scholarly journals A large case-control study on the predictability of hepatitis B surface antigen levels three years before hepatitis B surface antigen seroclearance

Hepatology ◽  
2012 ◽  
Vol 56 (3) ◽  
pp. 812-819 ◽  
Author(s):  
Wai-Kay Seto ◽  
Danny Ka-Ho Wong ◽  
James Fung ◽  
Ivan Fan-Ngai Hung ◽  
Daniel Yee-Tak Fong ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Surface Antigen ◽  
Case Control Study ◽  
Hepatitis B Surface Antigen ◽  
Case Control ◽  
Control Study ◽  
Large Case

scholarly journals Nested case-control study: hepatocellular carcinoma risk after hepatitis B surface antigen seroclearance

2016 ◽  
Vol 43 (11) ◽  
pp. 1197-1207 ◽  
Author(s):  
P. P. Gounder ◽  
L. R. Bulkow ◽  
M. Snowball ◽  
S. Negus ◽  
P. R. Spradling ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Case Control Study ◽  
Hepatitis B Surface Antigen ◽  
Case Control ◽  
Nested Case Control ◽  
Carcinoma Risk ◽  
Control Study

scholarly journals Association between Signal Transducer and Activator of Transcription 4 Genetic Polymorphisms and the Spontaneous Clearance of Hepatitis B Surface Antigen: A Large Population Case Control Study in China

2020 ◽  
Vol 1 (6) ◽  
pp. 256-262
Author(s):  
Xun Qi ◽  
Qirong Jiang ◽  
Ying Lv ◽  
Sisi Yang ◽  
Jing Li ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Surface Antigen ◽  
Case Control Study ◽  
Hepatitis B Surface Antigen ◽  
Case Control ◽  
Spontaneous Clearance ◽  
Large Sample Size ◽  
Signal Transducer ◽  
Hbsag Clearance ◽  
Control Study

Aim: Several host factors mediating immune response influence susceptibility to Hepatitis B Virus (HBV) infection, ability to clear the virus, and maintenance of a chronic state. Signal Transducer and Activator of Transcription 4 (STAT4) variations are correlated with the risk of developing autoimmune diseases. However, there have been few studies to assess the relationship between STAT4 variations and Hepatitis B surface Antigen (HBsAg) clearance in adults infected with HBV. Our aim was to evaluate the association between genetic variants in STAT4 and HBsAg clearance in a large sample size population. Methods: This case control study included Chronic Hepatitis B (CHB) (n = 1.688), HBsAg Clearance after Treatment (TC) (n = 170), HBV Uninfected (HC) (n = 1.012), and HBsAg Spontaneous Clearance (SC) (n = 1,052) patients. In the CHB group, patients were categorized into four subgroups: the Immune Tolerant (IT), Immune Active (IA), Inactive (IC), and Immune Reactivation (IR) phases, with 97, 855, 198, and 538 patients in each subgroup, respectively. Results: We found that the G allele in STAT4 rs7574865 was more frequent in the CHB and TC groups, compared with the SC group, whereas the STAT4 rs7574865 GG genotype was more frequent in the CHB and TC group, compared with the SC group in the dominant model. However, there was no statistical significance in genotype between TC and CHB, nor between the IT, IA, IC, and IR groups. Conclusions: The prevalence of the minor allele rs7574865 T was higher in subjects with spontaneously cleared HBV infections than in CHB patients.

Inverse relationship between hepatic steatosis and hepatitis B viremia: Results of a large case-control study

2017 ◽  
Vol 25 (1) ◽  
pp. 97-104 ◽  
Author(s):  
R. W. H. Hui ◽  
W.-K. Seto ◽  
K.-S. Cheung ◽  
L.-Y. Mak ◽  
K. S. H. Liu ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Hepatic Steatosis ◽  
Inverse Relationship ◽  
Case Control Study ◽  
Case Control ◽  
Control Study ◽  
Large Case

scholarly journals Low Positive Rates for HBeAg and HBV DNA in Rheumatoid Arthritis Patients—A Case-Control Study

2022 ◽  
Author(s):  
Yue Jia ◽  
Jingjing Zhang ◽  
Lingfei Mo ◽  
Bomiao Ju ◽  
Nan Hu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Hepatitis B ◽  
Case Control Study ◽  
Hepatitis B Surface Antigen ◽  
Case Control ◽  
Hbv Dna ◽  
Hbv Infection ◽  
Infection Status ◽  
And Gender ◽  
Control Study

Abstract Background The rates of hepatitis B virus (HBV) infection in rheumatoid arthritis (RA) patients were controversial when considering the reported outcomes. It was speculated that HBV infection status altered after suffering from RA, and variations over HBV infection rates became apparent. Methods To compare the positive proportions of hepatitis B e antigen (HBeAg) and HBV DNA, a case-control study was performed between the 27 chronic hepatitis B (CHB) patients with RA and the 108 age-and gender-matched CHB patients. In addition, the positive rates of hepatitis B surface antigen (HBsAg) and hepatitis B core antibody (anti-HBc) were surveyed among the 892 RA patients. Results Compared to the CHB patients, the CHB patients with RA exhibited lower rates of HBeAg positivity (11.1% vs. 35.2%, P = 0.003), HBV DNA positivity (37.0% vs. 63.9%, P = 0.007) and ALT elevation (11.1% vs. 35.2%, P = 0.024). In the 892 RA patients, the prevalence of HBsAg (3.0%) was lower than that of China national data (7.2%), whereas the anti-HBc positive rate of 44.6% was higher than that of 34.1%. Conclusion HBV infection status altered after suffering from RA. Compared to the matched CHB patients, low positive proportions of HBeAg and HBV DNA were observed for CHB patients with RA.

scholarly journals The relationship between therapeutic injections and high prevalence of hepatitis C infection in Hafizabad, Pakistan

1997 ◽  
Vol 119 (3) ◽  
pp. 349-356 ◽  
Author(s):  
S. P. LUBY ◽  
K. QAMRUDDIN ◽  
A. A. SHAH ◽  
A. OMAIR ◽  
O. PAHSA ◽  
...  
Keyword(s):  
Hepatitis C ◽  
Hepatitis B ◽  
Case Control Study ◽  
Hepatitis B Surface Antigen ◽  
Case Control ◽  
Hepatitis C Infection ◽  
High Prevalence ◽  
Hcv Antibody ◽  
The Relationship ◽  
Control Study

To determine the prevalence and routes of transmission of hepatitis C virus (HCV) infection in Hafizabad, Pakistan, we collected sera in 1993 from a geographically based random sample of residents, and in 1994 identified 15 HCV-infected individuals (cases) and 67 age and sex matched uninfected individuals (controls). Initially we approached 504 households, and collected serum from a randomly selected household member in 309 (64%). Twenty persons (6·5%) had anti-HCV antibody; 31% percent had hepatitis B core antibodies, and 4·3% had hepatitis B surface antigen. In the case-control study, persons who received more therapeutic injections (categorized as averaging 1, 2–4, 5–9 or >10 injections per year in the previous 10 years) were more likely to be infected with HCV (odds ratio 0, 1·5, 2·5 and 6·9 respectively, P=0·008) compared to persons averaging 0 injections per year. Efforts to limit therapeutic injections to only those that are medically indicated and that use sterile equipment are essential in order to prevent transmission of HCV.

scholarly journals Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma: a matched nested case–control study

2008 ◽  
Vol 89 (11) ◽  
pp. 2882-2890 ◽  
Author(s):  
Zhong-Liao Fang ◽  
Caroline A. Sabin ◽  
Bai-Qing Dong ◽  
Shao-Chao Wei ◽  
Qin-Yan Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Factor ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Case Control Study ◽  
Case Control ◽  
Deletion Mutations ◽  
B Virus ◽  
Nested Case Control ◽  
Control Study

A matched nested case–control study of 33 paired cases and controls was conducted, based on a study cohort in Long An county, Guangxi, China, to determine whether infection with hepatitis B virus (HBV) with pre-S deletions is independently associated with the development of hepatocellular carcinoma (HCC), without the confounding effects of basal core promoter (BCP) double mutations. The prevalence of pre-S deletions was significantly higher in HCC (45.5 %, 15 of 33) than the controls (18.2 %, 6 of 33) (P<0.01), under the control of the influence of BCP double mutations. Most of the pre-S deletions occurred in, or involved, the 5′ half of the pre-S2 region and the difference between HCC (93.3 %, 14 of 15) and controls (66.7 %, four of six) was significant for this region (P=0.015). There was no significant difference in pre-S deletions between the BCP mutant group and BCP wild-type group (P>0.05), nor was the prevalence of pre-S deletions significantly different between genotypes B and C (P>0.1). These results suggest that pre-S deletions constitute an independent risk factor for HCC and their emergence and effect are independent of BCP mutations. The 5′ terminus of pre-S2 is the favoured site for the deletion mutations, especially in HCC cases. Further prospective studies are required to confirm the role of these mutations in the development of HCC.

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