Neuronal Loss in a Lower Motor Neuron Disease Induced by a Murine Retrovirus
1991 ◽
Vol 18
(S3)
◽
pp. 411-413
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Keyword(s):
ABSTRACT:An animal model of neuronal loss induced by a murine retrovirus is described. The neurological disease is manifested by a lower limb paralysis and is characterized as a spongiform myeloencephalopathy. The primary determinant of neurovirulence has been mapped within the viral env sequences and a secondary determinant is present within the LTR region. A model of pathogenesis, suggesting that the disease is receptor-mediated, is proposed.
2010 ◽
Vol 49
(2)
◽
pp. 183-186
◽
2012 ◽
Vol 259
(10)
◽
pp. 2237-2239
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Keyword(s):