scholarly journals Antiseptic compounds: some further derivatives of anilquinoline

1928 ◽  
Vol 103 (725) ◽  
pp. 404-411 ◽  
Keyword(s):  
General Type ◽  
Present Communication ◽  
Derivatives Of

It was shown in a former paper ('Roy. Soc. Proc.,' B, vol. 96, p. 317) that a number of derivatives of amino anilquinoline acted as powerful antiseptics, being especially potent against B. coli . The present communication forms a continuation of this work, and describes further compounds of the same general type. Antiseptic power was estimated as described in the previous paper ( loc. cit. ). The results there recorded pointed to a tendency towards increased antiseptic action as the mass of the molecule was augmented, provided that the "alternate linkage system" was preserved intact.

Quinazolinone Derivatives of Biological Interest V. Novel 4(3H)-Quinazolinones with Sedative-Hypnotic, Anticonvulsant and Antiinflammatory Activities

1993 ◽  
Vol 58 (8) ◽  
pp. 1963-1968 ◽  
Author(s):  
Abdel-Alim M. Abdel-Alim ◽  
Abdel-Nasser A. El-Shorbagi ◽  
Mahmoud A. El-Gendy ◽  
Hosny A. H. El-Shareif
Keyword(s):  
Present Communication ◽  
Biological Interest ◽  
Quinazoline Derivatives ◽  
Quinazolinone Derivatives ◽  
Derivatives Of

2-Methyl-4(3H)-quinazolines carrying alkyl, cycloalkyl, aralkyl or aryl substituents at N-3 of the quinazoline ring exhibit analgetic, antipyretic and antiinflammatory activities comparable to those of aspirin and phenylbutazone. In our previous work, various 4(3H)-quinazoline derivatives were prepared. The present communication is a continuation of our effort in this field.

scholarly journals On the series of Legendre

1918 ◽  
Vol 94 (660) ◽  
pp. 292-295
Keyword(s):  
Fourier Series ◽  
General Type ◽  
General Term ◽  
Present Communication ◽  
Legendre Series ◽  
Normal Functions ◽  
Sturm Liouville ◽  
To Come ◽  
In Virtue Of

In recent communications to the Society, I have confined myself largely to the Theory of Fourier Series, partly because much seemed to me still to require doing in this subject, partly because I believed its thorough investigation to be the natural preparation for the study of other series of normal functions. It has, indeed, been known for some time that the behaviour of, for instance, series of Sturm-Liouville functions exactly corresponds to that of Fourier series. The introduction that I have recently made into Analysis of what I have called restricted Fourier series enables us to notably extend the range of such analogies. I propose in the present communication to illustrate this remark with reference to series of Legendre coefficients. Whereas Fourier series may be said to be “naturally unrestricted,” in virtue of the fact that the convergence of the integrated series to an integral necessarily involves the tendency towards zero of its own general term, so that the consideration of the more general type of series does not at once suggest itself, Legendre series may be said to come into being “restricted,” even when the coefficients are expressible in what may be called the Fourier form by means of integrals involving Legendre’s coefficients. In other words, such series correspond precisely to restricted Fourier series, instead of to ordinary Fourier series like the analogous series of Sturm-Liouville functions.

scholarly journals The antiseptic and trypanocidal action of certain styryl and anil benzthiazole derivatives

1931 ◽  
Vol 108 (755) ◽  
pp. 119-129 ◽  
Keyword(s):  
Pyridine Ring ◽  
Membered Ring ◽  
Present Series ◽  
Quinoline Derivatives ◽  
Present Communication ◽  
Quinoline Series ◽  
Derivatives Of

In view of the powerful antiseptic action of certain anil quinoline compounds (Browning, Cohen, Ellingworth and Gulbransen, 1926) and the trypanocidal action of these and especially of some styryl quinoline derivatives (Browning, Cohen, Ellingworth and Gulbransen, 1929), it was thought desirable to examine the action of similar compounds containing other heterocyclic nuclei. The present communication is concerned with a number of derivatives of benzthiazole, in which the pyridine ring of the quinoline group is replaced by a five-membered ring containing both nitrogen and sulphur. Antiseptic Action . Antiseptic power was estimated as in previous communications (Browning, Cohen, Elingworth and Gulbransen, 1926, 1928). Throughout the range of the anil benzthiazole compounds examined the antiseptic activity is considerably lower than that of the corresponding quinoline compounds. The styryl compounds tend also to be weak in their antiseptic action and in this respect resemble the styryl quinoline series, but in general they are not inferior to the latter in potency. Frequently in the present series of compounds the irregularities in action, previously commented upon, were observed in marked degree.

scholarly journals XXV.—On Meconic Acid, and some of its Derivatives

1853 ◽  
Vol 20 (3) ◽  
pp. 401-416
Author(s):  
Henry How
Keyword(s):  
Present Communication ◽  
Comenic Acid ◽  
Derivatives Of ◽  
Meconic Acid

In a paper on Comenic Acid, read before this Society in April of last year, and since honoured with a place in its Transactions, I mentioned my being engaged in an investigation on Meconic Acid; the details of the experiments referred to form the matter of the present communication.My object in undertaking this subject was to ascertain if products corresponding to those described as derived from comenic acid were formed under similar circumstances in the case of meconic acid. I also thought it probable, that as the former is itself a derivative of the latter, the changes undergone by meconic acid in some reactions, would be found to result in substances apparently the immediate derivatives of comenic acid. This remark refers to the action of heat on meconate of ammonia; and it will be seen that the expectation was realised. A similar result was found in other instances, where it had not been anticipated.

Carbon-13 nuclear magnetic resonance spectra of N-, O-, and S-methylated uracil and thiouracil derivatives

1978 ◽  
Vol 56 (5) ◽  
pp. 725-729 ◽  
Author(s):  
Ian W. J. Still ◽  
Nick Plavac ◽  
David M. McKinnon ◽  
Mohinder S. Chauhan
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Chemical Shift ◽  
General Type ◽  
Chemical Shifts ◽  
Pyrimidine Derivatives ◽  
Aromatic Substituent ◽  
Nuclear Magnetic Resonance Spectra ◽  
Derivatives Of ◽  
Thiouracil Derivatives ◽  
C Nmr

13C nmr chemical shifts have been recorded for a number of uracil, thiouracil, and pyrimidine derivatives. These data are discussed in relation to what is known of the lactam–lactim tautomerism in such systems and possible correlations of chemical shifts with normal aromatic substituent chemical shift parameters. The chemical shifts for the CH3 groups in simple methylated derivatives of uracil are very characteristic of the site of methylation and should prove useful as a tool for assigning structures to alkylated derivatives of this general type.

Titanium(IV) Complexes of Monofunctional Bidentate Schiff Bases

1970 ◽  
Vol 25 (10) ◽  
pp. 1090-1094 ◽  
Author(s):  
S. R. Gupta ◽  
J. P. Tandon
Keyword(s):  
Molecular Weight ◽  
Schiff Base ◽  
Schiff Bases ◽  
General Type ◽  
Titanium Isopropoxide ◽  
Central Metal Atom ◽  
Central Metal ◽  
Coordination Numbers ◽  
Molar Ratios ◽  
Derivatives Of

Titanium (IV) complexes of monofunctional bidentate Schiff bases, such as salicylideneaniline, β-hydroxynaphthylideneaniline, benzylidene-o-aminophenol, benzylidene-2-hydroxyethylamine and benzylidene-2-hydroxy-n-propylamine have been prepared. The reactions between titanium isopropoxide and the Schiff bases in varying molar ratios resulted in the synthesis of several new derivatives of the general type, Ti (OPri)4-x (SB)x (where x = 1. 2. 3 or 4 and SB⊖ is the anion of the Schiff base SBH) in quantitative yields. The molecular weight determinations of some of the soluble derivatives indicate the possibility of coordination numbers five or seven for the central metal atom.

scholarly journals V. Contributions to the chemistry of chlorophyll. No. V

1894 ◽  
Vol 55 (331-335) ◽  
pp. 351-356 ◽  
Keyword(s):  
Present Communication ◽  
Considerable Difficulty ◽  
Derivatives Of

My previous papers were devoted to a description of various products derived from chlorophyll and their qualitative reactions. In the present communication I propose to give an account of some experiments made with a view to ascertain the composition of some of the derivatives of chlorophyll previously described. Considerable difficulty was experienced in obtaining quantities of the various substances in a state sufficiently pure for analysis.

scholarly journals The trypanocidal action of some derivatives of anil and styryl quinoline

1929 ◽  
Vol 105 (735) ◽  
pp. 99-111 ◽  
Keyword(s):  
Therapeutic Agents ◽  
Therapeutic Action ◽  
Present Communication ◽  
Similar Treatment ◽  
Loss Of Weight ◽  
Experimentelle Therapie ◽  
Therapeutic Results ◽  
The Subject ◽  
High Degree ◽  
Derivatives Of

The powerful antiseptic action of certain basic derivatives of anil and styryl quinoline formed the subject of previous communications. The present communication is concerned with the action of a number of these substances on trypanosome infections. They constitute new types of trypanocidal agents, and in the case of certain members of the styryl series a high degree of effectiveness is attained. Biological Section . Method of Testing Therapeutic Action.—Mice infected with T. brucei were used for this purpose. They were inoculated with a suspension in saline of the blood of an infected mouse containing abundant parasites. The course of the infection was regular; on the day following inoculation the blood showed scanty trypanosomes which increased in numbers progressively, and death of the animal occurred as a rule about 72 hours was observed only very rarely. In the course of the investigation three strains of T. brucei were used, viz., Prowazek's strain obtained from the Institut für Experimentelle Therapie, Frankfurt a. Main, and two strains furnished at different times by Prof. Mesnil, Institut Pasteur, Paris, and designated Ehrlich's ferox . Care was taken to ascertain, as far as possible, by the use of standard therapeutic agents, such as arsacetin tryparosan, trypaflavin, trypanblue, and Bayer 205, that the therapeutic, results obtained with the respective strains were closely similar. Treatment was as a rule instituted on the day following inoculation, when scanty parasites were present in the blood, and consisted of a subcutaneous injection of the concentration stated in the table, in the proportion of 1 c. c. per 20 grams of body weight. To begin with a dose was chosen which approximated to the largest amount borne in uninfected animals without producing toxic effects, e. g ., loss of weight, and when only one dose is shown in the table it is this which is indicated. The blood was then examined daily for a month and at intervals afterwards for at lease 2 to 3 months before cure was recorded. The most effective substance were also tested in the chronic trypanosomiasis produced by T. brucei in rabbits.

Preparation and Characterisation of Iodo-functionalised Azobenzene Derivatives of the Type I–p-C6H4–N=N–p-C6H4–X

2008 ◽  
Vol 63 (12) ◽  
pp. 1395-1401 ◽  
Author(s):  
Ulrich Siemeling ◽  
Clemens Bruhn ◽  
Mario Meier ◽  
Christian Schirrmacher
Keyword(s):  
Single Crystal ◽  
Structure Analysis ◽  
General Type ◽  
Starting Material ◽  
Type I ◽  
X Ray Diffraction ◽  
Ferrocene Derivative ◽  
X Ray ◽  
Derivatives Of ◽  
Azobenzene Derivatives

A broad range of azobenzene derivates of the general type I-p-C6H4-N=N-p-C6H4-X (1) have been prepared. In the case of X = Ph (b), C≡C-Fc (e, Fc = ferrocenyl), OMe (g), Oi-Pr (i), and NMe2 (m), these compounds have been characterised by single-crystal X-ray structure analysis. In addition, the closely related 4-dimethylamino-1-(4-iodophenylazo)naphthalene 2 and 8-(4-iodophenylazo) quinoline 3 have also been prepared. Furthermore, the ferrocene derivative Fc-C≡C-p-C6H4- NH2 (4), which served as a starting material for the synthesis of I-p-C6H4-N=N-p-C6H4-p-C6H4- C≡C-Fc (1e), was prepared and structurally characterised by X-ray diffraction.

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