The seroprevalence of parvovirus B19 infection in pregnant women in Sudan

2014 ◽  
Vol 143 (2) ◽  
pp. 242-248 ◽  
Author(s):  
O. ADAM ◽  
T. MAKKAWI ◽  
U. REBER ◽  
H. KIRBERG ◽  
A. M. EIS-HÜBINGER
Keyword(s):  
Pregnant Women ◽  
Parvovirus B19 ◽  
Fetal Loss ◽  
Epidemiological Data ◽  
Adverse Outcomes ◽  
Hydrops Fetalis ◽  
Enzyme Immunoassays ◽  
Igm Antibodies ◽  
Parvovirus B19 Infection ◽  
Antenatal Clinics

SUMMARYParvovirus B19 (B19V) infection during pregnancy may have serious consequences like fetal anaemia, hydrops fetalis, and fetal loss. Since epidemiological data on B19V infection are generally lacking in Sudan, the current study aimed to determine the seroprevalence of B19V in Sudanese pregnant women. Five hundred women, attending antenatal clinics in Khartoum state between November 2008 and March 2009, were enrolled and screened for B19V IgG and IgM antibodies by enzyme immunoassays. The study revealed a B19V IgG seroprevalence of 61·4%, with one subject positive for IgM. B19V DNA was not detected by PCR in any of the tested individuals. B19V IgG seroprevalence was significantly correlated with multigravidity (P = 0·046). Our data showed that B19V infection is prevalent in Sudan and we recommend further studies in Sudanese women, particularly in those with complications and adverse outcomes of pregnancy.

scholarly journals The magnitude and correlates of Parvovirus B19 infection among pregnant women attending antenatal clinics in Mwanza, Tanzania

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Mariam M. Mirambo ◽  
Fatma Maliki ◽  
Mtebe Majigo ◽  
Martha F. Mushi ◽  
Nyambura Moremi ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Parvovirus B19 ◽  
Parvovirus B19 Infection ◽  
Antenatal Clinics

scholarly journals PREVALENCE OF HUMAN PARVOVIRUS B19 IgG AND IgM ANTIBODIES AMONG PREGNANT WOMEN ATTENDING ANTENATAL CLINIC AT FEDERAL TEACHING HOSPITAL IDO-EKITI, NIGERIA.

2021 ◽  
Vol 15 (2) ◽  
pp. 10-15
Author(s):  
Richard Yomi Akele ◽  
Jennifer Tamuno Abelekum ◽  
Bernard Oluwapelum Oluboyo ◽  
Janet Funmilayo Akinseye ◽  
Seyi Samson Enitan ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Pregnant Women ◽  
Teaching Hospital ◽  
Parvovirus B19 ◽  
Epidemiological Data ◽  
Antenatal Clinic ◽  
Assay Method ◽  
Enzyme Linked Immunosorbent Assay ◽  
Human Parvovirus B19 ◽  
Igm Antibodies

Background: Human Parvovirus B19 (B19V) is a DNA virus, transmitted through respiratory secretions, hand-to-mouth-contact, blood transfusion and trans-placental transfer. It causes high mortality and morbidity in pregnant women, thus contributing to poor maternal and child health. B19V has been neglected due to dearth of epidemiological data. The aim of this study was to determine the sero-prevalence of Human Parvovirus B19 antibodies among pregnant women attending antenatal clinic at Federal Teaching Hospital Ido-Ekiti, Nigeria. Materials and Methods: This cross-sectional study enrolled pregnant women attending Federal Teaching Hospital Ido-Ekiti from January to May 2019 to obtain sero-epidemiological data. One hundred and twenty-two (122) consenting pregnant women were enrolled following institutional ethical approval. They were administered structured questionnaire and venous blood was collected in plain tubes for serum extraction. Sera samples were analyzed for IgG and IgM antibodies using the enzyme linked immunosorbent assay method. Percentages, median, chi-square and multivariate analysis were carried out using SPSS version 17. Results: The prevalence of IgG was 44.3% (54/122), IgM 41.8% (51/122), and IgG/IgM 28.7% (35/122) leaving 55.7% (68/122) of the population uninfected. The median age of participants was 22 (Interquartile range 18-25) years among which 36-45years had the highest prevalence which was not statistically significant (p=0.09 4.75). There was association between miscarriage, still birth, history of blood transfusion and prevalence of Human Parvovirus B19 (p<0.05). Conclusion: There is a high Prevalence of B19V among pregnant women attending antenatal clinic in this study. This underscores the need for testing and immunization of pregnant women against B19V.

Case 39

2020 ◽  
pp. 269-276
Author(s):  
Katie Jeffery
Keyword(s):  
Viral Infection ◽  
Viral Infections ◽  
Parvovirus B19 ◽  
Adverse Outcomes ◽  
Varicella Zoster ◽  
Parvovirus B19 Infection ◽  
Diagnostic Approaches ◽  
In Pregnancy

Viral infection in pregnancy can lead to adverse outcomes for both the mother and the foetus. This chapter examines the steps to be taken on exposure to viruses associated with rash illness in pregnancy. Consideration is given to the important points in the history, which viral infections are of concern in pregnancy (varicella-zoster, parvovirus B19, rubella, measles, and Zika), the possible outcomes of infection, diagnostic approaches, and the management of a confirmed case of Parvovirus B19 infection.

scholarly journals Seroprevalence of anti-Parvovirus B19 IgG in childbearing age women in Pleven region (Bulgaria)

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
T Petkova ◽  
S Pachkova ◽  
T z Doichinova ◽  
S Aleksandrova-Yankulovska
Keyword(s):  
Pregnant Women ◽  
Parvovirus B19 ◽  
Specific Treatment ◽  
Case Report Form ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Active Monitoring ◽  
Populations At Risk ◽  
Parvovirus B19 Infection ◽  
Childbearing Age Women

Abstract Background Parvovirus B19 is a widespread infection in childhood. Seroprevalence of anti-Parvovirus B19 increases with age and about 60% to 70% of women of childbearing age have serological evidence of past exposure to virus. Diaplacental Parvovirus B19 infection in pregnant women can lead to anaemia, non-immune hydrops fetalis and foetal death. The aim of the study is determining the susceptibility to Parvovirus B19 in childbearing age women. Methods We conducted a prospective seroepidemiological study in which 90 healthy women of childbearing age (19 to 40 years) were tested during the period September-October 2018 in Medical Center “Clinical Institute for Reproductive Medicine”- Pleven, Bulgaria. Participants were surveyed on a voluntary basis. The exclusion criteria were: presence of autoimmune disorder, immunosuppressive states, malignancy and populations at risk such as persons under 18 years of age and pregnant women. The presence of specific Parvovirus B19 IgG was detected using a standardized anti-Parvovirus B19 (IgG) ELISA kit. The demographic and anamnestic data were collected for each participant in Case Report Form. Results The average age of the women was 31.4 ± 4.9 years. Dominating were women with higher education (52.2%) living in urban areas (92.2%). The survey results showed that 37.8% of women were positive for anti-Parvovirus B19 IgG, 61.1% were negative and 1.1% equivocal. Immunty to the virus increased from 27.3% to 45% with age. There was no significant correlation between the presence of antibodies and the demographic factors (living area, education and number of family members). Conclusions The results of this study imply that 61.1% of the childbearing age women in Pleven region are susceptible to infection with Parvovirus B19. Because of the high susceptibility to Parvovirus B19, active monitoring of risk groups pregnant women for the prevention of fetal complications is recommended. Key messages There is no specific treatment or prophylaxis against Parvovirus B19 infection and epidemiological surveillance requires the introduction of effective preventive measures at the public health level. Active monitoring in childbearing age women is necessary to reduce the risk of fetal damage and the cost of healthcare associated with the infection.

Parvovirus Infects Cardiac Myocytes in Hydrops Fetalis

2003 ◽  
Vol 6 (5) ◽  
pp. 414-420 ◽  
Author(s):  
Aiveen O'Malley ◽  
Carole Barry-Kinsella ◽  
Caroline Hughes ◽  
Peter Kelehan ◽  
Deirdre Devaney ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Cardiac Myocytes ◽  
Cardiac Tissue ◽  
Parvovirus B19 ◽  
Negative Control ◽  
Hydrops Fetalis ◽  
Immunogold Electron Microscopy ◽  
Erythroid Precursor ◽  
Transmission Electron ◽  
Parvovirus B19 Infection

Parvovirus infection during pregnancy is an important cause of hydrops fetalis. It is attributed to anemia caused by viral-induced destruction of red blood cells. Infection of other organs has been reported including the heart, liver, and lungs. Few of these reports, however, convincingly demonstrate virions within the functional parenchyma of the tissue. This is of particular concern regarding myocardium in the context of hydrops fetalis which is, in part, due to cardiac failure. The problem in routine pathology practice is that most fetuses with the infection are macerated. This, in part, probably explains the paucity of published information on cardiac involvement. This study examined five cases of fatal hydrops fetalis with variable maceration with serologically proven parvovirus B19 infection. Transmission electron microscopy of cardiac tissue demonstrated intranuclear virions in both erythroid precursor cells and in cardiac myocytes in three of these cases. In each of these, immunogold electron microscopy provided confirmatory evidence of parvovirus infection. Virions were not identifiable where maceration had caused disintegration of nuclei in the myocytes. In addition, virions were absent in the three negative control cases where retroplacental hemorrhage was confirmed as the cause of death. This study suggests that parvovirus infection of cardiac myocytes may play a more important role in causing hydrops fetalis than previously realized. It also demonstrates that maceration should not discourage the use of electron microscopy.

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