scholarly journals Age-related differences in clinical characteristics of invasive group G streptococcal infection: Comparison with group A and group B streptococcal infections

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0211786 ◽  
Author(s):  
Yoshihiro Fujiya ◽  
Kayoko Hayakawa ◽  
Yoshiaki Gu ◽  
Kei Yamamoto ◽  
Momoko Mawatari ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Streptococcal Infection ◽  
Streptococcal Infections ◽  
Invasive Group ◽  
Age Related ◽  
Group A ◽  
Group B

scholarly journals Clinical and epidemiological features of group A streptococcal bacteraemia in a region with hyperendemic superficial streptococcal infection

1999 ◽  
Vol 122 (1) ◽  
pp. 59-65 ◽  
Author(s):  
J. R. CARAPETIS ◽  
A. M. WALKER ◽  
M. HIBBLE ◽  
K. S. SRIPRAKASH ◽  
B. J. CURRIE
Keyword(s):  
Streptococcal Infection ◽  
Northern Territory ◽  
Streptococcal Infections ◽  
Invasive Group ◽  
Genetic Typing ◽  
Aboriginal Population ◽  
Epidemiological Features ◽  
Significant Difference ◽  
Group A ◽  
Study Population

Reports of increasing incidence and severity of invasive group A streptococcal (GAS) infections come mainly from affluent populations where exposure to GAS is relatively infrequent. We conducted a 6-year retrospective review of GAS bacteraemia in the Northern Territory of Australia, comparing the Aboriginal population (24% of the study population), who have high rates of other streptococcal infections and sequelae, to the non-Aboriginal population. Of 72 episodes, 44 (61%) were in Aboriginal patients. All 12 cases in children were Aboriginal. Risk factors were implicated in 82% of episodes (91% in adults) and there was no significant difference in the proportion of Aboriginal compared to non-Aboriginal patients with at least one risk factor. Genetic typing of isolates revealed no dominant strains and no evidence of a clone which has been a common cause of these infections elsewhere.

scholarly journals Risk Factors in the Pathogenesis of Invasive Group A Streptococcal Infections: Role of Protective Humoral Immunity

1999 ◽  
Vol 67 (4) ◽  
pp. 1871-1877 ◽  
Author(s):  
Hesham Basma ◽  
Anna Norrby-Teglund ◽  
Yajaira Guedez ◽  
Allison McGeer ◽  
Donald E. Low ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Streptococcal Infection ◽  
Host Susceptibility ◽  
Streptococcal Toxic Shock Syndrome ◽  
Invasive Infection ◽  
Streptococcal Infections ◽  
Invasive Group ◽  
Invasive Infections ◽  
Protective Antibodies ◽  
Group A

ABSTRACT An impressive change in the epidemiology and severity of invasive group A streptococcal infections occurred in the 1980s, and the incidence of streptococcal toxic shock syndrome cases continues to rise. The reason for the resurgence of severe invasive cases remains a mystery—has there been a change in the pathogen or in host protective immunity? To address these questions, we have studied 33 patients with invasive infection caused by genotypically indistinguishable M1T1 strains of Streptococcus pyogenes who had different disease outcomes. Patients were classified as having severe (n= 21) and nonsevere (n = 12) invasive infections based on the presence or absence of shock and organ failure. Levels of anti-M1 bactericidal antibodies and of anti-streptococcal superantigen neutralizing antibodies in plasma were significantly lower in both groups than in age- and geographically matched healthy controls (P < 0.01). Importantly, the levels of these protective antibodies in plasma samples from severe and nonsevere invasive cases were not different. Together the data suggest that low levels of protective antibodies may contribute to host susceptibility to invasive streptococcal infection but do not modulate disease outcome. Other immunogenetic factors that regulate superantigen responses may influence the severity of systemic manifestations associated with invasive streptococcal infection.

scholarly journals Profile of invasive group A and group B Streptococcal infections in patients hospitalized at the University Hospital for Infectious Diseases „Dr. Fran Mihaljević“ during the period from 2011 to 2018

2020 ◽  
Vol 40 (1) ◽  
pp. 11-14
Author(s):  
Lana Šepec Rožmarić ◽  
Suzana Bukovski
Keyword(s):  
Infectious Diseases ◽  
Invasive Disease ◽  
University Hospital ◽  
Age Group ◽  
Streptococcal Infections ◽  
Invasive Group ◽  
Common Cause ◽  
Group A ◽  
Group B ◽  
The University

Aim: Beta-haemolytic streptococci (BHS) rarely cause invasive disease (ID). Usually the most common cause of ID is group B BHS (BHS-B). However, in our recent routine work higher number of group A BHS (BHS-A) isolates from blood was noted. The aim of this study was to report trends and findings by group BHS-A and BHS-B causing laboratory confirmed disease from 2011 to 2018 at the University Hospital for Infectious Diseases „Dr. Fran Mihaljević”. Methods: Data on patients from the electronic database of microbiological laboratory at UHID for the period 2011-2018 was collected and analysed. Results: During the period 2011-2018, 151 BHS A and B were identified from normally sterile body sites. Most isolates were from blood cultures (96.7%). BHS-A and BHS-B were isolated almost equally. The highest number of isolates was recorded in 2012 and 2017. The number of BHS A isolates peaked in 2012, 54% more than BHS-B, and 50% more in 2016. Children presented 19.9% of patients, and were mostly isolated with BHS-A. 80.1% patients were adults. Adults predominated in the age group &gt;65 years. 12 children and 18 adults were hospitalised in intensive care unit. Conclusion: Invasive group A and group B streptococcal infections predominantly affect most vulnerable age groups, children and elderly. In this study invasive BHS disease is most common among adults above 65 years of age. BHS-A was most common cause of invasive disease among paediatric patients as well as in the age group above 65 years. Typing and characterization of BHS-A isolates due to its characteristics should be foreseen as important diagnostic tool, especially to monitor changes in virulence and to prevent potential outbreaks.

scholarly journals Molecular and Clinical Characteristics of Invasive Group A Streptococcal Infection in Sweden

2007 ◽  
Vol 45 (4) ◽  
pp. 450-458 ◽  
Author(s):  
J. Darenberg ◽  
B. Luca-Harari ◽  
A. Jasir ◽  
A. Sandgren ◽  
H. Pettersson ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Streptococcal Infection ◽  
Invasive Group ◽  
Group A

Age related volume of cadaver-prostates in Bangladesh

1970 ◽  
Vol 4 (2) ◽  
pp. 74-77
Author(s):  
Rukshana Ahmed ◽  
Shamim Ara
Keyword(s):  
Prostate Gland ◽  
Age Groups ◽  
Clinical Settings ◽  
Cross Sectional ◽  
Medical College ◽  
Age Related ◽  
Group A ◽  
Key Words Prostate ◽  
The Mean ◽  
Group B

Pathological changes in the prostate gland occur commonly with advancing age including inflammation, atrophy, hyperplasia and carcinoma and a change in volume is also evident. Estimation of volume of prostate may be useful in a variety of clinical settings. A cross-sectional descriptive study was designed to see the changes in volume of the prostate with advancing age and done in the Department of Anatomy, Dhaka Medical College, Dhaka from August 2006 to June 2007. The study was performed on 70 post-mortem human prostates collected from the unclaimed dead bodies that were under examination in the Department of Forensic Medicine, Dhaka Medical College, Dhaka. The samples were divided into three age groups; group A (10-20 years), group B (21-40 years) and group C (41-70 years). Volume of the sample was measured by using the ellipsoid formula. The mean ± SD volume of prostate was 7.68 ± 3.64 cm3 in group A, 10.61 ± 3.99 cm3 in group B and 15.40 ± 6.31 cm3 in group C. Mean difference in volume between group A and group C, group B and group C were statistically significant (p<0.001). Statistically significant positive correlation was found between age and volume of prostate (r = + 0.579, p < 0.001). Key Words: Prostate; volume; Bangladeshi. DOI: 10.3329/imcj.v4i2.6501Ibrahim Med. Coll. J. 2010; 4(2): 74-77

Invasive Group A Streptococcal infections in children

2020 ◽  
Vol 16 ◽  
Author(s):  
Molla Imaduddin Ahmed ◽  
Rosalind V Saunders ◽  
Srini Bandi
Keyword(s):  
Early Diagnosis ◽  
Management Practices ◽  
Clinical Presentation ◽  
Streptococcal Infections ◽  
Invasive Group ◽  
Children's Hospital ◽  
Good Outcome ◽  
Children’S Hospital ◽  
Group A

: We reviewed the clinical presentation and management of children with Invasive group A streptococcal infections admitted to our tertiary Children’s Hospital in the last eight years. Our study highlighted the varied symptomatology and management practices in children with iGAS and showed that early diagnosis and prompt initiation of appropriate antibiotics for iGAS can help in resolution of symptoms and good outcome.

Invasive group A streptococcal infection in pregnancy

2010 ◽  
Vol 60 (6) ◽  
pp. 417-424 ◽  
Author(s):  
Takahiro Yamada ◽  
Takashi Yamada ◽  
Mie K. Yamamura ◽  
Kenichi Katabami ◽  
Mineji Hayakawa ◽  
...  
Keyword(s):  
Streptococcal Infection ◽  
Invasive Group ◽  
Group A ◽  
In Pregnancy

COMMENTS ON DR. KLEIN'S PAPER

PEDIATRICS ◽  
1973 ◽  
Vol 51 (2) ◽  
pp. 390-390
Keyword(s):  
Air Force ◽  
Streptococcal Infection ◽  
Staphylococcal Infection ◽  
Klein Group ◽  
Significant Difference ◽  
Group A ◽  
Air Force Base ◽  
Group B ◽  
Antibiotic Ointment ◽  
Boston Hospital

Dr. Ribble: In this study was the umbilicus included in bathing of the "diaper area"? Dr. Klein: Yes. Dr. Ribble: Have epidemics of streptococcal disease occured in nurseries in which hexachlorophene bathing was being carried out? Dr. Klein: Group B beta hemolytic streptococcal infections have been reported in nurseries where hexachlorophene bathing was being used. Dr. Schaberg: We have had cultural evidence of the presence of Group A streptococcal infection in infants on hexachlorophene bathing, and another Boston hospital had a nursery epidemic of Group A streptococcal infection in 1967 while using hexachlorophene bathing. Dr. Gezon: Mortimer also reported an epidemic occurring in a nursery where only the babies' faces were washed with hexachlorophene. Leadbetter's data from Lackland Air Force Base showed that he was unable to stop an epidemic of staphylococcal infection with intensive hexachlorophene bathing, including washing the umbilicus three times a day with hexachlorophene. He was also unable to get a significant difference in colonization rates when half the infants were washed with hexachlorophene and half were not. Dr. Gezon: Attention to the umbilicus is very important in controlling staphylococcal infection in the newborn. Jellard has shown this with triple dye, Gillespie with hexachlorophene powder, and Mortimer with antibiotic ointment applied to the umbilicus.

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