The relationship between therapeutic injections and high 

prevalence of hepatitis C infection in Hafizabad, Pakistan

To determine the prevalence and routes of transmission of hepatitis C virus (HCV) infection in Hafizabad, Pakistan, we collected sera in 1993 from a geographically based random sample of residents, and in 1994 identified 15 HCV-infected individuals (cases) and 67 age and sex matched uninfected individuals (controls). Initially we approached 504 households, and collected serum from a randomly selected household member in 309 (64%). Twenty persons (6·5%) had anti-HCV antibody; 31% percent had hepatitis B core antibodies, and 4·3% had hepatitis B surface antigen. In the case-control study, persons who received more therapeutic injections (categorized as averaging 1, 2–4, 5–9 or >10 injections per year in the previous 10 years) were more likely to be infected with HCV (odds ratio 0, 1·5, 2·5 and 6·9 respectively, P=0·008) compared to persons averaging 0 injections per year. Efforts to limit therapeutic injections to only those that are medically indicated and that use sterile equipment are essential in order to prevent transmission of HCV.

Download Full-text

892 CLAUDIN-1 GENE VARIANTS AND SUSCEPTIBILITY TO HEPATITIS C INFECTION IN HIV-1 INFECTED INTRAVENOUS DRUG USERS (AN ANRS CASE-CONTROL STUDY)

Journal of Hepatology ◽

10.1016/s0168-8278(12)60904-0 ◽

2012 ◽

Vol 56 ◽

pp. S347

Author(s):

J. Ghosn ◽

O. Alibeu ◽

S. Sahali ◽

Y. Quertainmont ◽

L. Meyer ◽

...

Keyword(s):

Hepatitis C ◽

Drug Users ◽

Case Control Study ◽

Case Control ◽

Intravenous Drug ◽

Intravenous Drug Users ◽

Gene Variants ◽

Hepatitis C Infection ◽

Hiv 1 ◽

Control Study

Download Full-text

Low Positive Rates for HBeAg and HBV DNA in Rheumatoid Arthritis Patients—A Case-Control Study

10.21203/rs.3.rs-1204305/v1 ◽

2022 ◽

Author(s):

Yue Jia ◽

Jingjing Zhang ◽

Lingfei Mo ◽

Bomiao Ju ◽

Nan Hu ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Hepatitis B ◽

Case Control Study ◽

Hepatitis B Surface Antigen ◽

Case Control ◽

Hbv Dna ◽

Hbv Infection ◽

Infection Status ◽

And Gender ◽

Control Study

Abstract Background The rates of hepatitis B virus (HBV) infection in rheumatoid arthritis (RA) patients were controversial when considering the reported outcomes. It was speculated that HBV infection status altered after suffering from RA, and variations over HBV infection rates became apparent. Methods To compare the positive proportions of hepatitis B e antigen (HBeAg) and HBV DNA, a case-control study was performed between the 27 chronic hepatitis B (CHB) patients with RA and the 108 age-and gender-matched CHB patients. In addition, the positive rates of hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (anti-HBc) were surveyed among the 892 RA patients. Results Compared to the CHB patients, the CHB patients with RA exhibited lower rates of HBeAg positivity (11.1% vs. 35.2%, P = 0.003), HBV DNA positivity (37.0% vs. 63.9%, P = 0.007) and ALT elevation (11.1% vs. 35.2%, P = 0.024). In the 892 RA patients, the prevalence of HBsAg (3.0%) was lower than that of China national data (7.2%), whereas the anti-HBc positive rate of 44.6% was higher than that of 34.1%. Conclusion HBV infection status altered after suffering from RA. Compared to the matched CHB patients, low positive proportions of HBeAg and HBV DNA were observed for CHB patients with RA.

Download Full-text