Staphylococcus aureus bacteraemia associated with injected new psychoactive substances

2015 ◽  
Vol 144 (6) ◽  
pp. 1257-1266 ◽  
Author(s):  
D. J. GRIFFITH ◽  
C. L. MACKINTOSH ◽  
D. INVERARITY
Keyword(s):  
Staphylococcus Aureus ◽  
People Who Inject Drugs ◽  
Case Series ◽  
Injecting Drug Use ◽  
Significant Rise ◽  
New Psychoactive Substances ◽  
Psychoactive Substances ◽  
Unique Case ◽  
Pulmonary Lesions ◽  
Life Threatening

SUMMARYInjecting drug use is often associated with deep-seated infection. In Lothian in Scotland there has been a recent increase in the use of injected new psychoactive substances (NPS). Patients who have injected NPS have presented with Staphylococcus aureus bacteraemia (SAB) with life-threatening complications. We describe a unique case-series of 14 episodes of SAB in ten patients. Users of injected NPS had a significantly higher incidence of endocarditis and cavitating pulmonary lesions (P < 0·05) compared to those who inject only opiates. Cases of SAB in people who inject NPS have contributed to a significant rise in the overall incidence of SAB in people who inject drugs (P < 0·05) which has in turn impacted on the ability of Lothian to meet national targets for reducing the incidence of SAB.

Behavioral disorders and new psychoactive substances abuse, a French case series

2016 ◽  
Vol 33 (S1) ◽  
pp. S307-S307 ◽  
Author(s):  
M. Marillier ◽  
A. Batisse ◽  
C. Chevallier ◽  
S. Djezzar
Keyword(s):  
Psychiatric Disorder ◽  
Behavioral Disorders ◽  
Stab Wound ◽  
Case Series ◽  
New Psychoactive Substances ◽  
Psychoactive Substances ◽  
Sexual Practice ◽  
The Past ◽  
French Case ◽  
Competing Interest

IntroductionRange of drugs has largely increased the past few years, especially with the emergence of the New Psychoactive Substances (NPS) sold online. In front of serious risks they cause on human health, they are more and more regulated by the law.ObjectivesTo describe cases of extreme behavioral disorders and highlight risks of potential forensic complications linked to these consumptions.MethodsWe present a case series of serious auto or hetero-aggressive behavioral disorders related to NPS abuse and notified to the Parisian addictovigilance center.ResultsTwenty cases were identified between 2010 and 2015. Users were exclusively men, with mean age of 35.5 years (min: 20, max: 51). Synthetic cathinones are the predominant class of reported NPS (65%). An association between NPS and sexuality is found in 60% of cases (12); among them cathinones are used by 11 men. We observed 6 deaths among which, 5 were associated to sexual practice. Two cases of consumptions of cathinones induced torture and barbarian acts. Concerning aggressive behavioral disorders, we quote 3 cases of hetero-aggressivity (one by stab wound and 2 others developed an hypersexuality ± exhibitionism) and 9 cases of auto-aggressivity characterized by genital mutilations (1), defenestration (3), suicidal attempt (3), and acute psychiatric disorder with endangering life (2). Only four cases have been confirmed by toxicological analysis.ConclusionBehavioral disorders inducing forensics complications exist with NPS and particularly with cathinones. The problematic is certainly undervalued. A collaboration between addictovigilance and forensic services has to be improved.Disclosure of interestThe authors have not supplied their declaration of competing interest.

ANKYLOBLEPHARON FILIFORM ADNATUM AND ITS RARE ASSOCIATED SYNDROMES-A UNIQUE CASE SERIES

2021 ◽  
pp. 5-6
Author(s):  
S. Anandhalakshmi ◽  
Suhas Prabhakar ◽  
M. Radhakrishnan ◽  
V. Aisvarya ◽  
Anniksha.M. N
Keyword(s):  
Cleft Palate ◽  
Local Anesthesia ◽  
Multidisciplinary Approach ◽  
Surgical Intervention ◽  
Ectodermal Dysplasia ◽  
Case Series ◽  
Unique Case ◽  
Life Threatening ◽  
Ophthalmologic Examination ◽  
Early Surgical Intervention

This paper presents a case series of two neonates reporting with difculty in opening the eyes on the rst day of life. On ocular examination multiple adhesional bands are found between lids in both the eyes. On systemic evaluation a smooth philtrum, low set ears suggesting Edward's syndrome was revealed in baby A and baby B had posterior cleft palate, dermal erosions along with mandibular dysplasia revealing ectodermal dysplasia cleft palate syndrome. Transection under local anesthesia was done on both the babies. Examination post transection revealed normal eyelid function. Ankyloblepharon Filiform Adnatum (AFA) in a neonate should alert the ophthalmologist because it can be rarely associated with life threatening multi-systemic defects. This case series aims to highlight such rare presentations and exemplies the need for multidisciplinary approach. Early surgical intervention performed can reduce the risk of occlusion induced amblyopia and also helps in the detailed ophthalmologic examination later in life.

scholarly journals Case Series of Three Patients with Rifampicin-Induced Thrombocytopenia

2020 ◽  
Author(s):  
Chandramouli M.T
Keyword(s):  
Pulmonary Tuberculosis ◽  
Adverse Reactions ◽  
Rare Complication ◽  
Case Series ◽  
Tuberculosis Treatment ◽  
Effective Drug ◽  
Antitubercular Drugs ◽  
Short Course ◽  
Life Threatening

AbstractLife-threatening adverse reactions of antitubercular drugs are uncommon; however, thrombocytopenia is one such rare complication encountered with rifampicin, isoniazid, ethambutol, and pyrazinamide. Rifampicin is the most effective drug and its use in the tuberculosis treatment led to the emergence of modern and effective short-course regimens. I am reporting case series of three patients with pulmonary tuberculosis presented with rifampicin-induced thrombocytopenia.

scholarly journals Treatment and therapeutic strategies for pituitary apoplexy in pregnancy: a case series

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Yuya Kato ◽  
Yoshikazu Ogawa ◽  
Teiji Tominaga
Keyword(s):  
Pituitary Apoplexy ◽  
Clinical Symptoms ◽  
Case Series ◽  
Optimal Timing ◽  
Presenting Symptoms ◽  
Pathological Evaluation ◽  
Mother And Child ◽  
Life Threatening ◽  
In Pregnancy

Abstract Background Pregnancy is a known risk factor for pituitary apoplexy, which is life threatening for both mother and child. However, very few clinical interventions have been proposed for managing pituitary apoplexy in pregnancy. Case presentation We describe the management of three cases of pituitary apoplexy during pregnancy and review available literature. Presenting symptoms in our case series were headache and/or visual disturbances, and the etiology in all cases was hemorrhage. Conservative therapy was followed until 34 weeks of gestation, after which babies were delivered by cesarean section with prophylactic bolus hydrocortisone supplementation. Tumor removal was only electively performed after delivery using the transsphenoidal approach. All three patients and their babies had a good clinical course, and postoperative pathological evaluation revealed that all tumors were functional and that they secreted prolactin. Conclusions Although the mechanism of pituitary apoplexy occurrence remains unknown, the most important treatment strategy for pituitary apoplexy in pregnancy remains adequate hydrocortisone supplementation and frequent hormonal investigation. Radiological follow-up should be performed only if clinical symptoms deteriorate, and optimal timing for surgical resection should be discussed by a multidisciplinary team that includes obstetricians and neonatologists.

scholarly journals Macrophage Activation Syndrome in Adults: A Retrospective Case Series

2021 ◽  
Vol 9 ◽  
pp. 232470962110264
Author(s):  
Taylor Warmoth ◽  
Malvika Ramesh ◽  
Kenneth Iwuji ◽  
John S. Pixley
Keyword(s):  
Macrophage Activation Syndrome ◽  
Macrophage Activation ◽  
Pediatric Patients ◽  
Inflammatory Diseases ◽  
Systemic Juvenile Idiopathic Arthritis ◽  
Case Series ◽  
Adult Patients ◽  
Retrospective Case ◽  
Life Threatening ◽  
Activation Syndrome

Macrophage activation syndrome (MAS) is a form of hemophagocytic lymphohistocytosis that occurs in patients with a variety of inflammatory rheumatologic conditions. Traditionally, it is noted in pediatric patients with systemic juvenile idiopathic arthritis and systemic lupus erythematous. It is a rapidly progressive and life-threatening syndrome of excess immune activation with an estimated mortality rate of 40% in children. It has become clear recently that MAS occurs in adult patients with underlying rheumatic inflammatory diseases. In this article, we describe 6 adult patients with likely underlying MAS. This case series will outline factors related to diagnosis, pathophysiology, and review present therapeutic strategies.

Voltammetric profiling of new psychoactive substances: Piperazine derivatives

2021 ◽  
Vol 883 ◽  
pp. 115054
Author(s):  
D. Martins ◽  
E.M.P.J. Garrido ◽  
F. Borges ◽  
J.M.P.J. Garrido
Keyword(s):  
New Psychoactive Substances ◽  
Psychoactive Substances ◽  
Piperazine Derivatives

scholarly journals Autoimmune Hemolytic Anemia as a Complication of Congenital Anemias. A Case Series and Review of the Literature

2021 ◽  
Vol 10 (15) ◽  
pp. 3439
Author(s):  
Irene Motta ◽  
Juri Giannotta ◽  
Marta Ferraresi ◽  
Kordelia Barbullushi ◽  
Nicoletta Revelli ◽  
...  
Keyword(s):  
Hemolytic Anemia ◽  
Autoimmune Hemolytic Anemia ◽  
Case Series ◽  
Intravenous Immunoglobulins ◽  
Point Of View ◽  
First Line ◽  
Human Erythropoietin ◽  
Immune Mediated ◽  
Hemolytic Crisis ◽  
Life Threatening

Congenital anemias may be complicated by immune-mediated hemolytic crisis. Alloantibodies are usually seen in chronically transfused patients, and autoantibodies have also been described, although they are rarely associated with overt autoimmune hemolytic anemia (AIHA), a serious and potentially life-threatening complication. Given the lack of data on the AIHA diagnosis and management in congenital anemias, we retrospectively evaluated all clinically relevant AIHA cases occurring at a referral center for AIHA, hemoglobinopathies, and chronic hemolytic anemias, focusing on clinical management and outcome. In our cohort, AIHA had a prevalence of 1% (14/1410 patients). The majority were warm AIHA. Possible triggers were recent transfusion, infection, pregnancy, and surgery. All the patients received steroid therapy as the first line, and about 25% required further treatment, including rituximab, azathioprine, intravenous immunoglobulins, and cyclophosphamide. Transfusion support was required in 57% of the patients with non-transfusion-dependent anemia, and recombinant human erythropoietin was safely administered in one third of the patients. AIHA in congenital anemias may be challenging both from a diagnostic and a therapeutic point of view. A proper evaluation of hemolytic markers, bone marrow compensation, and assessment of the direct antiglobulin test is mandatory.

Sign in / Sign up

Export Citation Format

Share Document