scholarly journals Regional Cerebral Blood Flow in Patients with Aneurysms: Estimation by Xenon 133 Inhalation

1978 ◽  
Vol 5 (3) ◽  
pp. 301-305 ◽  
Author(s):  
Bryce Weir ◽  
Devidas Menon ◽  
Thomas Overton
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Normal Values ◽  
Regional Distribution ◽  
Progressive Increase ◽  
Control Group ◽  
Regional Cerebral Blood ◽  
Progressive Reduction ◽  
Distribution Of Flow

SUMMARY:Seventy six regional cerebral blood flow (rCBF) studies were conducted on 32 patients who had a total of 39 aneurysms. Twenty three of these patients were studied pre- and post-operatively. Normal values were obtained from a control group of 33 subjects, each of whom underwent one rCBF study. Flow was reduced following subarachnoid hemorrhage (SAH); it increased significantly postoperatively. Lower flows were associated with poorer clinical grades. There was a greater variation in regional distribution of flow immediately following SAH than in normals or in patients who had recovered from the acute phase. rCBF studies correlated with CT scans demonstrated that a progressive increase in ventricular size was accompanied by a progressive reduction in flow. In addition, intraventricular hemorrhage (IVH) was associated with a significant reduction in cerebral blood flow (CBF). No significant correlation between CBF and spasm was demonstrable.

scholarly journals Changes in regional cerebral blood flow due to cognitive activation among patients with schizophrenia

2000 ◽  
Vol 177 (3) ◽  
pp. 222-228 ◽  
Author(s):  
B. K. Toone ◽  
C. I. Okocha ◽  
K. Sivakumar ◽  
G. M. Syed
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Single Photon ◽  
Photon Emission ◽  
Anterior Cingulate ◽  
Control Group ◽  
Wisconsin Card Sort Test ◽  
Card Sorting ◽  
Regional Cerebral Blood

BackgroundThe regional cerebral blood flow (rCBF) response to the Wisconsin Card Sort Test (WCST) has been used to assess the functional integrity of the prefrontal cortex in patients with schizophrenia.AimsIn this study, patients were divided into two groups according to whether they had made few or many perseverative errors on a modified version of the WCST. A control group consisted of normal volunteers. The groups were then compared with respect to rCBF response to WCST activation.MethodrCBF was measured during administration of a modified version of the WCST and during a card sorting control task, using single photon emission computerised tomography (SPECT).ResultsPerformance of the modified WCST was associated with a widespread and substantial increase in rCBF, particularly in the frontal region. The poorly performing group of patients with schizophrenia showed only a modest increase in rCBF in the left anterior cingulate region.ConclusionSubjects with schizophrenia are able to respond to specific neuropsychological challenge with activation of the frontal regions.

scholarly journals Blood Flow Differences Between Leuko-araiosis with and without Lacunar Infarction

1998 ◽  
Vol 25 (1) ◽  
pp. 70-75 ◽  
Author(s):  
Minoru Oishi ◽  
Yoko Mochizuki ◽  
Toshiaki Takasu
Keyword(s):  
Blood Flow ◽  
Cerebral Cortex ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Regional Cerebral Blood Flow ◽  
Lacunar Infarction ◽  
Cerebral White Matter ◽  
Control Group ◽  
Regional Cerebral Blood ◽  
Blood Flows

ABSTRACT:Background:The present study was designed to find the differences in regional cerebral blood flow and cerebrovascular acetazolamide reactivity between leuko-araiosis with and without lacunar infarction.Methods:Fifteen cases of leuko-araiosis with lacunar infarction, 15 cases of leuko-araiosis without lacunar infarction and 15 age-matched controls in which leuko-araiosis and cerebrovascular diseases are absent (control group) were studied. The regional cerebral blood flow was measured using the stable xenon computed tomography method before and 20 minutes after intravenous injection of 17 mg/kg acetazolamide.Results:The blood flows in the leuko-araiosis area and the lacunar area were significantly lower than the blood flow in the cerebral white matter. The blood flows in the cerebral cortex and the cerebral white matter were significantly lower in the leuko-araiosis with lacunar infarction group than in the leuko-araiosis without lacunar infarction group and the control group. The cerebrovascular acetazolamide reactivity in the leuko-araiosis area and the lacunar area was significantly lower than that in the cerebral white matter. The cerebrovascular acetazolamide reactivity in the cerebral cortex and the cerebral white matter was significantly lower in the leuko-araiosis with lacunar infarction group than in the leuko-araiosis without lacunar infarction group and the control group.Conclusions:The degree of arteriolosclerosis is considered to be more severe and the rate of association of hypertension was higher in leuko-araiosis with lacunar infarction than in leuko-araiosis without lacunar infarction.

scholarly journals Comparison of simultaneous arterial spin labeling MRI and 15O-H2O PET measurements of regional cerebral blood flow in rest and altered perfusion states

2019 ◽  
Vol 40 (8) ◽  
pp. 1621-1633 ◽  
Author(s):  
Oriol Puig ◽  
Otto M Henriksen ◽  
Mark B Vestergaard ◽  
Adam E Hansen ◽  
Flemming L Andersen ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Distribution ◽  
Regional Cerebral Blood ◽  
Non Invasive ◽  
Positron Emission ◽  
Young Subjects ◽  
Magnetic Resonance Imaging Mri ◽  
Highly Correlated

Arterial spin labelling (ASL) is a non-invasive magnetic resonance imaging (MRI) technique that may provide fully quantitative regional cerebral blood flow (rCBF) images. However, before its application in clinical routine, ASL needs to be validated against the clinical gold standard, 15O-H2O positron emission tomography (PET). We aimed to compare the two techniques by performing simultaneous quantitative ASL-MRI and 15O-H2O-PET examinations in a hybrid PET/MRI scanner. Duplicate rCBF measurements were performed in healthy young subjects ( n = 14) in rest, during hyperventilation, and after acetazolamide (post-ACZ), yielding 63 combined PET/MRI datasets in total. Average global CBF by ASL-MRI and 15O-H2O-PET was not significantly different in any state (40.0 ± 6.5 and 40.6 ± 4.1 mL/100 g/min, respectively in rest, 24.5 ± 5.1 and 23.4 ± 4.8 mL/100 g/min, respectively, during hyperventilation, and 59.1 ± 10.4 and 64.7 ± 10.0 mL/100 g/min, respectively, post-ACZ). Overall, strong correlation between the two methods was found across all states (slope = 1.01, R2 = 0.82), while the correlations within individual states and of reactivity measures were weaker, in particular in rest (R2 = 0.05, p = 0.03). Regional distribution was similar, although ASL yielded higher perfusion and absolute reactivity in highly vascularized areas. In conclusion, ASL-MRI and 15O-H2O-PET measurements of rCBF are highly correlated across different perfusion states, but with variable correlation within and between hemodynamic states, and systematic differences in regional distribution.

Effect of Histamine on Regional Cerebral Blood Flow in Man

Cephalalgia ◽  
1982 ◽  
Vol 2 (1) ◽  
pp. 15-18 ◽  
Author(s):  
Annette Æbelholt Krabbe ◽  
Jes Olesen
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Resting State ◽  
Regional Cerebral Blood Flow ◽  
Regional Distribution ◽  
Regional Cerebral Blood ◽  
Arterial Blood ◽  
Significant Change ◽  
Change In Mean

Regional cerebral blood flow (rCBF) was measured using the intra-arterial 133Xe technique in 35 or 256 areas of a hemisphere. In seven patients rCBF was measured in the resting state and following intracarotid (i.c.) infusion of histamine 10–50 μg/min. In four patients histamine was infused intravenously in a dose of 25–40 μg/min. Histamine caused no significant change in mean arterial blood pressure or arterial PCO2. There was no significant change in mean hemispheric blood flow during i.v. or i.c. histamine infusion. No change in the regional distribution of hemispheric blood flow was observed. Experimental histamine headache is most likely of extracranial origin.

scholarly journals Regional Cerebral Blood Flow Statistical Patterns and Psychological Performance in Multi-Infarct Dementia and Alzheimer’s Disease

1977 ◽  
Vol 4 (1) ◽  
pp. 53-62 ◽  
Author(s):  
Francisco I. Perez ◽  
Ninan T. Mathew ◽  
David A. Stump ◽  
John S. Mfyer
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Function Analysis ◽  
Relative Weight ◽  
Control Group ◽  
Regional Cerebral Blood ◽  
Hit Rate

SummaryMultivariate data analysis statistical procedures were applied to identify regional cerebral blood flow (rCBF) patterns in patients with multi-infarct dementia (M.I.D.) and Alzheimer’s disease (A.D.) when compared to a control group (C). A fronto-temporal-parietal pattern was identified for the A.D. group. The M.I.D. group demonstrated a predominant temporal-parietal pattern. A discriminant function analysis classified 96% of the A.D. and C. patients correctly. One hundred percent hit rate was obtained in discriminating between M.I.D. and C. Discrimination of A.D. and M.I.D. obtained 82% diagnostic accuracy. When the three groups were compared the hit rate was 93%. Mean rCBF and mean relative weight of the gray matter (Wg) differences were found when each dementia group was compared with C.M.I.D. and A.D. did not differ in mean rCBF but significant differences were found for Wg, with M.I.D. having greater reduction. The performance on standardized psychological tests of two independent samples of A.D. and M.I.D. were compared. The Memory Quotient from the Wechsler Memory Scale was consistently more impaired for the A.D. group. No correlation between degree of psychological impairment and rCBF or W g reduction was found.

Distribution of regional cerebral blood flow in voluntarily diving rats.

1998 ◽  
Vol 201 (4) ◽  
pp. 549-558
Author(s):  
G P Ollenberger ◽  
N H West
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Regional Distribution ◽  
Detailed Examination ◽  
Brain Regions ◽  
Regional Cerebral Blood ◽  
Output Only ◽  
Almost All ◽  
The Brain

The distribution of regional cerebral blood flow (rCBF) was examined in conscious, voluntarily diving rats using the brain blood flow tracer N-[14C]isopropyl-p-iodoamphetamine and quantitative autoradiography. A detailed examination of the regional distribution of cerebral blood flow revealed that almost all brain regions were hyperperfused during diving. During diving, rCBF increased by an average of 1.7-fold in 29 of the 33 brain regions examined, despite a 69.2 % decrease in cardiac output. Only some regions of the basal ganglia (caudate-putamen and globus pallidus) and limbic areas (hippocampus and amygdala) did not increase rCBF significantly during diving. We determined that the increase in rCBF during diving is primarily due to a corresponding 20.9 % decrease in cerebrovascular resistance. A significant increase in perfusion pressure during diving also potentially contributed to the increase in rCBF. Because some brain regions did not increase flow significantly during diving, these results suggest that not all brain regions participate equally in the global cerebrovascular response to diving. This study provides evidence to support the view that the brain is preferentially perfused during conscious voluntary diving in the rat. The mechanism(s) that probably produce the cerebrovascular changes during diving are discussed.

Sign in / Sign up

Export Citation Format

Share Document