scholarly journals Accuracy of diagnostic classification algorithms using cognitive-, electrophysiological-, and neuroanatomical data in antipsychotic-naïve schizophrenia patients

2018 ◽  
Vol 49 (16) ◽  
pp. 2754-2763 ◽  
Author(s):  
Bjørn H. Ebdrup ◽  
Martin C. Axelsen ◽  
Nikolaj Bak ◽  
Birgitte Fagerlund ◽  
Bob Oranje ◽  
...  

AbstractBackgroundA wealth of clinical studies have identified objective biomarkers, which separate schizophrenia patients from healthy controls on a group level, but current diagnostic systems solely include clinical symptoms. In this study, we investigate if machine learning algorithms on multimodal data can serve as a framework for clinical translation.MethodsForty-six antipsychotic-naïve, first-episode schizophrenia patients and 58 controls underwent neurocognitive tests, electrophysiology, and magnetic resonance imaging (MRI). Patients underwent clinical assessments before and after 6 weeks of antipsychotic monotherapy with amisulpride. Nine configurations of different supervised machine learning algorithms were applied to first estimate the unimodal diagnostic accuracy, and next to estimate the multimodal diagnostic accuracy. Finally, we explored the predictability of symptom remission.ResultsCognitive data significantly classified patients from controls (accuracies = 60–69%;pvalues = 0.0001–0.009). Accuracies of electrophysiology, structural MRI, and diffusion tensor imaging did not exceed chance level. Multimodal analyses with cognition plus any combination of one or more of the remaining three modalities did not outperform cognition alone. None of the modalities predicted symptom remission.ConclusionsIn this multivariate and multimodal study in antipsychotic-naïve patients, only cognition significantly discriminated patients from controls, and no modality appeared to predict short-term symptom remission. Overall, these findings add to the increasing call for cognition to be included in the definition of schizophrenia. To bring about the full potential of machine learning algorithms in first-episode, antipsychotic-naïve schizophrenia patients, carefula priorivariable selection based on independent data as well as inclusion of other modalities may be required.

2021 ◽  
Vol 1916 (1) ◽  
pp. 012042
Author(s):  
Ranjani Dhanapal ◽  
A AjanRaj ◽  
S Balavinayagapragathish ◽  
J Balaji

2021 ◽  
Vol 11 (15) ◽  
pp. 6728
Author(s):  
Muhammad Asfand Hafeez ◽  
Muhammad Rashid ◽  
Hassan Tariq ◽  
Zain Ul Abideen ◽  
Saud S. Alotaibi ◽  
...  

Classification and regression are the major applications of machine learning algorithms which are widely used to solve problems in numerous domains of engineering and computer science. Different classifiers based on the optimization of the decision tree have been proposed, however, it is still evolving over time. This paper presents a novel and robust classifier based on a decision tree and tabu search algorithms, respectively. In the aim of improving performance, our proposed algorithm constructs multiple decision trees while employing a tabu search algorithm to consistently monitor the leaf and decision nodes in the corresponding decision trees. Additionally, the used tabu search algorithm is responsible to balance the entropy of the corresponding decision trees. For training the model, we used the clinical data of COVID-19 patients to predict whether a patient is suffering. The experimental results were obtained using our proposed classifier based on the built-in sci-kit learn library in Python. The extensive analysis for the performance comparison was presented using Big O and statistical analysis for conventional supervised machine learning algorithms. Moreover, the performance comparison to optimized state-of-the-art classifiers is also presented. The achieved accuracy of 98%, the required execution time of 55.6 ms and the area under receiver operating characteristic (AUROC) for proposed method of 0.95 reveals that the proposed classifier algorithm is convenient for large datasets.


Author(s):  
Charalambos Kyriakou ◽  
Symeon E. Christodoulou ◽  
Loukas Dimitriou

The paper presents a data-driven framework and related field studies on the use of supervised machine learning and smartphone technology for the spatial condition-assessment mapping of roadway pavement surface anomalies. The study explores the use of data, collected by sensors from a smartphone and a vehicle’s onboard diagnostic device while the vehicle is in movement, for the detection of roadway anomalies. The research proposes a low-cost and automated method to obtain up-to-date information on roadway pavement surface anomalies with the use of smartphone technology, artificial neural networks, robust regression analysis, and supervised machine learning algorithms for multiclass problems. The technology for the suggested system is readily available and accurate and can be utilized in pavement monitoring systems and geographical information system applications. Further, the proposed methodology has been field-tested, exhibiting accuracy levels higher than 90%, and it is currently expanded to include larger datasets and a bigger number of common roadway pavement surface defect types. The proposed system is of practical importance since it provides continuous information on roadway pavement surface conditions, which can be valuable for pavement engineers and public safety.


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