scholarly journals The trypanocidal action of some derivatives of anil and styryl quinoline

1929 ◽  
Vol 105 (735) ◽  
pp. 99-111 ◽  
Keyword(s):  
Therapeutic Agents ◽  
Therapeutic Action ◽  
Present Communication ◽  
Similar Treatment ◽  
Loss Of Weight ◽  
Experimentelle Therapie ◽  
Therapeutic Results ◽  
The Subject ◽  
High Degree ◽  
Derivatives Of

The powerful antiseptic action of certain basic derivatives of anil and styryl quinoline formed the subject of previous communications. The present communication is concerned with the action of a number of these substances on trypanosome infections. They constitute new types of trypanocidal agents, and in the case of certain members of the styryl series a high degree of effectiveness is attained. Biological Section . Method of Testing Therapeutic Action.—Mice infected with T. brucei were used for this purpose. They were inoculated with a suspension in saline of the blood of an infected mouse containing abundant parasites. The course of the infection was regular; on the day following inoculation the blood showed scanty trypanosomes which increased in numbers progressively, and death of the animal occurred as a rule about 72 hours was observed only very rarely. In the course of the investigation three strains of T. brucei were used, viz., Prowazek's strain obtained from the Institut für Experimentelle Therapie, Frankfurt a. Main, and two strains furnished at different times by Prof. Mesnil, Institut Pasteur, Paris, and designated Ehrlich's ferox . Care was taken to ascertain, as far as possible, by the use of standard therapeutic agents, such as arsacetin tryparosan, trypaflavin, trypanblue, and Bayer 205, that the therapeutic, results obtained with the respective strains were closely similar. Treatment was as a rule instituted on the day following inoculation, when scanty parasites were present in the blood, and consisted of a subcutaneous injection of the concentration stated in the table, in the proportion of 1 c. c. per 20 grams of body weight. To begin with a dose was chosen which approximated to the largest amount borne in uninfected animals without producing toxic effects, e. g ., loss of weight, and when only one dose is shown in the table it is this which is indicated. The blood was then examined daily for a month and at intervals afterwards for at lease 2 to 3 months before cure was recorded. The most effective substance were also tested in the chronic trypanosomiasis produced by T. brucei in rabbits.

Offer of methods for minimizing key investment risks of “R-Pharm” JSC

2020 ◽  
Vol 17 (1) ◽  
pp. 58-67
Author(s):  
N. A. Kabanova ◽  
I. K. Alekseeva
Keyword(s):  
Strategic Planning ◽  
Pharmaceutical Company ◽  
Simulation Modeling ◽  
Return On Investment ◽  
System Analysis ◽  
Social Orientation ◽  
Pharmaceutical Companies ◽  
The Subject ◽  
High Degree

The article is devoted to the assessment of potential investment risks of the pharmaceutical company “R-Pharm” JSC with the aim of identifying the highest priority risks and developing methods for minimizing them. The relevance of the study is determined by the fact that the pharmaceutical business is characterized by a high degree of social orientation and annually invests $ 140 billion in the development of production and research, which determines the need for a risk-based approach to ensure the return on investment. The subject of this article is the investment risks of pharmaceutical companies, and the subject of research is the domestic pharmaceutical company “R-Pharm”. In order to assess the potential investment risks of “R-Pharm” JSC, the authors used elements of simulation modeling and system analysis. The proposed methods to minimize key investment risks are aimed at improving the efficiency of investment activities and is recommended as an element of the strategic planning of the company.

Pharmaconutrition: pharmacological approach to nutrition therapy

2014 ◽  
Vol 155 (51) ◽  
pp. 2021-2027
Author(s):  
István Télessy
Keyword(s):  
Fatty Acids ◽  
Nutritional Support ◽  
Pharmacological Action ◽  
Nutrition Therapy ◽  
Therapeutic Agents ◽  
Therapeutic Action ◽  
Treatment Results ◽  
Research Activity ◽  
Therapeutic Modalities ◽  
The Everyday

Reviewing the literature of nutrition therapy one can conclude that during the last decade the pharmacological action of several nutrients has been demonstrated. However, research activity is still at the beginning and it could be verified in a restricted number of nutrients only that in which conditions (illnesses), dose and duration we can expect therapeutic effect in addition to nutrition. The examples of glutamine, arginine, taurine, leucine, ω-3 fatty acids, however, support the possibility that complex reactions and treatment results observed in certain patients are not purely due to nutritional support but the consequence of additional pharmacological action as well. Evaluation of results of therapeutic intervention is especially difficult because in the everyday practice physicians try to use several therapeutic modalities that can be beneficial for the patient. Therefore, retrospective separation of beneficial components of the therapeutic agents is almost impossible. Only well designed, randomized and multicentric studies can verify specific therapeutic action of certain ingredients ie. nutrients. Orv. Hetil., 2014, 155(51), 2021–2027.

A Comprehensive Review on the Therapeutic Versatility of Imidazo [2,1-b]thiazoles

2020 ◽  
Vol 27 (40) ◽  
pp. 6864-6887 ◽  
Author(s):  
Mohd Adil Shareef ◽  
Irfan Khan ◽  
Bathini Nagendra Babu ◽  
Ahmed Kamal
Keyword(s):  
Literature Review ◽  
Medicinal Chemistry ◽  
Therapeutic Agents ◽  
Present Review ◽  
Thiazole Derivatives ◽  
Pharmacological Activities ◽  
Comprehensive Review ◽  
Derivatives Of

Background:: Imidazo[2,1-b]thiazole, a well-known fused five-membered hetrocycle is one of the most promising and versatile moieties in the area of medicinal chemistry. Derivatives of imidazo[2,1-b]thiazole have been investigated for the development of new derivatives that exhibit diverse pharmacological activities. This fused heterocycle is also a part of a number of therapeutic agents. Objective:: To review the extensive pharmacological activities of imidazo[2,1-b]thiazole derivatives and the new molecules developed between 2000-2018 and their usefulness. Method:: Thorough literature review of all relevant papers and patents was conducted. Conclusion:: The present review, covering a number of aspects, is expected to provide useful insights in the design of imidazo[2,1-b]thiazole-based compounds and would inspire the medicinal chemists for a comprehensive and target-oriented information to achieve a major breakthrough in the development of clinically viable candidates.

scholarly journals Hubert Maitland Turnbull, 1875-1955

1957 ◽  
Vol 3 ◽  
pp. 289-304 ◽  
Keyword(s):  
Original Work ◽  
Medical Schools ◽  
Medical College ◽  
Hospital Medical ◽  
London Hospital ◽  
The Subject ◽  
Morbid Anatomy ◽  
High Degree ◽  
Attention To Detail

Hubert Maitland Turnbull, who died on 29 September 1955 some eight years after retirement from the Chair of Morbid Anatomy at the London Hospital Medical College, occupied a position of eminence in British pathology. Not only was he greatly esteemed by his colleagues at the London but his influence extended widely throughout the medical schools of this and other countries of the Commonwealth. This was due not so much to his ability as an initiator and director of research, even though he was responsible for a considerable amount of valuable original work during his forty years at the London Hospital, but to a particular genius for accuracy of observation and meticulous attention to detail which he possessed in high degree and applied with almost religious fervour to everything that he did. Entering pathology at a time when many in this country held that morbid anatomy was a dead subject, Virchow, in their opinion, having left little new territory to be explored, Turnbull set himself to revolutionize morbid anatomical practice and to raise the subject to the level of a science. And so well did he succeed that he proved a source of inspiration not only to his fellow pathologists and those young graduates who chose to emulate him, but also to the much wider circle of clinicians who sought the privilege of working for a time in his department as a prelude to specialization in some other branch of medicine.

scholarly journals XIX.—Magnetization and Resistance of Nickel Wire at High Temperatures. Part II.

1907 ◽  
Vol 45 (3) ◽  
pp. 547-554
Author(s):  
C. G. Knott
Keyword(s):  
High Temperature ◽  
High Temperatures ◽  
Electrical Resistance ◽  
British Association ◽  
Nickel Wire ◽  
Present Communication ◽  
Association Meeting ◽  
The Subject ◽  
The Wire

The experiments which form the subject of the present communication were carried out two years ago, and supplement results already published. A brief note of some of the results was read before the Society in June 1904, and was also read before the British Association Meeting at Cambridge in August of the same year.The previous paper discussed the effect of high temperature on the relation between electrical resistance and magnetization when the wire was magnetized longitudinally, that is, in the direction in which the resistance was measured.The present results have to do with the effect of high temperature on the relation between resistance and magnetization when the magnetization was transverse to the direction along which the resistance was measured.

scholarly journals The combustion of aromatic and alicyclic hydrocarbons. II. The ignition of aromatic hydrocarbons at high temperatures

1939 ◽  
Vol 171 (946) ◽  
pp. 421-433 ◽  
Keyword(s):  
High Temperatures ◽  
Aromatic Hydrocarbons ◽  
Isothermal Oxidation ◽  
Present Communication ◽  
Temperature Range ◽  
Benzene Toluene ◽  
The Subject ◽  
Kinetics Of

In the first paper of this series (Burgoyne 1937) the kinetics of the isothermal oxidation above 400° C of several aromatic hydrocarbons was studied. The present communication extends this work to include the phenomena of ignition in the same temperature range, whilst the corresponding reactions below 400° C form the subject of further investigations now in progress. The hydrocarbons at present under consideration are benzene, toluene, ethylbenzene, n -propylbenzene, o-, m - and p -xylenes and mesitylene.

scholarly journals AN ALTERNATIVE APPROACH TO IDENTIFY KEY INDUSTRIES: ISSUES TO SELECTION CRITERIA

2014 ◽  
Vol 15 (3) ◽  
pp. 577-598
Author(s):  
Abul Quasem Al-Amin ◽  
Abdul Hamid Jaafar
Keyword(s):  
Selection Criteria ◽  
Public Investment ◽  
Correct Identification ◽  
The Public ◽  
Study Approach ◽  
Sectoral Planning ◽  
Alternative Approach ◽  
The Subject ◽  
Key Industries ◽  
High Degree

Within a process of modeling exercise, this study aimed to understand appropriate selection criteria to identify key industries. There are many key sector identification linkage measures in the subject matter and sensitivity issue among them can be tricky because many of these measures differ only slightly but can result in outcomes that are quite dissimilar. With this background, we proposed an alternate approach that helps to resolve this issue. The proposed approach utilizes in this study by five sub-methods and high degree of the frequency of their occurrences in sub-methods to determine the key sectors. The study approach is applied to Malaysia as the public sector investment remains a large share in the national economy, like other developing countries, and the correct identification is still a challenge for sectoral planning. The experiences from this study can be used to guide appropriate public investment in Malaysia and elsewhere with similar economic forms.

Quinazolinone Derivatives of Biological Interest V. Novel 4(3H)-Quinazolinones with Sedative-Hypnotic, Anticonvulsant and Antiinflammatory Activities

1993 ◽  
Vol 58 (8) ◽  
pp. 1963-1968 ◽  
Author(s):  
Abdel-Alim M. Abdel-Alim ◽  
Abdel-Nasser A. El-Shorbagi ◽  
Mahmoud A. El-Gendy ◽  
Hosny A. H. El-Shareif
Keyword(s):  
Present Communication ◽  
Biological Interest ◽  
Quinazoline Derivatives ◽  
Quinazolinone Derivatives ◽  
Derivatives Of

2-Methyl-4(3H)-quinazolines carrying alkyl, cycloalkyl, aralkyl or aryl substituents at N-3 of the quinazoline ring exhibit analgetic, antipyretic and antiinflammatory activities comparable to those of aspirin and phenylbutazone. In our previous work, various 4(3H)-quinazoline derivatives were prepared. The present communication is a continuation of our effort in this field.

Synthetic and Biological Attributes of Pyrimidine Derivatives: A Recent update

2021 ◽  
Vol 18 ◽  
Author(s):  
Meenu Devi ◽  
Shivangi Jaiswal ◽  
Sonika Jain ◽  
Navjeet Kaur ◽  
Jaya Dwivedi
Keyword(s):  
Biological Activities ◽  
Structural Diversity ◽  
Therapeutic Agents ◽  
Pyrimidine Derivatives ◽  
Diverse Range ◽  
Biological Attributes ◽  
Synthetic Approaches ◽  
High Degree ◽  
Therapeutic Activities ◽  
Anti Hiv

: Nitrogen-containing heterocycles attract the attention of chemists due to their multifarious activities. Amongst all, pyrimidine plays a central role and exhibits a broad spectrum of biological activities. Literature is replete with the various aspects of synthetic development in pyrimidine chemistry for a wide array of applications. It aroused our interest to compile various novel and efficient synthetic approaches towards the synthesis of pyrimidine and its derivatives. Pyrimidine derivatives are broadly useful as therapeutic agents, owing to their high degree of structural diversity. They have been recorded to possess a diverse range of therapeutic activities, viz. anticancer, anti-inflammatory, anti-HIV etc.

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