scholarly journals Intra-familial transmission of life-threatening group A streptococcal infection

2002 ◽  
Vol 129 (2) ◽  
pp. 303-306 ◽  
Author(s):  
R. A. RECCO ◽  
M. M. ZAMAN ◽  
H. CORTES ◽  
J. COLUCCI ◽  
G. POOMKUDY ◽  
...  
Keyword(s):  
Health Care Workers ◽  
Streptococcal Infection ◽  
Invasive Infection ◽  
Additional Consideration ◽  
Invasive Group ◽  
The Past ◽  
Care Workers ◽  
Life Threatening ◽  
Group A ◽  
Close Contacts

Invasive group A streptococcal (GAS) infections have been of increasing concern worldwide during the past 15 years. Spread of group A streptococci to contacts with resulting invasive infection has been reported in families, in residential nursing homes, and even from patients to health care workers. We report an instance of temporally related life-threatening group A streptococcal infection in a husband and 2 weeks later in his wife. This example further emphasizes the need for careful observation among family members and other close contacts of patients with invasive group A streptococcal infection. Although at present there are no universal recommendations for monitoring or for antibiotic prophylaxis of close contacts of persons with invasive GAS infection, when added to existing literature, this report suggests additional consideration is required.

scholarly journals Flesh-Eating Disease: A Note on Necrotizing Fasciitis

2001 ◽  
Vol 12 (3) ◽  
pp. 136-140 ◽  
Author(s):  
H Dele Davies
Keyword(s):  
Necrotizing Fasciitis ◽  
Present Note ◽  
Paediatric Society ◽  
Invasive Group ◽  
Media Attention ◽  
The Past ◽  
Current State ◽  
Muscle Necrosis ◽  
Group A ◽  
Close Contacts

There has been much media attention in the past few years to the condition dubbed 'flesh-eating disease', which refers, primarily, to a form of invasive group A beta hemolytic streptococcal (GABHS) infection that leads to fascia and muscle necrosis. In 1999, the Canadian Paediatric Society issued a statement on the state of knowledge and management of children, and close contacts of persons with all-invasive GABHS disease (1). The present note is intended to deal specifically with necrotizing fasciitis (NF) by providing an update on the limited current state of knowledge, diagnosis and management. Surveillance to establish actual national rates and epidemiology of NF through the Canadian Paediatric Society is proposed.

scholarly journals Risk Factors in the Pathogenesis of Invasive Group A Streptococcal Infections: Role of Protective Humoral Immunity

1999 ◽  
Vol 67 (4) ◽  
pp. 1871-1877 ◽  
Author(s):  
Hesham Basma ◽  
Anna Norrby-Teglund ◽  
Yajaira Guedez ◽  
Allison McGeer ◽  
Donald E. Low ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Streptococcal Infection ◽  
Host Susceptibility ◽  
Streptococcal Toxic Shock Syndrome ◽  
Invasive Infection ◽  
Streptococcal Infections ◽  
Invasive Group ◽  
Invasive Infections ◽  
Protective Antibodies ◽  
Group A

ABSTRACT An impressive change in the epidemiology and severity of invasive group A streptococcal infections occurred in the 1980s, and the incidence of streptococcal toxic shock syndrome cases continues to rise. The reason for the resurgence of severe invasive cases remains a mystery—has there been a change in the pathogen or in host protective immunity? To address these questions, we have studied 33 patients with invasive infection caused by genotypically indistinguishable M1T1 strains of Streptococcus pyogenes who had different disease outcomes. Patients were classified as having severe (n= 21) and nonsevere (n = 12) invasive infections based on the presence or absence of shock and organ failure. Levels of anti-M1 bactericidal antibodies and of anti-streptococcal superantigen neutralizing antibodies in plasma were significantly lower in both groups than in age- and geographically matched healthy controls (P < 0.01). Importantly, the levels of these protective antibodies in plasma samples from severe and nonsevere invasive cases were not different. Together the data suggest that low levels of protective antibodies may contribute to host susceptibility to invasive streptococcal infection but do not modulate disease outcome. Other immunogenetic factors that regulate superantigen responses may influence the severity of systemic manifestations associated with invasive streptococcal infection.

scholarly journals An Outbreak of Group A Streptococcal Infection among Health Care Workers

2002 ◽  
Vol 35 (11) ◽  
pp. 1353-1359 ◽  
Author(s):  
Anthony Kakis ◽  
Laurel Gibbs ◽  
Jose Eguia ◽  
Joe Kimura ◽  
Diane Vogelei ◽  
...  
Keyword(s):  
Health Care ◽  
Health Care Workers ◽  
Streptococcal Infection ◽  
Care Workers ◽  
Group A

Invasive group A streptococcal infection in pregnancy

2010 ◽  
Vol 60 (6) ◽  
pp. 417-424 ◽  
Author(s):  
Takahiro Yamada ◽  
Takashi Yamada ◽  
Mie K. Yamamura ◽  
Kenichi Katabami ◽  
Mineji Hayakawa ◽  
...  
Keyword(s):  
Streptococcal Infection ◽  
Invasive Group ◽  
Group A ◽  
In Pregnancy

Invasive Group-A Streptococcal Infection in an Allograft Recipient

2007 ◽  
Vol 89 (9) ◽  
pp. 2044-2047 ◽  
Author(s):  
Ellen H. Lee ◽  
Dayna Ferguson ◽  
Anne Schuchat ◽  
Bernard Beall ◽  
Daniel Jernigan ◽  
...  
Keyword(s):  
Streptococcal Infection ◽  
Invasive Group ◽  
Group A

scholarly journals Age-related differences in clinical characteristics of invasive group G streptococcal infection: Comparison with group A and group B streptococcal infections

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0211786 ◽  
Author(s):  
Yoshihiro Fujiya ◽  
Kayoko Hayakawa ◽  
Yoshiaki Gu ◽  
Kei Yamamoto ◽  
Momoko Mawatari ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Streptococcal Infection ◽  
Streptococcal Infections ◽  
Invasive Group ◽  
Age Related ◽  
Group A ◽  
Group B

scholarly journals Case of Necrotizing Myositis in Upper Extremity due to Invasive Group A Streptococcal Infection.

1997 ◽  
Vol 46 (1) ◽  
pp. 195-197
Author(s):  
Tomomasa Kajikawa ◽  
Tatsuhiko Henmi ◽  
Yoshiji Kanematsu ◽  
Rintaro Sakamoto ◽  
Koichi Sairyo ◽  
...  
Keyword(s):  
Upper Extremity ◽  
Streptococcal Infection ◽  
Invasive Group ◽  
Necrotizing Myositis ◽  
Group A

Invasive group A streptococcal infection

2010 ◽  
Vol 92-B (6) ◽  
pp. 763-769 ◽  
Author(s):  
C. N. Brown ◽  
T. C. B. Pollard ◽  
S. Iyer ◽  
A. J. M. D. Andrade
Keyword(s):  
Streptococcal Infection ◽  
Invasive Group ◽  
Group A

scholarly journals Streptococcus pyogenes evades adaptive immunity through specific IgG glycan hydrolysis

2019 ◽  
Vol 216 (7) ◽  
pp. 1615-1629 ◽  
Author(s):  
Andreas Naegeli ◽  
Eleni Bratanis ◽  
Christofer Karlsson ◽  
Oonagh Shannon ◽  
Raja Kalluru ◽  
...  
Keyword(s):  
Streptococcus Pyogenes ◽  
Vaccine Development ◽  
Group A Streptococcus ◽  
Invasive Infection ◽  
Invasive Infections ◽  
Life Threatening ◽  
Group A ◽  
Specific Igg

Streptococcus pyogenes (Group A streptococcus; GAS) is a human pathogen causing diseases from uncomplicated tonsillitis to life-threatening invasive infections. GAS secretes EndoS, an endoglycosidase that specifically cleaves the conserved N-glycan on IgG antibodies. In vitro, removal of this glycan impairs IgG effector functions, but its relevance to GAS infection in vivo is unclear. Using targeted mass spectrometry, we characterized the effects of EndoS on host IgG glycosylation during the course of infections in humans. Substantial IgG glycan hydrolysis occurred at the site of infection and systemically in the severe cases. We demonstrated decreased resistance to phagocytic killing of GAS lacking EndoS in vitro and decreased virulence in a mouse model of invasive infection. This is the first described example of specific bacterial IgG glycan hydrolysis during infection and thereby verifies the hypothesis that EndoS modifies antibodies in vivo. This mechanisms of immune evasion could have implications for treatment of severe GAS infections and for future efforts at vaccine development.

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