Depressed patients with schizophrenic or paranoid symptoms

1980 ◽  
Vol 10 (4) ◽  
pp. 665-675 ◽  
Author(s):  
I. F. Brockington ◽  
R. E. Kendell ◽  
S. Wainwright
Keyword(s):  
Family History ◽  
Affective Disorders ◽  
Final Diagnosis ◽  
Good Prognosis ◽  
Response To Treatment ◽  
Psychotic Symptoms ◽  
Affective Psychosis ◽  
Manic Depressive ◽  
Paranoid Symptoms ◽  
Definition Of

SYNOPSISFamily history, response to treatment and outcome are reported in a series of 76 patients presenting with both depression and schizophrenic or paranoid symptoms. About 10% of psychotic admissions to the Maudsley and Bethlem Royal Hospitals met a study definition of ‘schizodepressive’ illness. The patients were highly heterogeneous in history, clinical picture and outcome. Many followed a typical schizophrenic course, and others a typical course for affective disorders, but only 4 were given a final diagnosis of manic depressive disease. The best predictors of poor outcome were a mode of onset as an exacerbation of previous psychotic symptoms and the presence of schizophrenic symptoms at some time without depression. The best predictors of good outcome were Stephens' criteria of good prognosis schizophrenia and Kasanin's concept of ‘acute schizo-affective psychosis’. These findings are not easily reconciled with Kraepelin's two entities principle but suggest a continuum of outcome between schizophrenia and unipolar depressive psychosis.

Affective Disorder on Paternal and Maternal Sides

1973 ◽  
Vol 122 (566) ◽  
pp. 31-34 ◽  
Author(s):  
Julien Mendlewicz ◽  
Ronald R. Fieve ◽  
John D. Rainer ◽  
Mima Cataldo
Keyword(s):  
Family History ◽  
Major Gene ◽  
Positive Family History ◽  
Psychotic Symptoms ◽  
Polygenic Inheritance ◽  
Genetic Transmission ◽  
Bipolar Illness ◽  
First Degree Relatives ◽  
Manic Depressive

Recent family studies of manic-depressive psychosis have emphasized the role of genetics in the aetiology of this bipolar illness (3, 8). However, the mode of genetic transmission is still unknown, the main controversy being between major gene and polygenic inheritance. Furthermore, it is not yet evident whether bipolar illness constitutes a homogeneous entity or whether it may be subdivided into different genetic subgroups. Mendlewicz, Fieve, Rainer, and Fleiss (1) recently produced some evidence that bipolar psychosis can be differentiated into two subgroups on the basis of family history data. Two matched samples of 30 patients each were studied, distinguished by the presence or absence of bipolar illness in their first degree relatives. The patients with a positive family history (FH+) in first degree relatives showed earlier onset of illness and more psychotic symptoms occurring in the manic phase. Alcoholism, if present, was of an episodic pattern. In patients with a negative family history (FH—), there was a later onset of illness; psychotic symptoms occurred usually in the depressive phase; and alcoholism, when present, tended to be chronic.

Comments on the Northwick Park ‘Functional’ Psychosis Study

1989 ◽  
Vol 154 (3) ◽  
pp. 406-409 ◽  
Author(s):  
G. M. Goodwin ◽  
D. A. W. Johnson ◽  
R. G. McCreadie
Keyword(s):  
Depressive Symptoms ◽  
Depressed Mood ◽  
Mode Of Action ◽  
Response To Treatment ◽  
Psychotic Symptoms ◽  
Dopamine Antagonist ◽  
Mood Change ◽  
Manic Symptoms ◽  
Functional Psychosis ◽  
Manic Depressive

“Functional psychosis is conventionally subdivided into schizophrenia and manic depressive psychosis. Response to treatment is assumed to be a validating criterion for these diagnoses. The efficacy of pimozide (a dopamine antagonist neuroleptic), lithium, and a combination of the two was compared with that of placebo in a 4-week trial in 120 functionally psychotic patients, each of whom was assessed for psychotic symptoms, manic symptoms, and depressive symptoms. The sample was subdivided into patients with predominantly elevated mood, predominantly depressed mood, and no consistent mood change. Pimozide reduced psychotic symptoms in all groups of patients. The only significant effect of lithium was to reduce elevated mood. Thus dopamine blockade seems relevant to the resolution of psychotic symptoms in all types of ‘functional’ psychosis, but the mode of action of lithium in psychotic patients concerns only mood. Application of standardised classifications of functional psychosis to these data did not change this conclusion.”

Manic-Depressive Illness: A Comparative Study of Patients with and Without a Family History

1972 ◽  
Vol 120 (558) ◽  
pp. 523-530 ◽  
Author(s):  
J. Mendlewicz ◽  
R. R. Fieve ◽  
J. D. Rainer ◽  
J. L. Fleiss
Keyword(s):  
Family History ◽  
Comparative Study ◽  
Affective Disorders ◽  
Depressive Disorders ◽  
Clinical Observation ◽  
Depressive Illness ◽  
Manic Depressive Illness ◽  
Family Risk ◽  
Manic Depressive ◽  
Depressive Group

Early studies (21, 22, 25, 12) have pointed to a genetic component in the aetiology of manic-depressive disorders. More recently, careful clinical observation has suggested the division of the affective disorders into two distinct groups: the so-called bipolar or manic-depressive group and the unipolar type with recurrent depressions only (14, 27, 1). Although genetic differences in terms of family risk have been demonstrated between the so-called bipolar and unipolar psychoses, it is not yet evident whether each group constitutes a homogeneous entity. Moreover, the diagnosis of unipolar depressive disease for the authors cited above includes such syndromes as involutional psychotic reactions, psychotic depressive reactions, and probably also psychoneurotic depressions.

Prediction of clinical course of bipolar manic depressive illness treated with lithium

1980 ◽  
Vol 10 (2) ◽  
pp. 329-334 ◽  
Author(s):  
B. B. Johnston ◽  
G. J. Naylor ◽  
E. G. Dick ◽  
S. E. Hopwood ◽  
D. A. T. Dick
Keyword(s):  
Atpase Activity ◽  
Clinical Response ◽  
Poor Prognosis ◽  
Clinical Course ◽  
Lithium Concentration ◽  
Good Prognosis ◽  
Depressive Illness ◽  
Manic Depressive Illness ◽  
Manic Depressive ◽  
Depressive Patients

SYNOPSISA group of bipolar manic depressive patients attending a routine lithium clinic were investigated. The results suggest that, when on treatment with lithium, manic depressive patients with a good prognosis tend to have a higher erythrocyte Na-K ATPase and higher plasma and erythrocyte lithium concentrations than those with a poor prognosis. There was no evidence to suggest that the erythrocyte: plasma lithium ratio was useful in predicting clinical response to lithium therapy. There was also a positive correlation between plasma lithium concentration and Na–K ATPase activity, confirming that in manic depressive subjects lithium produces a rise in erythrocyte Na–K ATPase activity.

DISC HERNIA - DIFFERENTIAL DIAGNOSTICS, OPTION OF PSEUDOTUMOROUS FLOW

Vestnik ◽  
2021 ◽  
pp. 97-101
Author(s):  
М.А. Алиев ◽  
М.Ж. Мирзабаев ◽  
В.С. Караваев
Keyword(s):  
Clinical Medicine ◽  
Clinical Symptoms ◽  
Final Diagnosis ◽  
Herniated Disc ◽  
General Definition ◽  
Differential Diagnostics ◽  
Common Disease ◽  
Physical And Mental Health ◽  
Imaging Results ◽  
Definition Of

Грыжа диска (ГД) является распространенным заболеванием и наносит большой вред как физическому, так и психическому здоровью пациентов, страдающих этим заболеванием. Главным этиологическим фактором заболевания служит дегенерация диска. В настоящее время общее определение грыжи межпозвонкового диска в клинической медицине довольно запутанно. В настоящее время общее определение грыжи межпозвонкового диска в клинической медицине довольно запутанно. Окончательный диагноз ГД основывается на совокупности анамнеза, клинических симптомов и результатах визуализации. Herniated disc is a common disease and causes great harm to both the physical and mental health of patients suffering from this disease. The main etiological factor of the disease is disc degeneration. Currently, the general definition of a herniated disc in clinical medicine is quite confusing. Currently, the general definition of a herniated disc in clinical medicine is quite confusing. The final diagnosis of HD is based on a combination of anamnesis, clinical symptoms, and imaging results.

scholarly journals Myocardial infarction with nonobstructive coronary arteries

Kardiologiia ◽  
2020 ◽  
Vol 60 (3) ◽  
pp. 89-95
Author(s):  
Andrey V. Sherashov ◽  
A. S. Shilova ◽  
E. S. Pershina ◽  
D. Yu. Shchekochikhin ◽  
A. V. Svet ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Arteries ◽  
Final Diagnosis ◽  
Individual Case ◽  
Differential Diagnostics ◽  
Special Role ◽  
Disease Etiology ◽  
Magnetic Resonance Imaging Mri ◽  
Universal Definition ◽  
Definition Of

The review focused on a relatively new issue, myocardial infarction with non-obstructive coronary arteries (MINOCA). According to current ideas, almost 6% of all myocardial infarction (MI) cases may be MINOCA. This term can be used both as a “working diagnosis” at the time of further evaluation and a final diagnosis after establishing a cause for each specific case. Since some variants of cardiac, including non-coronary, pathology may be similar to MI in a number of signs, each individual case of MINOCA requires specification. Among major causes for this condition are vasospasm, CA embolism, spontaneous CA dissection, rupture of an eccentric atherosclerotic plaque in a CA, etc. Diagnostics of MINOCA includes both a set of diagnostic tests for verification of the MI diagnosis according to the Fourth Universal Definition of MI and specific studies for elaboration of the disease etiology. A special role in differential diagnostics belongs to gadolinium-enhanced magnetic-resonance imaging (MRI) of the myocardium, which allows to distinguish between MI and non-ischemic myocardial injury of different genesis. Methods of intravascular visualization, such as optical coherence tomography (OCT) and intravascular ultrasound are also important. Commonly accepted guidelines on the treatment of this pathology consistent with current ideas are not available. However, it is obvious that therapeutic possibilities and prognosis for MINOCA depend on the identified cause in each individual case.

Psychotic symptoms in pediatric bipolar disorder and family history of psychiatric illness

2006 ◽  
Vol 96 (1-2) ◽  
pp. 127-131 ◽  
Author(s):  
Richard Rende ◽  
Boris Birmaher ◽  
David Axelson ◽  
Michael Strober ◽  
Mary Kay Gill ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Family History ◽  
Psychiatric Illness ◽  
Psychotic Symptoms ◽  
Pediatric Bipolar Disorder ◽  
History Of

scholarly journals Trisomy 11 as an Additional Chromosome Alteration in a Child with Acute Promyelocytic Leukemia with Poor Prognosis

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Elenice Ferreira Bastos ◽  
Lidiane Alice Silva ◽  
Marcelo Coelho Ramos ◽  
Glicínia Pimenta ◽  
Paulo Ivo Cortez ◽  
...  
Keyword(s):  
Prognostic Significance ◽  
Good Prognosis ◽  
Promyelocytic Leukemia ◽  
Response To Treatment ◽  
Chromosome 11 ◽  
Molecular Cytogenetic ◽  
Factors Associated ◽  
The Poor ◽  
Additional Chromosome ◽  
Chromosome Alteration

The prognostic significance of the additional abnormalities to the t(15; 17) remains controversial. We report a case of promyelocytic leukemia (APL) in a ten-year-old boy. Classical and molecular cytogenetic (FISH) studies of a bone marrow sample obtained at diagnosis revealed the presence of trisomy of chromosome 11 as an additional chromosomal abnormality to the t(15; 17). The presence of the translocation t(15; 17), the cytogenetic marker of APL, is usually associated with good response to treatment with ATRA. In this case, although the patient had risk factors associated with good prognosis, he evolved and died quickly. So it seems that the presence of the trisomy 11 may be associated with disease progression and the poor outcome. To our knowledge, this is the first reported case of t(15; 17) associated with trisomy of chromosome 11 in a child with APL.

Postpartum Psychosis

2020 ◽  
pp. 39-50
Author(s):  
Nikole Benders-Hadi
Keyword(s):  
Bipolar Disorder ◽  
Family History ◽  
Elevated Risk ◽  
Psychotic Symptoms ◽  
Postpartum Psychosis ◽  
Poor Sleep ◽  
Activity Levels ◽  
History Of ◽  
Infant Hospitalization ◽  
Increased Activity

This chapter on postpartum psychosis notes that the risk of postpartum psychosis in the general population is very rare at less than 1%. In a mother with a known history of schizophrenia, this risk increases to 25%. Psychotic symptoms appearing postpartum may also be evidence of a bipolar disorder. The presence of elevated mood, increased activity levels and energy, poor sleep, and a family history of manic episodes all increase the likelihood that a bipolar disorder is present. Women with a personal or family history of a bipolar disorder are at an elevated risk of developing a mania or depression with psychotic symptoms postpartum. Postpartum psychosis due to any cause is a psychiatric emergency and treatment should be initiated early and aggressively to ensure the safety of mother and infant. Hospitalization and/or separation of the baby and mother may be necessary. The use of medication to treat schizophrenia or bipolar disorder during pregnancy may decrease the risk of a postpartum psychosis. With appropriate postpartum medication and support, the majority of women experiencing postpartum psychosis recover well and the risk of recurrent psychotic symptoms can be greatly reduced.

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