Platelet serotonin decrease in panic disorder with obsessive compulsive symptoms

1992 ◽  
Vol 7 (1) ◽  
pp. 27-31
Author(s):  
D Servant ◽  
D Bailly ◽  
C Perret ◽  
J Vignau ◽  
PJ Parquet
Keyword(s):  
Panic Disorder ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Platelet Serotonin ◽  
Serotonergic Dysfunction

SummaryPlatelet 5-HT levels were determined by fluorescent orthophthaldehyde assay in 33 panic disorder patients with and without obsessive compulsive symptoms (PD + OCS: n = 16; PD-OCS: n = 17) according to DSM III-R criteria, and compared With those of 38 healthy controls. Mean platelet levels were significantly lower in PD + OCS than in PD-OCS patients. The results are discussed in relation to serotonergic dysfunction linked to PD and OCS comorbidity.

The inner world of overactive monitoring: neural markers of interoception in obsessive–compulsive disorder

2017 ◽  
Vol 47 (11) ◽  
pp. 1957-1970 ◽  
Author(s):  
A. Yoris ◽  
A. M. García ◽  
L. Traiber ◽  
H. Santamaría-García ◽  
M. Martorell ◽  
...  
Keyword(s):  
Panic Disorder ◽  
Obsessive Compulsive Disorder ◽  
Evoked Potential ◽  
Cognitive Profile ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Inner World ◽  
External Stimuli ◽  
Internal Body

BackgroundObsessive–compulsive disorder (OCD) patients typically overmonitor their own behavior, as shown by symptoms of excessive doubt and checking. Although this is well established for the patients’ relationship with external stimuli in the environment, no study has explored their monitoring of internal body signals, a process known to be affected in anxiety-related syndromes. Here, we explored this issue through a cardiac interoception task that measures sensing of heartbeats. Our aim was to explore key behavioral and electrophysiological aspects of internal-cue monitoring in OCD, while examining their potential distinctiveness in this condition.MethodWe administered a heartbeat detection (HBD) task (with related interoceptive confidence and awareness measures) to three matched groups (OCD patients, panic disorder patients, healthy controls) and recorded ongoing modulations of two task-relevant electrophysiological markers: the heart evoked potential (HEP) and the motor potential (MP).ResultsBehaviorally, OCD patients outperformed controls and panic patients in the HBD task. Moreover, they exhibited greater amplitude modulation of both the HEP and the MP during cardiac interoception. However, they evinced poorer confidence and awareness of their interoceptive skills.ConclusionsConvergent behavioral and electrophysiological data showed that overactive monitoring in OCD extends to the sensing of internal bodily signals. Moreover, this pattern discriminated OCD from panic patients, suggesting a condition-distinctive alteration. Our results highlight the potential of exploring interoceptive processes in the OCD spectrum to better characterize the population's cognitive profile. Finally, these findings may lay new bridges between somatic theories of emotion and cognitive models of OCD.

Obsessive-compulsive symptoms in patients with panic disorder

2004 ◽  
Vol 45 (3) ◽  
pp. 219-224 ◽  
Author(s):  
Albina Rodrigues Torres ◽  
André Marcelo Dedomenico ◽  
André Luiz Crepaldi ◽  
Eurı́pedes Constantino Miguel
Keyword(s):  
Panic Disorder ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms

Plasma prolactin response to d-fenfluramine is blunted in bulimic patients with frequent binge episodes

1998 ◽  
Vol 28 (4) ◽  
pp. 975-983 ◽  
Author(s):  
P. MONTELEONE ◽  
F. BRAMBILLA ◽  
F. BORTOLOTTI ◽  
C. FERRARO ◽  
M. MAJ
Keyword(s):  
Plasma Levels ◽  
Rating Scales ◽  
Low Frequency ◽  
Significant Negative Correlation ◽  
Plasma Prolactin ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Double Blind ◽  
Obsessive Compulsive Symptoms ◽  
Plasma Prl

Background. Abnormalities of brain serotonin (5-HT) transmission have been implicated in the pathophysiology of bulimia nervosa (BN), but no conclusive data have yet been provided. The purpose of this study was to assess 5-HT transmission via the measurement of the prolactin (PRL) response to the specific 5-HT releasing agent d-fenfluramine (d-FEN) in both patients with BN and comparison subjects.Methods. According to a double-blind placebo-controlled design, plasma PRL response to d-FEN was measured in 14 drug-free bulimics and 14 matched healthy controls. In both patients and controls, eating-related psychopathology, depressive and obsessive–compulsive symptoms, and aggressiveness were measured by rating scales.Results. Baseline plasma levels of PRL and 17β-oestradiol were significantly reduced in bulimic patients, whereas basal plasma levels of cortisol did not significantly differ from healthy controls. PRL response to d-FEN was not different between patients and controls as groups, but it was significantly blunted in bulimics with high frequency bingeing ([ges ]2 binge episodes per day; N=7) as compared to both those with low frequency bingeing ([les ]1 binge episode per day; N=7) and matched controls. A significant negative correlation emerged between the frequency of binge episodes and the hormone response to d-FEN. Moreover, although patients scored higher than healthy subjects on rating scales assessing depressive and obsessive–compulsive symptoms and aggressiveness, no significant correlation was found between these measures and the PRL response to d-FEN.Conclusions. These results support the idea that serotonin transmission is impaired in bulimic patients with frequent binge episodes.

Patterns of Reassurance Seeking and Reassurance-Related Behaviours in OCD and Anxiety Disorders

2012 ◽  
Vol 41 (1) ◽  
pp. 1-23 ◽  
Author(s):  
Osamu Kobori ◽  
Paul M. Salkovskis
Keyword(s):  
Panic Disorder ◽  
Anxiety Disorders ◽  
Obsessive Compulsive Disorder ◽  
Reliability And Validity ◽  
The Other ◽  
Self Report ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Reassurance Seeking ◽  
Compulsive Disorder

Background: Reassurance seeking is particularly prominent in obsessive-compulsive disorder (OCD) and may be important in OCD maintenance. Aims: This study used a new self-report questionnaire to measure the range of manifestations of reassurance-seeking behaviours, describing their sources from which they seek, frequency, process (how they seek), and consequences (as opposed to triggers and motivations). This study also attempts to identify the degree to which reassurance is specific to OCD as opposed to panic disorder. Method: Reassurance Seeking Questionnaire (ReSQ) was administered to 153 individuals with OCD, 50 individuals with panic disorder with/without agoraphobia, and 52 healthy controls. The reliability and validity of the measure was evaluated and found to be satisfactory. Results: Reassurance seeking was found to be more frequent in both anxiety disorders relative to healthy controls. Individuals diagnosed with OCD were found to seek reassurance more intensely and carefully, and were more likely to employ “self-reassurance” than the other two groups. Conclusions: Further investigation of reassurance will enable better understanding of its role in the maintenance of anxiety disorders in general and OCD in particular.

scholarly journals Mediating Role of Rumination and Negative Affect in the Effect of Mind-Wandering on Symptoms in Patients With Obsessive-Compulsive Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Pengchong Wang ◽  
Wenwen Cao ◽  
Tao Chen ◽  
Jian Gao ◽  
Yifan Liu ◽  
...  
Keyword(s):  
Negative Affect ◽  
Obsessive Compulsive Disorder ◽  
Mind Wandering ◽  
Healthy Controls ◽  
Response Scale ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Mediating Role ◽  
The Relationship

To explore the relationship between negative affect, mind-wandering, rumination and obsessive-compulsive symptoms, 100 patients with obsessive-compulsive disorder and 100 healthy controls were assessed using the Obsessive-Compulsive Inventory, the Beck Anxiety Inventory, the Beck Depression Inventory, the Mind Wandering Scale and the Ruminative Response Scale. The results show that (i) patients diagnosed with obsessive-compulsive disorder displayed higher obsessive-compulsive symptoms, negative affect, mind-wandering and rumination compared with healthy controls; (ii) negative affect, mind-wandering and rumination were positively correlated with the severity of obsessive-compulsive symptoms; (iii) mind-wandering predicted the severity of obsessive-compulsive symptoms (both directly and indirectly); (iv) rumination and negative affect mediated the relationship between mind-wandering and obsessive-compulsive symptoms. The results preliminarily reveal the relationship between mind-wandering and psychopathological obsessive-compulsive symptoms, providing a reference for exploring novel psychological treatments for obsessive-compulsive disorder.

Death Anxiety and Related Factors in Schizophrenia Patients: Controlled Study

2021 ◽  
pp. 003022282110331
Author(s):  
Seher Serez Öztürk ◽  
İsmet Esra Çiçek ◽  
İbrahim Eren
Keyword(s):  
Death Anxiety ◽  
Psychosocial Interventions ◽  
Anxiety Level ◽  
Controlled Study ◽  
Psychotic Symptoms ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Related Factors ◽  
Obsessive Compulsive Symptoms ◽  
Clinical Variables

The aim of the study was to investigate the level of death anxiety and related sociodemographic and clinical variables in schizophrenia patients. One hundred and ninety schizophrenia patients and 110 healthy controls were included the study. Death anxiety measured with Templer Death Anxiety Scale (TDAS). The patients were also evaluated with scales in terms of depression, anxiety, obsessive-compulsive symptoms, and suicide. The death anxiety level in patients with schizophrenia was significantly higher than the healthy controls. The severity of depressive and psychotic symptoms were related to the level of death anxiety. Patients with schizophrenia may need more protection and psychosocial interventions about death related themes.

Obsessive–compulsive disorder and separation anxiety co-morbidity in early onset panic disorder

2001 ◽  
Vol 31 (7) ◽  
pp. 1307-1310 ◽  
Author(s):  
R. GOODWIN ◽  
J. D. LIPSITZ ◽  
T. F. CHAPMAN ◽  
S. MANNUZZA ◽  
A. J. FYER
Keyword(s):  
Anxiety Disorder ◽  
Panic Disorder ◽  
Obsessive Compulsive Disorder ◽  
Separation Anxiety ◽  
Age Of Onset ◽  
Separation Anxiety Disorder ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Co Morbidity

Background. This study was undertaken to examine the relationship between anxiety co-morbidity and age of onset of panic disorder.Methods. Age of onset of panic disorder and co-morbid anxiety disorders were assessed among 201 panic disorder probands with childhood separation anxiety disorder, obsessive–compulsive disorder, obsessive–compulsive symptoms, social phobia and specific phobia as part of a clinician-administered lifetime diagnostic interview. A generalized linear model was used to test the association between each anxiety co-morbidity and age of panic disorder onset while simultaneously controlling for the potential confounding effects of sociodemographic characteristics and other psychiatric co-morbidity.Results. Earlier onset of panic disorder was found in patients with co-morbid obsessive–compulsive disorder, obsessive–compulsive symptoms and separation anxiety disorder, but not simple phobia or social phobia. Patients with both childhood separation anxiety disorder and obsessive–compulsive disorder had an even earlier panic onset than those with either childhood separation anxiety disorder or obsessive–compulsive disorder.Conclusions. The association between anxiety co-morbidity and earlier onset of panic disorder is specific to obsessive–compulsive disorder and childhood separation anxiety disorder.

Magical Thinking in Obsessive-Compulsive Disorder, Panic Disorder and the General Community

2006 ◽  
Vol 34 (3) ◽  
pp. 351-357 ◽  
Author(s):  
Danielle A. Einstein ◽  
Ross G. Menzies
Keyword(s):  
Panic Disorder ◽  
Obsessive Compulsive Disorder ◽  
Normal Subjects ◽  
Control Group ◽  
Short Version ◽  
Magical Thinking ◽  
Obsessive Compulsive ◽  
Magical Ideation ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder

Magical Ideation was examined in 71 individuals across four groups matched, where possible, for gender and age. These groups were: (1) Obsessive Compulsive Disorder (OCD) patients with cleaning compulsions (n = 11); (2) OCD patients with checking compulsions (n = 20); (3) panic disorder patients with minimal obsessive compulsive symptoms (n = 19); (4) a “normal” control group with minimal obsessive compulsive symptoms (n = 21). The Magical Ideation Scale (MI, Eckblad and Chapman, 1983), the Obsessive Compulsive Inventory- Short Version (OCI-SV; Foa et al., 2002) and the Maudsley Obsessional-Compulsive Inventory (MOCI, Hodgson and Rachman, 1977) were administered to all participants. A one-way Anova was conducted with four planned contrasts. As expected, the OCD groups obtained magical ideation scores higher than the normal subjects. This suggests that OCD patients engage in more magical thinking tendencies than non-anxious controls. Similarly, OCD participants obtained a mean magical ideation score significantly higher than the panic disorder group, suggesting that obsessional compulsive patients are more likely to exhibit magical thinking than individuals with panic disorder. Of note, panic disorder and control group means on MI did not differ significantly. Finally, individuals with obsessive cleaning compulsions displayed higher levels of magical thinking compared to individuals with obsessive checking compulsions, despite no difference in severity of their obsessive compulsive symptoms. This observation was counter to previous findings (Einstein and Menzies, 2004a; Einstein and Menzies, 2004b).

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