scholarly journals V. Contributions to the chemistry of chlorophyll. No. V

1894 ◽  
Vol 55 (331-335) ◽  
pp. 351-356 ◽  
Keyword(s):  
Present Communication ◽  
Considerable Difficulty ◽  
Derivatives Of

My previous papers were devoted to a description of various products derived from chlorophyll and their qualitative reactions. In the present communication I propose to give an account of some experiments made with a view to ascertain the composition of some of the derivatives of chlorophyll previously described. Considerable difficulty was experienced in obtaining quantities of the various substances in a state sufficiently pure for analysis.

Quinazolinone Derivatives of Biological Interest V. Novel 4(3H)-Quinazolinones with Sedative-Hypnotic, Anticonvulsant and Antiinflammatory Activities

1993 ◽  
Vol 58 (8) ◽  
pp. 1963-1968 ◽  
Author(s):  
Abdel-Alim M. Abdel-Alim ◽  
Abdel-Nasser A. El-Shorbagi ◽  
Mahmoud A. El-Gendy ◽  
Hosny A. H. El-Shareif
Keyword(s):  
Present Communication ◽  
Biological Interest ◽  
Quinazoline Derivatives ◽  
Quinazolinone Derivatives ◽  
Derivatives Of

2-Methyl-4(3H)-quinazolines carrying alkyl, cycloalkyl, aralkyl or aryl substituents at N-3 of the quinazoline ring exhibit analgetic, antipyretic and antiinflammatory activities comparable to those of aspirin and phenylbutazone. In our previous work, various 4(3H)-quinazoline derivatives were prepared. The present communication is a continuation of our effort in this field.

scholarly journals The antiseptic and trypanocidal action of certain styryl and anil benzthiazole derivatives

1931 ◽  
Vol 108 (755) ◽  
pp. 119-129 ◽  
Keyword(s):  
Pyridine Ring ◽  
Membered Ring ◽  
Present Series ◽  
Quinoline Derivatives ◽  
Present Communication ◽  
Quinoline Series ◽  
Derivatives Of

In view of the powerful antiseptic action of certain anil quinoline compounds (Browning, Cohen, Ellingworth and Gulbransen, 1926) and the trypanocidal action of these and especially of some styryl quinoline derivatives (Browning, Cohen, Ellingworth and Gulbransen, 1929), it was thought desirable to examine the action of similar compounds containing other heterocyclic nuclei. The present communication is concerned with a number of derivatives of benzthiazole, in which the pyridine ring of the quinoline group is replaced by a five-membered ring containing both nitrogen and sulphur. Antiseptic Action . Antiseptic power was estimated as in previous communications (Browning, Cohen, Elingworth and Gulbransen, 1926, 1928). Throughout the range of the anil benzthiazole compounds examined the antiseptic activity is considerably lower than that of the corresponding quinoline compounds. The styryl compounds tend also to be weak in their antiseptic action and in this respect resemble the styryl quinoline series, but in general they are not inferior to the latter in potency. Frequently in the present series of compounds the irregularities in action, previously commented upon, were observed in marked degree.

scholarly journals XXV.—On Meconic Acid, and some of its Derivatives

1853 ◽  
Vol 20 (3) ◽  
pp. 401-416
Author(s):  
Henry How
Keyword(s):  
Present Communication ◽  
Comenic Acid ◽  
Derivatives Of ◽  
Meconic Acid

In a paper on Comenic Acid, read before this Society in April of last year, and since honoured with a place in its Transactions, I mentioned my being engaged in an investigation on Meconic Acid; the details of the experiments referred to form the matter of the present communication.My object in undertaking this subject was to ascertain if products corresponding to those described as derived from comenic acid were formed under similar circumstances in the case of meconic acid. I also thought it probable, that as the former is itself a derivative of the latter, the changes undergone by meconic acid in some reactions, would be found to result in substances apparently the immediate derivatives of comenic acid. This remark refers to the action of heat on meconate of ammonia; and it will be seen that the expectation was realised. A similar result was found in other instances, where it had not been anticipated.

scholarly journals The trypanocidal action of some derivatives of anil and styryl quinoline

1929 ◽  
Vol 105 (735) ◽  
pp. 99-111 ◽  
Keyword(s):  
Therapeutic Agents ◽  
Therapeutic Action ◽  
Present Communication ◽  
Similar Treatment ◽  
Loss Of Weight ◽  
Experimentelle Therapie ◽  
Therapeutic Results ◽  
The Subject ◽  
High Degree ◽  
Derivatives Of

The powerful antiseptic action of certain basic derivatives of anil and styryl quinoline formed the subject of previous communications. The present communication is concerned with the action of a number of these substances on trypanosome infections. They constitute new types of trypanocidal agents, and in the case of certain members of the styryl series a high degree of effectiveness is attained. Biological Section . Method of Testing Therapeutic Action.—Mice infected with T. brucei were used for this purpose. They were inoculated with a suspension in saline of the blood of an infected mouse containing abundant parasites. The course of the infection was regular; on the day following inoculation the blood showed scanty trypanosomes which increased in numbers progressively, and death of the animal occurred as a rule about 72 hours was observed only very rarely. In the course of the investigation three strains of T. brucei were used, viz., Prowazek's strain obtained from the Institut für Experimentelle Therapie, Frankfurt a. Main, and two strains furnished at different times by Prof. Mesnil, Institut Pasteur, Paris, and designated Ehrlich's ferox . Care was taken to ascertain, as far as possible, by the use of standard therapeutic agents, such as arsacetin tryparosan, trypaflavin, trypanblue, and Bayer 205, that the therapeutic, results obtained with the respective strains were closely similar. Treatment was as a rule instituted on the day following inoculation, when scanty parasites were present in the blood, and consisted of a subcutaneous injection of the concentration stated in the table, in the proportion of 1 c. c. per 20 grams of body weight. To begin with a dose was chosen which approximated to the largest amount borne in uninfected animals without producing toxic effects, e. g ., loss of weight, and when only one dose is shown in the table it is this which is indicated. The blood was then examined daily for a month and at intervals afterwards for at lease 2 to 3 months before cure was recorded. The most effective substance were also tested in the chronic trypanosomiasis produced by T. brucei in rabbits.

scholarly journals Antiseptic compounds: some further derivatives of anilquinoline

1928 ◽  
Vol 103 (725) ◽  
pp. 404-411 ◽  
Keyword(s):  
General Type ◽  
Present Communication ◽  
Derivatives Of

It was shown in a former paper ('Roy. Soc. Proc.,' B, vol. 96, p. 317) that a number of derivatives of amino anilquinoline acted as powerful antiseptics, being especially potent against B. coli . The present communication forms a continuation of this work, and describes further compounds of the same general type. Antiseptic power was estimated as described in the previous paper ( loc. cit. ). The results there recorded pointed to a tendency towards increased antiseptic action as the mass of the molecule was augmented, provided that the "alternate linkage system" was preserved intact.

scholarly journals Morphological studies of benzene derivatives. V.—The correlation of crystalline form with molecular structure: a verification of the barlow-pope conception of "valency-volume."

1914 ◽  
Vol 90 (616) ◽  
pp. 111-173
Keyword(s):  
Molecular Structure ◽  
Internal Structure ◽  
Morphological Characters ◽  
Crystalline Form ◽  
Benzene Derivatives ◽  
Present Communication ◽  
Molecular Configuration ◽  
Morphological Studies ◽  
Derivatives Of ◽  
External Form

The systematic crystallographic inquiry discussed in the present communication was commenced, about fifteen tears ago, in the hope that it would be possible, by determining the morphological characters of a considerable number of benzene derivatives of simple constitution, to discover relationships from which definite deductions could be drawn as to the precise manner in which crystalline form is affected by particular alterations in molecular configuration—the ultimate object in view being to correlate internal structure with external form. In planning the work, in order to determine the effect of all the possible variations of the position in the molecule of chlorine and bromine, it was decided to study, in the first instance, as many as could be procured of the di-substituted compounds of the form C 6 H 3 R 1 R 2 .SO 2 X containing either chlorine of bromine in place of R 1 , R 2 and X.

scholarly journals The antiseptic properties of further amino derivatives of styryl and anil quinoline

1934 ◽  
Vol 115 (791) ◽  
pp. 1-13 ◽  
Keyword(s):  
Inhibitory Concentration ◽  
Present Series ◽  
Quinoline Derivatives ◽  
Present Communication ◽  
Lethal Action ◽  
Quaternary Salts ◽  
Amino Derivatives ◽  
Derivatives Of

The antiseptic properties of a series of quaternary salts of 2( p -amion anil or styryl) quinoline have already been described (Browning and others, 1926, 1928); the present communication is a continuation of this work. The same methods have been used as before, since with compounds of the present series also the lethal action on bacteria proceeds slowly (Browning, 1922, 1926). Table I shows the inhibitory concentration of the various substances, i. e. , the lowest concentration which suffices to inhibit growth, so that when present in the medium inoculated with the particular organism no definite turbidity to the maked eye develops after 48 hours at 37° C.—subculture the proving sterile or yielding at most a very scanty growth. As has been noted, this concentration appears to yield the most satisfactory indication of the antiseptic effect of a slowly acting bactericidal substance. 2(p- amino anil )-6 acyl amino quinoline derivatives .—Nos. 376, 374, 373, 375, 384, and 379 are analogues of 2( p -amino anil)-6 acetylamino quinoline methochlorid. (No. 45). They are all fairly powerful antiseptics toward both staphylococcus and B. coli and they are little or not at all diminished in their action by serum. The members of the series show no noteworthy progressive differences in antiseptic properties which can be attributed to alternations in the acyl group. The chloracetyl compound (No. 239) is, however, less active in serum, especially toward staphylococcus, and this corresponds with what has been found with the chloracetyl and bromacetyl derivatives of 2( p -dimethylamino anil)-6 amino quinoline ( cf . Nos. 71, 72, and 59).

Anchoring Fibrils in Arterial Endothelium

1969 ◽  
Vol 27 ◽  
pp. 274-275
Author(s):  
A. Trillo
Keyword(s):  
Carotid Arteries ◽  
Animal Species ◽  
Cell Layer ◽  
Present Communication ◽  
Internal Elastic Lamina ◽  
Endothelial Cell Layer ◽  
Structural Details ◽  
Rats And Mice ◽  
Arterial Endothelium ◽  
Elastic Lamina

There are conflicting reports regarding some fine structural details of arteries from several animal species. Buck denied the existence of a sub-endothelial space, while Karrer and Keech described a space of variable width which separates the endothelium from the underlying internal elastic lamina in aortas of aging rats and mice respectively.The present communication deals with the ultrastrueture of the interface between the endothelial cell layer and the internal elastic lamina as observed in carotid arteries from rabbits of varying ages.

Ultrastructure of NPC/HK1 cells heterotransplanted in athymic nude mice

1982 ◽  
Vol 40 ◽  
pp. 236-237
Author(s):  
E.C. Chew ◽  
C.L. Li ◽  
D.P. Huang ◽  
H.C. Ho ◽  
L.S. Mak ◽  
...  
Keyword(s):  
Cell Line ◽  
Nude Mice ◽  
Biopsy Specimen ◽  
Epithelial Cell Line ◽  
Present Communication ◽  
Recurrent Tumour ◽  
Athymic Nude Mice ◽  
Cell Line Establishment ◽  
Fine Structures ◽  
Well Differentiated

An epithelial cell line, NPC/HK1, has recently been established from a biopsy specimen of a recurrent tumour of the nasopharynx which was histologically diagnosed as a moderately to well differentiated squamous cell carcinoma. A definite decrease in the amount of tonofilaments and desmosomes in the NPC/HK1 cells during the cell line establishment was observed. The present communication reports on the fine structures of the NPC/HK1 cells heterotraneplanted in athymic nude mice.

An Established Epithelial Cell Line (NPC/HK1) from a Nasopharyngeal Carcinoma - II. A Sem Study

1982 ◽  
Vol 40 ◽  
pp. 224-225
Author(s):  
Li C.L. ◽  
Chew E.C. ◽  
Huang D.P. ◽  
Ho H.C. ◽  
Mak L.S. ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epithelial Cell ◽  
Surface Morphology ◽  
Cell Line ◽  
Epithelial Cell Line ◽  
Present Communication ◽  
Cells In Culture ◽  
Sem Study ◽  
Well Differentiated

An epithelial cell line, NPC/HK1, has recently been successfully established from a nasopharyngeal carcinoma of the moderately to well differentiated squamous type. The present communication reports on the surface morphology of the NPC/HK1 cells in culture.

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