systolic blood pressure was associated with less SMI in both genders.</p>

Disrupted White Matter Networks from Subjective Memory Impairment to Amnestic Mild Cognitive Impairment

2021 ◽  
Vol 18 (1) ◽  
pp. 35-44
Author(s):  
Wen Shao ◽  
Xuwen He ◽  
Xin Li ◽  
Wuhai Tao ◽  
Junying Zhang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
White Matter ◽  
Memory Impairment ◽  
Diffusion Tensor ◽  
Amnestic Mild Cognitive Impairment ◽  
Subjective Memory ◽  
Subjective Memory Impairment ◽  
Parietal Lobes ◽  
Network Disruptions

Background and Objective: Subjective memory impairment (SMI) is a preclinical stage prior to amnestic mild cognitive impairment (aMCI) along with the Alzheimer’s disease (AD) continuum. We hypothesized that SMI patients had white matter (WM) network disruptions similar to those in aMCI patients. Methods: We used diffusion-tensor magnetic resonance imaging and graph theory to construct, analyze, and compare the WM networks among 20 normal controls (NC), 20 SMI patients, and 20 aMCI patients. Results: Compared with the NC group, the SMI group had significantly decreased global and local efficiency and an increased shortest path length. Moreover, similar to the aMCI group, the SMI group had lower nodal efficiency in regions located in the frontal and parietal lobes, limbic systems, and caudate nucleus compared to that of the NC group. Conclusion: Similar to aMCI patient, SMI patients exhibited WM network disruptions, and detection of these disruptions could facilitate the early detection of SMI.

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