Organic Affective Psychosis Associated with the Routine Use of Non-prescription Cold Preparations

1990 ◽  
Vol 156 (4) ◽  
pp. 572-575 ◽  
Author(s):  
Terry M. Brown ◽  
Robert N. Golden ◽  
Dwight L. Evans
Keyword(s):  
Affective Disorder ◽  
Affective Disorders ◽  
Short Term ◽  
Drug Induced ◽  
Affective Psychosis ◽  
Clinical Reaction ◽  
Balance Hypothesis

A patient experienced an organic affective psychosis on three separate occasions after taking recommended doses of non-prescription cold/sinus preparations. The possible underlying pharmacological mechanisms of this clinical reaction lend support to the cholinergic-adrenergic balance hypothesis of affective disorders. Recognition of this acute drug-induced state can lead to appropriate short-term pharmacotherapy and can prevent misdiagnosis of a major affective disorder or schizophrenia.

Ageing and Affective Disorders: The Age at First Onset of Affective Disorders in Scotland, 1969–1978

1985 ◽  
Vol 147 (2) ◽  
pp. 180-187 ◽  
Author(s):  
John M. Eagles ◽  
Lawrence J. Whalley
Keyword(s):  
Affective Disorder ◽  
Affective Disorders ◽  
Steady Increase ◽  
Social Psychological ◽  
Affective Psychosis ◽  
Affective Psychoses ◽  
Admission Rates ◽  
Clear Cut ◽  
Psychiatric Units ◽  
First Onset

SummaryFirst admission rates from 1969–78 for Scottish psychiatric units were calculated for discharge diagnoses of affective psychosis for each five-year age-group from 15 years to over 74 years. There were clear-cut linear increases in rates of depressive psychoses, mania, and all affective psychoses, consistent with a relatively steady increase in the rate of first-onset affective psychoses with increasing age. These findings are discussed in terms of social, psychological, and biological hypotheses of the causes of affective disorder. It is argued that no single factor could produce the observed linear increases with age and that the data appear more consistent with an integrative aetiological model of affective disorder.

Acetaminophen: Macula densa hypersecretory activity by induced hepatotoxicity

1987 ◽  
Vol 45 ◽  
pp. 934-935
Author(s):  
S.S. Poolsawat ◽  
C.A. Huerta ◽  
S.TY. Lae ◽  
G.A. Miranda
Keyword(s):  
Cell Proliferation ◽  
Liver Function ◽  
Chronic Inflammation ◽  
Foam Cell ◽  
Term Effect ◽  
Short Term ◽  
Drug Induced ◽  
Experimental Induction ◽  
Tissue Alterations ◽  
Toxic Responses

Introduction. Experimental induction of altered histology by chemical toxins is of particular importance if its outcome resembles histopathological phenomena. Hepatotoxic drugs and chemicals are agents that can be converted by the liver into various metabolites which consequently evoke toxic responses. Very often, these drugs are intentionally administered to resolve an illness unrelated to liver function. Because of hepatic detoxification, the resulting metabolites are suggested to be integrated into the macromolecular processes of liver function and cause an array of cellular and tissue alterations, such as increased cytoplasmic lysis, centrilobular and localized necroses, chronic inflammation and “foam cell” proliferation of the hepatic sinusoids (1-4).Most experimentally drug-induced toxicity studies have concentrated primarily on the hepatic response, frequently overlooking other physiological phenomena which are directly related to liver function. Categorically, many studies have been short-term effect investigations which seldom have followed up the complications to other tissues and organs when the liver has failed to function normally.

Reduced influence of affective disorders on perioperative complication rates, length of hospital stay, and healthcare costs following spinal fusion for adolescent idiopathic scoliosis

2019 ◽  
Vol 24 (6) ◽  
pp. 722-727
Author(s):  
Aladine A. Elsamadicy ◽  
Andrew B. Koo ◽  
Megan Lee ◽  
Adam J. Kundishora ◽  
Christopher S. Hong ◽  
...  
Keyword(s):  
Quality Of Care ◽  
Idiopathic Scoliosis ◽  
Affective Disorder ◽  
Affective Disorders ◽  
Complication Rates ◽  
Total Cost ◽  
Adolescent Patients ◽  
Perioperative Complication ◽  
The Impact

OBJECTIVEIn the past decade, a gradual transition of health policy to value-based healthcare has brought increased attention to measuring the quality of care delivered. In spine surgery, adolescents with scoliosis are a population particularly at risk for depression, anxious feelings, and impaired quality of life related to back pain and cosmetic appearance of the deformity. With the rising prevalence of mental health ailments, it is necessary to evaluate the impact of concurrent affective disorders on patient care after spinal surgery in adolescents. The aim of this study was to investigate the impact that affective disorders have on perioperative complication rates, length of stay (LOS), and total costs in adolescents undergoing elective posterior spinal fusion (PSF) (≥ 4 levels) for idiopathic scoliosis.METHODSA retrospective study of the Kids’ Inpatient Database for the year 2012 was performed. Adolescent patients (age range 10–17 years old) with AIS undergoing elective PSF (≥ 4 levels) were selected using the International Classification of Diseases, Ninth Revision, Clinical Modification coding system. Patients were categorized into 2 groups at discharge: affective disorder or no affective disorder. Patient demographics, comorbidities, complications, LOS, discharge disposition, and total cost were assessed. The primary outcomes were perioperative complication rates, LOS, total cost, and discharge dispositions.RESULTSThere were 3759 adolescents included in this study, of whom 164 (4.4%) were identified with an affective disorder (no affective disorder: n = 3595). Adolescents with affective disorders were significantly older than adolescents with no affective disorders (affective disorder: 14.4 ± 1.9 years vs no affective disorder: 13.9 ± 1.8 years, p = 0.001), and had significantly different proportions of race (p = 0.005). Aside from hospital region (p = 0.016), no other patient- or hospital-level factors differed between the cohorts. Patient comorbidities did not differ significantly between cohorts. The number of vertebral levels involved was similar between the cohorts, with the majority of patients having 9 or more levels involved (affective disorder: 76.8% vs no affective disorder: 79.5%, p = 0.403). Postoperative complications were similar between the cohorts, with no significant difference in the proportion of patients experiencing a postoperative complication (p = 0.079) or number of complications (p = 0.124). The mean length of stay and mean total cost were similar between the cohorts. Moreover, the routine and nonroutine discharge dispositions were also similar between the cohorts, with the majority of patients having routine discharges (affective disorder: 93.9% vs no affective disorder: 94.9%, p = 0.591).CONCLUSIONSThis study suggests that affective disorders may not have a significant impact on surgical outcomes in adolescent patients undergoing surgery for scoliosis in comparison with adults. Further studies are necessary to elucidate how affective disorders affect adolescent patients with idiopathic scoliosis, which may improve provider approach in managing these patients perioperatively and at follow-up in hopes to better the overall patient satisfaction and quality of care delivered.

A High Prevalence of Affective Disorder Discovered in a ‘Schizophrenia Clinic’

1977 ◽  
Vol 22 (4) ◽  
pp. 181-183 ◽  
Author(s):  
Morton S. Rapp ◽  
Peggy Edwards
Keyword(s):  
Affective Disorder ◽  
Affective Disorders ◽  
Correct Diagnosis ◽  
Lithium Carbonate ◽  
Case Histories ◽  
Clinical Notes ◽  
The Past ◽  
High Prevalence ◽  
Incorrect Diagnosis

Fifty outpatients in a ‘schizophrenia clinic’ were examined, and sixteen were found to be suffering from periodic affective disorders. Nine of these were given lithium carbonate, and eight responded well. Case histories illustrate three separate reasons for incorrect diagnosis. Examination of extensive old clinical notes of five of these patients suggests that the problems of diagnosis which have been described in the literature in the past, continue to represent obstacles to correct diagnosis. Suggestions for improvement are offered.

Genetic Models of Affective Disorder: Application to Twin Data

1980 ◽  
Vol 29 (4) ◽  
pp. 289-294 ◽  
Author(s):  
Miron Baron
Keyword(s):  
Affective Disorder ◽  
Affective Disorders ◽  
Monozygotic Twins ◽  
Threshold Models ◽  
Twin Data ◽  
Bipolar Illness ◽  
Major Locus ◽  
Unipolar Disorder ◽  
Locus Model ◽  
Multiple Threshold

Twin data on bipolar and unipolar affective disorders are analyzed by multiple threshold models of inheritance. The two illness types are represented in the models on a continuum of genetic–environmental liability in which bipolar illness has a higher liability threshold than unipolar disorder. Autosomal single major locus model provides an acceptable fit to observed concordance rates in monozygotic twins. The multifactorial-polygenic model is rejected.

Some Reflections on the Nature of Affective Disorders, Arising from the Results of Prefrontal Leucotomy

1949 ◽  
Vol 95 (401) ◽  
pp. 795-825 ◽  
Author(s):  
Maurice Partridge
Keyword(s):  
Sixteenth Century ◽  
Affective Disorder ◽  
Affective Disorders

For the use of the term “affective disorder” there is good literary warrant. Shakespeare, writing in the last decade of the sixteenth century, or just before it, uses the word thus:“Necessity will make us all forswornThree thousand times within this three years' space;For every man with his affects is born,Not by might mastered, but by special grace” (92).

Genetic aetiology of mood disorders

2012 ◽  
pp. 650-658
Author(s):  
Pierre Oswald ◽  
Daniel Souery ◽  
Julien Mendlewicz
Keyword(s):  
Affective Disorder ◽  
Mood Disorders ◽  
Molecular Genetics ◽  
Psychosocial Factors ◽  
Affective Disorders ◽  
Social Life ◽  
Bipolar Affective Disorder ◽  
Molecular Genetic ◽  
The Social ◽  
Life Context

Advances towards the understanding of the etiological mechanisms involved in mood disorders provide interesting yet diverse hypotheses and promising models. In this context, molecular genetics has now been widely incorporated into genetic epidemiological research in psychiatry. Affective disorders and, in particular, bipolar affective disorder (BPAD) have been examined in many molecular genetic studies which have covered a large part of the genome, specific hypotheses such as mutations have also been studied. Most recent studies indicate that several chromosomal regions may be involved in the aetiology of BPAD. Other studies have reported the presence of anticipation in BPAD and in unipolar affective disorder (UPAD). In parallel to these new developments in molecular genetics, the classical genetic epidemiology, represented by twin, adoption and family studies, provided additional evidence in favour of the genetic hypothesis in mood disorders. Moreover, these methods have been improved through models to test the gene-environment interactions. In addition to genetic approaches, psychiatric research has focused on the role of psychosocial factors in the emergence of mood disorders. In this approach, psychosocial factors refer to the patient's social life context as well as to personality dimensions. Abnormalities in the social behavior such as impairment in social relationships have been observed during episode of affective disorders, and implicated in the etiology of affective disorders. Further, gender and socio-economic status also emerged as having a possible impact on the development of affective disorders. Finally, the onset and outcome of affective disorders could also be explained by interactions between the social life context and the individual's temperament and personality. The importance of temperament and personality characteristics in the etiology of depression has been emphasized in various theories, although disagreement exists with regard to terminology and the etiology. While significant advances have been done in these two major fields of research, it appears that integrative models, taking into account the interactions between biological (genetic) factors and social (psychosocial environment) variables offer the most reliable way to approach the complex mechanisms involved in the etiology and outcome of mood disorders. This chapter will review some of the most promising genetic and psychosocial hypotheses in mood disorders that can be integrated in interactive models.

Plasma Lithium Levels and Therapeutic Outcome in the Prophylaxis of Affective Disorders: A Retrospective Study

1982 ◽  
Vol 140 (6) ◽  
pp. 619-622 ◽  
Author(s):  
S. P. Sashidharan ◽  
R. J. McGuire ◽  
A. I. M. Glen
Keyword(s):  
Retrospective Study ◽  
Affective Disorder ◽  
Affective Disorders ◽  
Favourable Outcome ◽  
Therapeutic Outcome ◽  
Lithium Therapy ◽  
Affective Illness

SummaryPatients receiving prophylactic lithium therapy for primary affective disorder during a four year period were studied for recurrence of affective illness. Patients who had affective episodes during this period did not differ from those who remained well in age, sex or diagnosis. Those with a favourable outcome had spent significantly less time at serum lithium levels above 0.9 mmol/litre than those who had a recurrence of affective episodes.

Doctors' Holding Power in Practice: Section 5(2) of the Mental Health Act 1983

1995 ◽  
Vol 35 (3) ◽  
pp. 231-236 ◽  
Author(s):  
A D Hall ◽  
B K Puri ◽  
T Stewart ◽  
P S Grahame
Keyword(s):  
Mental Health ◽  
Psychotic Disorder ◽  
Psychiatric Service ◽  
Patient Admission ◽  
Case Note ◽  
Short Term ◽  
Affective Psychosis ◽  
Mental Health Act ◽  
Holding Power ◽  
Large Catchment

Section 5(2) of the Mental Health Act 1983 (England and Wales) is a commonly used short term power of detention often implemented by junior medical staff, which has no statutory right of appeal. There is little published analysis of its use in clinical practice. A detailed case note study of its use in a psychiatric service with a large catchment area is presented. Fifty-seven per cent of the patients detained under s.5(2) were female. Affective psychosis was over-represented in detained females, while schizophrenia and paranoid states were over-represented in males. Eight per cent of s.5(2) detentions were initiated via the nurses' holding power, s.5(4). None of these patients were subsequently regraded to s.2 or 3, which may be accounted for by the finding that personality disorder and alcohol dependence were more commonly diagnosed in this subgroup. Of s.5(2) detainees, none of those with a non-psychotic disorder were regraded to s.2 or 3. Three patients had not accepted in-patient admission prior to implementation of s.5(2). Moreover, 38 per cent of all s.5(2) detentions took place within 24 hours of admission. Patients with a psychotic disorder were more likely to be detained within 24 hours of admission. Doubts regarding the validity of consent to voluntary admission in these patients are raised.

Everyday creativity and bipolar and unipolar affective disorder: preliminary study of personal and family history

1992 ◽  
Vol 7 (2) ◽  
pp. 49-52 ◽  
Author(s):  
R Richards ◽  
DK Kinney ◽  
H Daniels ◽  
K Linkins
Keyword(s):  
Bipolar Disorder ◽  
Family History ◽  
Affective Disorder ◽  
Affective Disorders ◽  
Bipolar Disorders ◽  
Data Support ◽  
History Of ◽  
Preliminary Study ◽  
Everyday Creativity ◽  
Underlying Mechanisms

SummaryPreliminary new data support the enhancement of ‘everyday’ creativity among those persons with bipolar disorders who manifest milder rather than more severe mood elevations, and among certain individuals who are likely to carry bipolar liability but themselves show no clinical mood elevations – in this case, unipolar depressives with a family history of bipolar disorder, when compared with depressives lacking this history. Creativity was assessed using the lifetime creativity scales (Richards el al, 1988). Underlying mechanisms may be multifactorial and complex. Results suggest that both personal and family history should be considered when making predictions concerning creativity and affective disorders.

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