scholarly journals Heritability of tic disorders: a twin-family study

2016 ◽  
Vol 47 (6) ◽  
pp. 1085-1096 ◽  
Author(s):  
N. R. Zilhão ◽  
M. C. Olthof ◽  
D. J. A. Smit ◽  
D. C. Cath ◽  
L. Ligthart ◽  
...  
Keyword(s):  
Structural Equation ◽  
Large Population ◽  
Epidemiological Studies ◽  
Population Based ◽  
Tic Disorders ◽  
Equation Modeling ◽  
Shared Environment ◽  
Tic Disorder ◽  
Heritability Estimates ◽  
Additive Genetic Effects

BackgroundGenetic–epidemiological studies that estimate the contributions of genetic factors to variation in tic symptoms are scarce. We estimated the extent to which genetic and environmental influences contribute to tics, employing various phenotypic definitions ranging between mild and severe symptomatology, in a large population-based adult twin-family sample.MethodIn an extended twin-family design, we analysed lifetime tic data reported by adult mono- and dizygotic twins (n = 8323) and their family members (n = 7164; parents and siblings) from 7311 families in the Netherlands Twin Register. We measured tics by the abbreviated version of the Schedule for Tourette and Other Behavioral Syndromes. Heritability was estimated by genetic structural equation modeling for four tic disorder definitions: three dichotomous and one trichotomous phenotype, characterized by increasingly strictly defined criteria.ResultsPrevalence rates of the different tic disorders in our sample varied between 0.3 and 4.5% depending on tic disorder definition. Tic frequencies decreased with increasing age. Heritability estimates varied between 0.25 and 0.37, depending on phenotypic definitions. None of the phenotypes showed evidence of assortative mating, effects of shared environment or non-additive genetic effects.ConclusionsHeritabilities of mild and severe tic phenotypes were estimated to be moderate. Overlapping confidence intervals of the heritability estimates suggest overlapping genetic liabilities between the various tic phenotypes. The most lenient phenotype (defined only by tic characteristics, excluding criteria B, C and D of DSM-IV) rendered sufficiently reliable heritability estimates. These findings have implications in phenotypic definitions for future genetic studies.

scholarly journals Heritability of language laterality assessed by functional transcranial Doppler ultrasound: a twin study

2020 ◽  
Vol 4 ◽  
pp. 161
Author(s):  
Dorothy V.M. Bishop ◽  
Timothy C. Bates
Keyword(s):  
Doppler Ultrasound ◽  
Transcranial Doppler ◽  
Structural Equation ◽  
Transcranial Doppler Ultrasound ◽  
Equation Modeling ◽  
Shared Environment ◽  
Functional Language ◽  
Laterality Index ◽  
Heritability Estimates ◽  
Language Laterality

Background: Prior studies have estimated heritability of around 0.25 for the trait of handedness, with studies of structural brain asymmetry giving estimates in a similar or lower range. Little is known about heritability of functional language lateralization. This report describes heritability estimates using functional language laterality and handedness phenotypes in a twin sample previously reported by Wilson and Bishop (2018). Methods: The total sample consisted of 194 twin pairs (49% monozygotic) aged from 6 to 11 years. A language laterality index was obtained for 141 twin pairs, who completed a protocol where relative blood flow through left and right middle cerebral arteries was measured using functional transcranial Doppler ultrasound (fTCD) while the child described animation sequences. Handedness data was available from the Edinburgh Handedness Inventory (EHI) and Quantification of Hand Preference (QHP) for all 194 pairs. Heritability was assessed using conventional structural equation modeling, assuming no effect of shared environment (AE model). Results: For the two handedness measures, heritability estimates were consistent with prior research: 0.23 and 0.22 respectively for the EHI and QHP. For the language laterality index, however, the twin-cotwin correlations were close to zero for both MZ and DZ twins, and the heritability estimate was zero. Conclusions: A single study cannot rule out a genetic effect on language lateralisation. It is possible that the low twin-cotwin correlations were affected by noisy data: although the split-half reliability of the fTCD-based laterality index was high (0.85), we did not have information on test-retest reliability in children, which is likely to be lower. We cannot reject the hypothesis that there is low but nonzero heritability for this trait, but our data suggest that individual variation in language lateralisation is predominantly due to stochastic variation in neurodevelopment.

scholarly journals Heritability of language laterality assessed by functional transcranial Doppler ultrasound: a twin study

2020 ◽  
Vol 4 ◽  
pp. 161
Author(s):  
Dorothy V.M. Bishop ◽  
Timothy C. Bates
Keyword(s):  
Doppler Ultrasound ◽  
Transcranial Doppler ◽  
Structural Equation ◽  
Transcranial Doppler Ultrasound ◽  
Equation Modeling ◽  
Shared Environment ◽  
Functional Language ◽  
Laterality Index ◽  
Heritability Estimates ◽  
Language Laterality

Background: Prior studies have estimated heritability of around 0.25 for the trait of handedness, with studies of structural brain asymmetry giving estimates in a similar or lower range. Little is known about heritability of functional language lateralization. This report describes heritability estimates using functional language laterality and handedness phenotypes in a twin sample previously reported by Wilson and Bishop (2018). Methods: The total sample consisted of 194 twin pairs (49% monozygotic) aged from 6 to 11 years. A language laterality index was obtained for 141 twin pairs, who completed a protocol where relative blood flow through left and right middle cerebral arteries was measured using functional transcranial Doppler ultrasound (fTCD) while the child described animation sequences. Handedness data was available from the Edinburgh Handedness Inventory (EHI) and Quantification of Hand Preference (QHP) for all 194 pairs. Heritability was assessed using conventional structural equation modeling, assuming no effect of shared environment (AE model). Results: For the two handedness measures, heritability estimates (95% CI) were consistent with prior research: .25 (.03 - .34) and .18 (0 – .31) respectively for the EHI and QHP. For the language laterality index, however, the twin-cotwin correlations were close to zero for both MZ and DZ twins, and the heritability estimate was zero (0 - .15). Conclusions: A single study cannot rule out a genetic effect on language lateralisation. It is possible that the low twin-cotwin correlations were affected by noisy data: although the split-half reliability of the fTCD-based laterality index was high (0.85), we did not have information on test-retest reliability in children, which is likely to be lower. We cannot reject the hypothesis that there is low but nonzero heritability for this trait, but our data suggest that individual variation in language lateralisation is predominantly due to stochastic variation in neurodevelopment.

scholarly journals A Life Course Study of Genetic and Environmental Influences on Work Incapacity

2019 ◽  
Vol 23 (1) ◽  
pp. 16-22
Author(s):  
Karoline B. Seglem ◽  
Fartein A. Torvik ◽  
Espen Røysamb ◽  
Line C. Gjerde ◽  
Per Magnus ◽  
...  
Keyword(s):  
Structural Equation ◽  
Large Population ◽  
Environmental Influences ◽  
Population Based ◽  
National Registry ◽  
Equation Modeling ◽  
Aging Workforce ◽  
Total Proportion ◽  
Genetic And Environmental Factors ◽  
High Degree

AbstractWork incapacity is a major public health challenge and an economic burden to both society and individuals. Understanding the underlying causes is becoming ever more relevant as many countries face an aging workforce. We examined stability and change in genetic and environmental factors influencing work incapacity from age 18 until retirement, and sex differences in these effects. The large population-based sample comprised information from 28,759 twins followed for up to 23 years combined with high-quality national registry data. We measured work incapacity as the total proportion of potential workdays lost due to sickness absence, rehabilitation and disability benefits. Structural equation modeling with twin data indicated moderate genetic influences on work incapacity throughout life in both men and women, with a high degree of genetic stability from young to old adulthood. Environmental influences were mainly age-specific. Our results indicate that largely the same genetic factors influence individual differences in work incapacity throughout young, middle and older adulthood, despite major differences in degree of work incapacity and probable underlying medical causes.

scholarly journals Genetic Contributions to Subtypes of Aggression

2005 ◽  
Vol 8 (5) ◽  
pp. 483-491 ◽  
Author(s):  
Lannie Ligthart ◽  
Meike Bartels ◽  
Rosa A. Hoekstra ◽  
James J. Hudziak ◽  
Dorret I. Boomsma
Keyword(s):  
Relational Aggression ◽  
Structural Equation ◽  
Child Behavior Checklist ◽  
Equation Modeling ◽  
Shared Environment ◽  
Nonshared Environment ◽  
Aggression Subtypes ◽  
Direct Aggression ◽  
Genetic Contributions ◽  
Additive Genetic Effects

AbstractBoys and girls may display different styles of aggression. The aim of this study was to identify subtypes of aggression within the Child Behavior Checklist (CBCL) aggression scale, and determine their characteristics for both sexes. Maternal CBCL ratings of 7449 7-year-old twin pairs were analyzed using principal components analyses to identify sub- types of aggression, and structural equation modeling to carry out genetic analyses. Two aggression subtypes were identified: relational and direct aggression. The correlation between these subtypes was .58 for boys and .47 for girls. Boys had higher mean scores for both subtypes of aggression, but sex differences were largest for direct aggression. For relational aggression, 66% of the variance was due to additive genetic influences, 16% to shared environment and 18% to nonshared environment. For direct aggression, additive genetic effects accounted for 53% of the variance in males and 60% in females, shared environment explained 23% of the variance in males and 13% in females, and nonshared environmental effects explained 24% of the variance in males and 27% in females. Covariance between the aggression subtypes was mostly accounted for by additive genetic (55% for boys, 58% for girls) and shared environmental influences (33% for boys, 30% for girls). Direct and relational aggression were both influenced by one underlying set of shared environmental factors, but only partly by the same genes (the genetic correlation was .54 for boys and .43 for girls). These findings may have implications for how aggressive behavior should be assessed in boys and girls.

Is disabling fatigue in childhood influenced by genes?

1999 ◽  
Vol 29 (2) ◽  
pp. 279-282 ◽  
Author(s):  
A. FARMER ◽  
J. SCOURFIELD ◽  
N. MARTIN ◽  
A. CARDNO ◽  
P. McGUFFIN
Keyword(s):  
Structural Equation ◽  
Chronic Fatigue ◽  
Population Based ◽  
Information Criteria ◽  
Shared Environment ◽  
Tetrachoric Correlation ◽  
Acceptable Model ◽  
Medically Unexplained ◽  
Akaike’S Information Criteria ◽  
Additive Genetic Effects

Background. Medically unexplained chronic fatigue in childhood may cause considerable disability and (by definition) its cause remains unclear. A study of fatigue in healthy twins has been undertaken to examine whether or not genetic factors play a part.Method. A questionnaire survey of the main carers of an epidemiological population-based sample of 670 twin pairs who were asked about periods of unexplained and disabling fatigue in their twins. Out of 1340 individuals a period of disabling fatigue was reported for 92 (6·9%). Thirty-three (2·5%) reported disabling fatigue for more than 1 month. Zygosity could be confidently assigned in 98% of the sample providing 278 monozygotic (MZ) and 378 dizygotic (DZ) pairs. These data were analysed using a structural equation modelling approach.Results. The results showed that disabling fatigue in childhood is highly familial with an MZ tetrachoric correlation (rMZ) of 0·81 and a DZ tetrachoric correlation (rDZ) of 0·59, for fatigue lasting at least a week. The most acceptable model using Akaike's information criteria, was one containing additive genetic effects (A) and shared environment (C) plus residual (or non-shared) environment (E). For fatigue lasting at least a month rMZ was 0·75 and rDZ 0·47. The most acceptable model included just A and E. However, the role of shared environment could not be conclusively rejected.Conclusions. Unexplained disabling fatigue in childhood is substantially familial. Both genetic and shared environmental factors are worth further exploration in a search for the causes.

Adolescent religiousness and its influence on substance use: preliminary findings from the Mid-Atlantic School Age Twin Study

Twin Research ◽  
1999 ◽  
Vol 2 (2) ◽  
pp. 156-168 ◽  
Author(s):  
Brian M D'Onofrio ◽  
Lenn Murrelle ◽  
Lindon J Eaves ◽  
Michael E McCullough ◽  
Jessica L Landis ◽  
...  
Keyword(s):  
Substance Use ◽  
Drug Use ◽  
Problem Behavior ◽  
Twin Study ◽  
Structural Equation ◽  
Population Based ◽  
Spiritual Practices ◽  
Equation Modeling ◽  
School Age ◽  
Attitudes And Practices

AbstractResearch has consistently shown that religiousness is associated with lower levels of alcohol and drug use, but little is known about the nature of adolescent religiousness or the mechanisms through which it influences problem behavior in this age group. This paper presents preliminary results from the Mid-Atlantic School Age Twin Study, a prospective, population-based study of 6–18-year-old twins and their mothers. Factor analysis of a scale developed to characterize adolescent religiousness, the Religious Attitudes and Practices Inventory (RAPI), revealed three factors: theism, religious/spiritual practices, and peer religiousness. Twin correlations and univariate behavior-genetic models for these factors and a measure of belief that drug use is sinful reveal in 357 twin pairs that common environmental factors significantly influence these traits, but a minor influence of genetic factors could not be discounted. Correlations between the multiple factors of adolescent religiousness and substance use, comorbid problem behavior, mood disorders, and selected risk factors for substance involvement are also presented. Structural equation modeling illustrates that specific religious beliefs about the sinfulness of drugs and level of peer religiousness mediate the relationship between theistic beliefs and religious/spiritual practices on substance use. Limitations and future analyses are discussed.

scholarly journals Netherlands Twin Register: From Twins to Twin Families

2006 ◽  
Vol 9 (6) ◽  
pp. 849-857 ◽  
Author(s):  
Dorret I. Boomsma ◽  
Eco J. C. de Geus ◽  
Jacqueline M. Vink ◽  
Janine H. Stubbe ◽  
Marijn A. Distel ◽  
...  
Keyword(s):  
Large Population ◽  
Epidemiological Studies ◽  
Population Based ◽  
Adolescent And Young Adult ◽  
City Councils ◽  
Blood And Urine Samples ◽  
Twin Families ◽  
New Research ◽  
Adult Twins ◽  
National Databases

AbstractIn the late 1980s The Netherlands Twin Register (NTR) was established by recruiting young twins and multiples at birth and by approaching adolescent and young adult twins through city councils. The Adult NTR (ANTR) includes twins, their parents, siblings, spouses and their adult offspring. The number of participants in the ANTR who take part in survey and / or laboratory studies is over 22,000 subjects. A special group of participants consists of sisters who are mothers of twins. In the Young NTR (YNTR), data on more than 50,000 young twins have been collected. Currently we are extending the YNTR by including siblings of twins. Participants in YNTR and ANTR have been phenotyped every 2 to 3 years in longitudinal survey studies, since 1986 and 1991 for the YNTR and ANTR, respectively. The resulting large population-based datasets are used for genetic epidemiological studies and also, for example, to advance phenotyping through the development of new syndrome scales based on existing items from other inventories. New research developments further include brain imaging studies in selected and unselected groups, clinical assessment of psychopathology through interviews, and cross-referencing the NTR database to other national databases. A large biobank enterprise is ongoing in the ANTR in which blood and urine samples are collected for genotyping, expression analysis, and meta-bolomics studies. In this paper we give an update on the YNTR and ANTR phenotyping and on the ongoing ANTR biobank studies.

Attributional Style as a Predictor of Hopelessness Depression

2006 ◽  
Vol 20 (4) ◽  
pp. 447-458 ◽  
Author(s):  
Edward D. Sturman ◽  
Myriam Mongrain ◽  
Paul M. Kohn
Keyword(s):  
Attributional Style ◽  
Latent Variable ◽  
Structural Equation ◽  
Depression Scale ◽  
Epidemiological Studies ◽  
Psychomotor Retardation ◽  
Equation Modeling ◽  
Depression Symptoms ◽  
Negative Events ◽  
Hopelessness Depression

Stable and global attributions for negative events were tested as predictors of hopelessness depression symptoms, obtained from a diagnostic interview for a past depressive episode in a sample of 102 graduate students. All participants were administered the Structured Clinical Interview for DSM–IV, Center for Epidemiological Studies Depression Scale, Personal Style Inventory, and a modified version of the Extended Attributional Style Questionnaire. A stable and global attributional style for negative events was significantly associated with a composite of hopelessness depression symptoms. A regression analysis revealed that attributional style significantly postdicted hopelessness depression symptoms when controlling for both sociotropy and autonomy. Structural equation modeling supported a model in which stable and global attributions predicted a latent variable, which we refer to as a motivational deficit, involving psychomotor retardation and fatigue as indicators. Therefore, this study obtained some support for the hopelessness model and highlights the vulnerability posed by attributional style ( Abramson, Metalsky, & Alloy, 1989 ).

Efektifitas Sistem Informasi Manajemen Bagi Pengguna Internal (Studi Kasus Pada PT Bank Lampung)

2018 ◽  
Vol 2 (2) ◽  
Author(s):  
Alhibarsyah Alhibarsyah ◽  
Keyword(s):  
Information Technology ◽  
Structural Equation ◽  
Information Needs ◽  
Information Quality ◽  
Service Providers ◽  
Statistical Technique ◽  
Population Based ◽  
Equation Modeling ◽  
Observation Data ◽  
Technology System

Abstract To fulfill information needs that are relevant, fast, and accurate, the application of information technology, especially computer-based is inseparable from the role of the three basic components of a computer. The success model of the information technology system developed by DeLone & McLean quickly received a response. PT. Bank Lampung as one of the banking service providers in Lampung, is the object of research to determine how variables affect the level of Quality System, Information Quality, Service Quality, Use and Satisfaction and Use of Benefits, to determine the level of effectiveness in PT Bank Lampung's internal customer management information system. SEM (Structural Equation Modeling) is a multivariate statistical technique that is a combination of factor analysis and regression analysis (correlation), which aims to examine the relationship between variables in the model. To explain the overall relationship that exists between the variables in this study using AMOS software (Moment Structure Analysis). This shows that the sample variance-covariance matrix (observation data) I s the same as the estimated matrix of variance-covariance (population) based on the model built, it is expected that the results of this study KI significantly influence P, KI significantly affects KP, KS influences significant impact on P, significantly affecting KS KP, KL significantly affected P, KL significantly affected KP, P significantly affected KP, P significantly affected M, KP significantly affected M.

Distribution and Heritability of Recurrent Ear Infections

1997 ◽  
Vol 106 (8) ◽  
pp. 624-632 ◽  
Author(s):  
Kari J. Kvaerner ◽  
Jennifer R. Harris ◽  
Kristian Tambs ◽  
Per Magnus
Keyword(s):  
Structural Equation ◽  
Genetic Factors ◽  
Age Of Onset ◽  
Population Based ◽  
Equation Modeling ◽  
Relative Contribution ◽  
Genes And Environment ◽  
Ear Infections ◽  
The Mean ◽  
Familial Environment

The distribution of recurrent ear infections was obtained from a population-based sample of 2,750 pairs of Norwegian twins born between 1967 and 1974. The lifetime prevalence of self-reported recurrent ear infections was 8.9%, with a significant predominance of female cases. The mean age of onset was 4.2 years, with a gradual decrease in occurrence from 2 to 7 years of age. Among monozygotic pairs, the rate of tetrachoric correlation between co-twins was almost identical in males (0.73, SE 0.08) and females (0.74, SE 0.06), but among the dizygotic pairs the correlation was clearly higher in males (0.53, SE 0.12) than in females (0.20, SE 0.12). The value in the unlike-sexed dizygotic twins (0.25, SE 0.05) was intermediate to that of the like-sexed male and female dizygotic pairs. The relative contribution of genes and environment to variability in the predisposition to develop otitis media was estimated by means of structural equation modeling. Variation in liability to ear infections was mainly explained by additive genetic and dominance factors in females, for whom heritability was estimated at 74%. The remaining 26% of the variation in liability was explained by individual environmental factors. In males, 45% of the variation could be accounted for by genetic factors, 29% by common familial environment, and the remaining 26% by individual environmental effects.

Sign in / Sign up

Export Citation Format

Share Document