scholarly journals Frequency and Cause of Parkinson’s Disease

Author(s):  
A.H. Rajput

ABSTRACT:Parkinson syndrome (PS) is a common disorder in the North American population. The annual incidence rate is 20.5/100,000 population and the mean survival after onset is approximately 12.3 years. The estimated prevalence rate is about 300/100,000 population. The incidence and prevalence rates rise with advancing age. Both the widespread use of levodopa and the improved health care in general have increased the longevity in PS. The survival in PS from the time of the first clinic visit is still significantly shorter when compared with the regional age and sex matched population. The cause of IPD may be related to some environmental factor(s) – most likely a toxin. Genetic factors are not the cause but in some families, may predispose to IPD.

The Auk ◽  
2002 ◽  
Vol 119 (3) ◽  
pp. 676-684 ◽  
Author(s):  
Michel Robert ◽  
Réjean Benoit ◽  
Jean-Pierre L. Savard

Abstract Little is known of the eastern North American population of Barrow's Goldeneyes (Bucephala islandica), which was recently listed as “of special concern” in Canada. In 1998 and 1999, we marked 18 adult males wintering along the St. Lawrence River, Québec, with satellite transmitters to document their breeding, molting, and wintering distribution and phenology, and to describe timing and routes of their spring, molt, and fall migrations. Thirteen males moved inland from the St. Lawrence River to breed; the spring migration averaged 5.9 days, and birds arrived on breeding areas on average 9 May. All breeding areas were inland, on the north shore of the St. Lawrence River estuary and gulf. Breeding areas averaged 64.8 km from the St. Lawrence corridor. Males stayed on their respective breeding area a mean of 34.5 days, and left on average 11 June. Twelve males were tracked to their molting areas, one of which stayed on its wintering area until 5 June and flew directly to its molting area. Their molt migration averaged 18.6 days, and the mean arrival date on molting areas was 30 June. All molting areas were located north and averaged 986 km from breeding areas. Four males molted in Hudson Bay, four in Ungava Bay, two in northern Labrador, one on Baffin Island, and one inland, near the Québec–Labrador border. The mean length of stay on the molting areas was 105.3 days, and the mean date of departure from molting areas was 4 October. All goldeneyes for which the radio still functioned during fall migration returned to winter in the St. Lawrence River estuary, on average 6 November. Our results refute the idea that the main breeding area of the eastern North American population of Barrow's Goldeneyes is located in northern Québec and Labrador and rather indicate that it is in the boreal forest just north of the St. Lawrence River estuary and gulf. They also indicate that Barrow's Goldeneye males undertake a genuine molt migration, and highlight the importance of molting areas because birds stayed there approximately four months each year.


2013 ◽  
Vol 97 (4) ◽  
pp. 285-287 ◽  
Author(s):  
Patrick Bates Murphy ◽  
Paul Belliveau

Abstract Acquired diverticular disease of the colon is very common in the North American population. Atypical presentations are usually due to complications and rarely the predominant complaint may be related to an associated fistula. Thigh abscesses due to colocutaneous fistula represent an uncommon complication of sigmoid diverticulitis. In rare cases, a thigh abscess may be the only symptom, but gas in the thigh should raise the index of suspicion for bowel pathology. We report the second known case of a left-sided sigmoid diverticulitis leading to an isolated right thigh abscess with no gastrointestinal symptoms.


PEDIATRICS ◽  
1992 ◽  
Vol 89 (4) ◽  
pp. 802-803
Author(s):  
J. VAN AERDE

To the Editor.— Chronic Fatigue Immune Dysfunction Syndrome (CFIDS) or Myalgic Encephalomyelitis (M.E.) is a debilitating neuroimmune disorder which is taking on epidemic proportions. Some estimates indicate that 5% of the North American population might become affected this decade. Smith et al1 confuse the symptom of "chronic fatigue" with the disease "chronic fatigue syndrome" The terminology is mixed up throughout the entire paper, but the authors clearly report on the symptom only. According to the Centers for Disease Control (CDC), the patient has to meet two major and eight minor criteria to be diagnosed with CFIDS.


2021 ◽  
Author(s):  
Robin C Orozco ◽  
Kristi Marquardt ◽  
Kerri Mowen ◽  
Linda A Sherman

The 1858C>T allele of the tyrosine phosphatase PTPN22 (causing amino acid substitution R620W in encoded protein Lyp) is present in 5-10% of the North American population and is strongly associated with numerous autoimmune diseases. Although much research has been done to define how this allele potentiates autoimmunity, the influence PTPN22 and its pro-autoimmune allele has in tumor immunity is poorly defined. To interrogate the role this allele may have in the anti-tumor immune response, we used CRISPR/Cas9 to generate mice in which the ortholog of Lyp, PEP, is mutated at position 619 to produce the relevant pro-autoimmune mutation (R619W). Results of this study show that mice homozygous for this alteration (PEP-619WW) resist tumor growth as compared with wildtype mice. Consistent with these results, tumors from PEP-619WW mice have more CD45 infiltrates containing more activated CD8 T cell and CD4 T cells. Additionally, there are more cDC1 cells and less MDSCs in tumors from PEP-619WW mice. Interestingly, the tumor infiltrating PEP-619WW cDC1s have decreased PD-L1 expression compared to cDC1s from PEP-WT mice. Taken together, our data show that the pro-autoimmune allele of Ptpn22 drives a strong anti-tumor response in innate and adaptive immune cells resulting in superior control of tumors.


2003 ◽  
Vol 85 (4) ◽  
pp. 748-758 ◽  
Author(s):  
JOSEPH A. BUCKWALTER ◽  
JAMES D. HECKMAN ◽  
DAVID P. PETRIE

2012 ◽  
Vol 63 (9) ◽  
pp. 827 ◽  
Author(s):  
Martin J. Genner ◽  
Robert Hillman ◽  
Matthew McHugh ◽  
Stephen J. Hawkins ◽  
Martyn C. Lucas

Populations of anadromous sea lamprey (Petromyzon marinus) have been found to be largely genetically homogeneous across western Europe, and across the eastern seaboard of North America. However, comparatively little is known of the relationship between the European and North American populations. We quantified the extent of population structuring present over a transatlantic scale using mitochondrial DNA sequences. We found clear segregation of the populations on either side of the Atlantic, and considerable genetic homogeneity within Europe over a spatial scale of over 2000 km. The North American populations contained larger genetic diversity than those from Europe, and coalescent analyses showed a corresponding greater overall effective population size. Employing calibration points based on a dated phylogeny of the Petromyzontiformes, our analyses indicated that the North American population has been increasing in effective size since establishment ~500 000 years ago, while the total European population has only undergone population expansion only within the last 125 000 years. This evidence is consistent with a colonisation of Europe from an older North American population, and with the European population persisting through the last glaciation within regional refugia.


2013 ◽  
Vol 118 (2) ◽  
pp. 344-349 ◽  
Author(s):  
Natalia Kraeva ◽  
Elena Zvaritch ◽  
Wanda Frodis ◽  
Olga Sizova ◽  
Alexander Kraev ◽  
...  

Abstract Background Malignant hyperthermia (MH, MIM# 145600) is a complex pharmacogenetic disorder that is manifested in predisposed individuals as a potentially lethal reaction to volatile anesthetics and depolarizing muscle relaxants. Studies of CASQ1-null mice have shown that CASQ1, encoding calsequestrin 1, the major Ca2+ binding protein in the lumen of the sarcoplasmic reticulum, is a candidate gene for MH in mice. The aim of this study was to establish whether the CASQ1 gene is associated with MH in the North American population. Methods The entire coding region of CASQ1 in 75 unrelated patients diagnosed by caffeine-halothane contracture test as MH susceptible (MHS) was analyzed by DNA sequencing. Subsequently, three groups of unrelated individuals (130 MHS, 100 MH negative, and 192 normal controls) were genotyped for a variant that was identified by sequencing. Levels of CASQ1 expression in the muscle from unrelated MHS and MH negative individuals were estimated by Western blotting. Results Screening of the entire coding sequence of the CASQ1 gene in 75 MHS patients revealed a single variant c.260T > C (p.Met87Thr) in exon 1. This variant is unlikely to be pathogenic, because its allele frequency in the MHS group was not significantly different from that of controls. There was also no difference in calsequestrin 1 protein levels between muscle samples from MHS and controls, including those carrying the p.Met87Thr variant. Conclusions This study revealed a low level of protein coding sequence variability within the human CASQ1 gene, indicating that CASQ1 is not a major MHS locus in the North American population.


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