scholarly journals Multimodal assessment of sustained threat in adolescents with nonsuicidal self-injury

2021 ◽  
pp. 1-19
Author(s):  
Zeynep Başgöze ◽  
Salahudeen A. Mirza ◽  
Thanharat Silamongkol ◽  
Dawson Hill ◽  
Conner Falke ◽  
...  
Keyword(s):  
Suicide Attempt ◽  
Social Stress ◽  
Stress Test ◽  
Trier Social Stress Test ◽  
Resting State Functional Connectivity ◽  
Cross Sectional ◽  
Amygdala Activation ◽  
Self Injury ◽  
Cross Sectional Design ◽  
Nonsuicidal Self Injury

Abstract Nonsuicidal self-injury (NSSI) is a common but poorly understood phenomenon in adolescents. This study examined the Sustained Threat domain in female adolescents with a continuum of NSSI severity (N = 142). Across NSSI lifetime frequency and NSSI severity groups (No + Mild NSSI, Moderate NSSI, Severe NSSI), we examined physiological, self-reported and observed stress during the Trier Social Stress Test; amygdala volume; amygdala responses to threat stimuli; and resting-state functional connectivity (RSFC) between amygdala and medial prefrontal cortex (mPFC). Severe NSSI showed a blunted pattern of cortisol response, despite elevated reported and observed stress during TSST. Severe NSSI showed lower amygdala–mPFC RSFC; follow-up analyses suggested that this was more pronounced in those with a history of suicide attempt for both moderate and severe NSSI. Moderate NSSI showed elevated right amygdala activation to threat; multiple regressions showed that, when considered together with low amygdala–mPFC RSFC, higher right but lower left amygdala activation predicted NSSI severity. Patterns of interrelationships among Sustained Threat measures varied substantially across NSSI severity groups, and further by suicide attempt history. Study limitations include the cross-sectional design, missing data, and sampling biases. Our findings highlight the value of multilevel approaches in understanding the complexity of neurobiological mechanisms in adolescent NSSI.

scholarly journals Disrupted upregulation of salience network connectivity during acute stress in siblings of schizophrenia patients

2020 ◽  
pp. 1-11
Author(s):  
Judith M. C. van Leeuwen ◽  
Christiaan H. Vinkers ◽  
Matthijs Vink ◽  
René S. Kahn ◽  
Marian Joëls ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Social Stress ◽  
Dynamic Range ◽  
Acute Stress ◽  
Temporal Dynamics ◽  
Stress Test ◽  
Trier Social Stress Test ◽  
Salience Network ◽  
Healthy Controls ◽  
Resting State Functional Connectivity

Abstract Background An adaptive neural stress response is essential to adequately cope with a changing environment. It was previously argued that sympathetic/noradrenergic activity during acute stress increases salience network (SN) connectivity and reduces executive control network (ECN) connectivity in healthy controls, with opposing effects in the late aftermath of stress. Altered temporal dynamics of these networks in response to stress are thought to play a role in the development of psychopathology in vulnerable individuals. Methods We exposed male healthy controls (n = 40, mean age = 33.9) and unaffected siblings of schizophrenia patients (n = 39, mean age = 33.2) to the stress or control condition of the trier social stress test and subsequently investigated resting state functional connectivity of the SN and ECN directly after and 1.5 h after stress. Results Acute stress resulted in increased functional connectivity within the SN in healthy controls, but not in siblings (group × stress interaction pfwe < 0.05). In the late aftermath of stress, stress reduced functional connectivity within the SN in both groups. Moreover, we found increased functional connectivity between the ECN and the cerebellum in the aftermath of stress in both healthy controls and siblings of schizophrenia patients. Conclusions The results show profound differences between siblings of schizophrenia patients and controls during acute stress. Siblings lacked the upregulation of neural resources necessary to quickly and adequately cope with a stressor. This points to a reduced dynamic range in the sympathetic response, and may constitute a vulnerability factor for the development of psychopathology in this at-risk group.

scholarly journals Prevalence of nonsuicidal Self-injury and Suicide Attempt among Young Adult university Students

2018 ◽  
Vol 52 (1) ◽  
Author(s):  
Jhun Robbie U. Galicia ◽  
Tomas D. Bautista
Keyword(s):  
Young Adult ◽  
Suicide Attempt ◽  
University Students ◽  
Suicide Attempts ◽  
Suicidal Attempt ◽  
Preventive Program ◽  
Cross Sectional ◽  
Self Injury ◽  
Self Harm ◽  
Nonsuicidal Self Injury

Objective. To determine the prevalence and possible risk factors associated with nonsuicidal self-injury (NSSI) and suicide attempt among young adult university students. Methods. A cross-sectional study involving six colleges from a university in Manila, from which randomization through a computer-generated random number was done. Data were obtained through self-administered questionnaires. Descriptive analysis and logistic regression were done to evaluate the data. Results. A total of 225 students participated in the study (mean age of 20.33 years). Majority were females (60.44%). Ideations of self-harm were reported in 49.33%. NSSI and suicide attempts were reported at 26.22% and 14.67%, respectively. In general, self-harm (NSSI and/or suicidal attempt) was reported at 33.78%, while 7.11% of the respondents reported both NSSI and suicidal attempt in the past. Furthermore, 2-3 out of 10 students who engaged in NSSI would have a suicide attempt. Associated factors of NSSI and suicide attempt were age, female gender, gender orientation, parental civil status, employment, economic standing, and psychopathology which support the findings cited in literature. Conclusion. The high prevalence of self-harm NSSI and/or suicidal attempt (33.78%) and the finding that NSSI was a gateway for suicidal attempt and that 2-3 out of ten who engaged in NSSI would have a suicide attempt underscores the need to develop an early intervention upon detecting self-harming behaviors and a preventive program for the progression of NSSI to suicide attempts.

scholarly journals Nonsuicidal self-injury thoughts and behavioural characteristics: Associations with suicidal thoughts and behaviours among community adolescents

2020 ◽  
Author(s):  
Kealagh Robinson ◽  
Jessica A. Garisch ◽  
Marc Wilson
Keyword(s):  
Suicide Attempt ◽  
Sensation Seeking ◽  
Characteristic Analysis ◽  
Suicidal Thoughts ◽  
Cross Sectional ◽  
Lifetime History ◽  
Self Injury ◽  
Behavioural Characteristics ◽  
History Of ◽  
Nonsuicidal Self Injury

Background: We consider whether nonsuicidal self-injury (NSSI) thoughts – in the absence of any NSSI behaviour – are associated with suicidal thoughts and behaviours among adolescents, before examining whether characteristics of NSSI behaviour are associated with greater suicidal thoughts and behaviours. Methods: Adolescents (n = 2,057, M age =15.56) recruited from secondary schools reported their lifetime history of NSSI, suicidal thoughts and behaviours, NSSI characteristics, and NSSI functions. Receiver Operating Characteristic analysis test whether NSSI status and characteristics of NSSI behaviour are diagnostic of clinically elevated suicidal thoughts and behaviours (a score of 7 or higher on the Suicide Behaviours Questionnaire-Revised). Regression models test whether NSSI functions predict greater suicidality. Results: Adolescents with NSSI thoughts and those with NSSI behaviour were more likely to report lifetime suicidal ideation and past-year suicide plan(s) than adolescents with no history of NSSI. In addition, adolescents with a history of NSSI were more likely to report a lifetime history of suicide attempt(s) as well as past-year suicide attempt(s) than adolescents with no history of NSSI. A greater number of NSSI methods, requiring medical assistance for NSSI injuries, and engaging in NSSI for self-punishment, anti-suicide, and sensation-seeking functions were associated with greater severity of suicidal thoughts and behaviours.Limitations: Data are cross-sectional, limiting inferences about causality.Conclusions: Findings emphasize the importance of NSSI thoughts and characteristics of NSSI behaviour in understanding the complex relationship between NSSI and suicidal thoughts and behaviours among adolescents.

Messung der Stimmfrequenz im Paargespräch – Chancen für Diagnostik und Intervention in der Paartherapie

2020 ◽  
Vol 68 (4) ◽  
pp. 217-227 ◽  
Author(s):  
Lisanne J. Bulling ◽  
Isabella C. Bertschi ◽  
Céline C. Stadelmann ◽  
Tina Niederer ◽  
Guy Bodenmann
Keyword(s):  
Social Stress ◽  
Stress Test ◽  
Trier Social Stress Test

Zusammenfassung. Die vorliegende Arbeit stellt die bisherigen empirischen Befunde zur Sprachgrundfrequenz (f0) in Paargesprächen vor und untersucht, wie sich die f0 nach einer experimentellen Stressinduktion im anschließenden spontanen Gespräch zwischen den Partner_innen verändert, wie die f0 mit der verbalen Stressäußerung zusammenhängt und wie sie zwischen den beiden Partner_innen kovariiert. Von 128 heterosexuellen Paaren nahm jeweils eine Person pro Paar am Trier Social Stress Test (TSST) teil. Die dem TSST vorangehende und anschließende naturalistische Interaktion zwischen den Partner_innen wurde gefilmt und nach Gesprächsthema und Art der Stressäußerung kodiert. Wie vorherige Studien zur f0 im Paargespräch zeigte auch die vorliegende Studie, dass die f0 wichtige Informationen über die Partnerschaft enthält. Während eine Erhöhung der f0 in Gesprächen über einen paarinternen Stressor (d.h. bei Konfliktgesprächen) mit negativen Kommunikationsmustern einherging, zeigte die vorliegende Studie, dass die f0 bei Gesprächen über einen paarexternen Stressor (d.h. beim TSST) mit emotionsorientierten Stressäußerungen einherging, also einer für den Stressbewältigungsprozess förderlichen Art der Kommunikation. Die Oszillatorenmodelle zeigen darüber hinaus, dass eine Kopplung der f0 zwischen den Partner_innen besteht, was darauf hindeutet, dass die nicht gestressten Partner_innen auf die paraverbalen Stressäußerungen der gestressten Partner_innen mit ihren eigenen paraverbalen Stressäußerungen reagieren.

Immunoassay or LC-MS/MS for the measurement of salivary cortisol in children?

2016 ◽  
Vol 54 (5) ◽  
Author(s):  
Yoon Ju Bae ◽  
Alexander Gaudl ◽  
Sonia Jaeger ◽  
Stephanie Stadelmann ◽  
Andreas Hiemisch ◽  
...  
Keyword(s):  
Salivary Cortisol ◽  
Social Stress ◽  
Statistical Power ◽  
Stress Test ◽  
Externalizing Disorders ◽  
Cross Reactivity ◽  
Trier Social Stress Test ◽  
Healthy Children ◽  
Kinetic Assay ◽  
The Difference

AbstractBackground:Dysregulation of the adrenal cortex has been assessed with measurement of salivary cortisol. So far salivary cortisol is routinely measured with immunoassay (IA). However, liquid chromatography-tandem mass spectrometry (MS) is known to offer better specificity. We compared the concentrations of salivary cortisol measured by MS and IA at basal and stress induced conditions and evaluated reasons for the difference in method-dependent cortisol results.Methods:Saliva samples (n=2703) were collected from 169 children (age range: 8–14 years; 81 healthy children; 55 with internalizing and 33 with externalizing disorders) under circadian conditions and during the Trier Social Stress Test for Children (TSST-C). Biochemical analyses were performed with MS for cortisol and cortisone, IA (IBL, RE62011) for cortisol, and enzyme kinetic assay for α-amylase.Results:MS and IA showed mostly comparable results for circadian activity and TSST-C response with similar statistical power. However, IA measured cortisol concentrations about 2.39-fold higher than MS. We found that this difference in measured values between MS and IA was mainly due to different standardization of IA compared to MS. In addition, at cortisol IA concentration below 5 nmol/L, cross-reactivity with cortisone was found to contribute to the lower concordance between MS and IA.Conclusions:Immunoassay and LC-MS/MS were largely comparable in the interpretation of salivary cortisol dynamics in stress research. But the IA method revealed a restricted accuracy in the measuring range below 5 nmol/L.

Psychological, Structural, Social and Economic Determinants of Suicide Attempt: Risk Assessment and Decision Making Strategies

2021 ◽  
pp. 003022282110034
Author(s):  
Azam Farmani ◽  
Mojtaba Rahimianbougar ◽  
Yousef Mohammadi ◽  
Hossein Faramarzi ◽  
Siamak Khodarahimi ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Suicide Attempt ◽  
Suicide Attempts ◽  
Psychological Services ◽  
Cross Sectional ◽  
Economic Determinants ◽  
History Of ◽  
Cross Sectional Design ◽  
High Level ◽  
Risk Assessment And Management

The aim of this research was to conduct a risk assessment and management of psychological, structural, social and economic determinants (PSSED) in a suicide attempt. The sample consisted of 353 individuals who had a recorded history of suicidal attempt; and 20 professional individuals by purposive sampling method within a descriptive cross-sectional design. Worksheets for RAM and AHP were used for data collection in this study. The rate of suicide attempt was 7.21 per 100,000 population in this study. Analysis showed that depression and mental disorders; personality disorders; family problems; socio-cultural and economic problems; lack of awareness; and low level of education have a high level of risk for suicide attempts. Psychiatric and psychological services; awareness and knowledge of life skills; medical services to dysfunctional families; development of community-based planning for PSSED of suicide; and employment and entrepreneurship services may lower suicide attempt risk.

scholarly journals Childhood Adversities and Salivary Cortisol Responses to the Trier Social Stress Test: A Systematic Review of Studies Using the Children Trauma Questionnaire (CTQ)

2020 ◽  
Vol 18 (1) ◽  
pp. 29
Author(s):  
Chuk Ling Julian Lai ◽  
Daryl Yu Heng Lee ◽  
Monique On Yee Leung
Keyword(s):  
Salivary Cortisol ◽  
Social Stress ◽  
Stress Test ◽  
Trier Social Stress Test ◽  
Future Research ◽  
Cortisol Response ◽  
Childhood Adversities ◽  
Social Stressors ◽  
Childhood Trauma Questionnaire ◽  
Cortisol Responses

Alteration in cortisol response to acute social stressors has been hypothesized to mediate childhood adversities (CA) and increased morbidity in adulthood. However, the evidence supporting an association between CA and cortisol response to social stressors is inconclusive. The present review addressed this issue by reviewing the literature on CA and cortisol response to acute social stressors, with a focus on studies with adolescents or adults, using the Childhood Trauma Questionnaire (CTQ) to assess CA, and examining salivary cortisol response to the Trier Social Stress Test (TSST). Systematic searches of relevant articles in PsycINFO, PubMed, Web of Science and ScienceDirect in February and March 2020 identified 12 articles including 1196 participants with mean ages ranging from 15.3 to 52.3 yrs. across studies. CTQ scores were significantly associated with cortisol response in 2 studies. In addition, the physical abuse and emotional neglect subscales were associated with cortisol response respectively in 2 separate studies. The lack of association between CA and cortisol response calls for more longitudinal studies, and the use of formal records of maltreatment or informant reports in future research to complement information collected by retrospective measures. In addition, increased attention to biological mechanisms other than that associated with the regulation of cortisol in explaining the connection between CA and psychiatry morbidity is warranted.

A Virtual Reality Version of the Trier Social Stress Test: A Pilot Study

2011 ◽  
Vol 20 (4) ◽  
pp. 325-336 ◽  
Author(s):  
Mattias Wallergård ◽  
Peter Jönsson ◽  
Gerd Johansson ◽  
Björn Karlson
Keyword(s):  
Virtual Reality ◽  
Stress Response ◽  
Pilot Study ◽  
Social Stress ◽  
Stress Test ◽  
Structured Interview ◽  
Trier Social Stress Test ◽  
Physiological Data ◽  
Virtual Humans ◽  
Arithmetic Task

One of the most common methods of inducing stress in the laboratory in order to examine the stress response in healthy and clinical populations is the Trier Social Stress Test (TSST). Briefly, the participant is asked to deliver a speech and to perform an arithmetic task in front of an evaluating committee. The committee, consisting of three trained actors, does not respond emotionally during the test, which makes the situation very stressful for the participant. One disadvantage of the TSST is that it can be difficult to hold the experimental conditions constant. In particular, it may be difficult for actors to hold their acting constant across all sessions. Furthermore, there are several practical problems and costs associated with hiring professional actors. A computerized version of the TSST using virtual humans could be a way to avoid these problems provided that it is able to induce a stress response similar to the one of the original TSST. The purpose of the present pilot study was therefore to investigate the stress response to a virtual reality (VR) version of the TSST visualized using an immersive VR system (VR-TSST). Seven healthy males with an average age of 24 years (range: 23–26 years) performed the VR-TSST. This included delivering a speech and performing an arithmetic task in front of an evaluating committee consisting of three virtual humans. The VR equipment was a CAVE equipped with stereoscopy and head tracking. ECG and respiration were recorded as well as the participant's behavior and comments. Afterward, a semi-structured interview was carried out. In general, the subjective and physiological data from the experiment indicated that the VR version of the TSST induced a stress response in the seven participants. In particular, the peak increase in heart rate was close to rates observed in studies using the traditional TSST with real actors. These results suggest that virtual humans visualized with an immersive VR system can be used to induce stress under laboratory conditions.

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