TOP CITED PAPERS IN INTERNATIONAL PSYCHOGERIATRICS: 6b. BEHAVIORAL DISORDERS AND CAREGIVERS' REACTION IN TAIWANESE PATIENTS WITH ALZHEIMER'S DISEASE

The behavioral and psychological symptoms of dementia (BPSD) are common and serious problems that affect the quality of life of the patients who experience such symptoms as well as their caregivers (Matsui et al., 2006). BPSD present a major challenge in the medical management of cognitively impaired patients. Our paper entitled “Behavioral disorders and caregivers’ reaction in Taiwanese patients with Alzheimer's disease” (hereafter referred to as the “paper”) (Fuh et al., 2001) has been cited widely, reflecting the importance of these clinical issues and the growing international interest in studies of BPSD.

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Do Hearing Aids Influence Behavioral and Psychological Symptoms of Dementia and Quality of Life in Hearing Impaired Alzheimer’s Disease Patients and Their Caregivers?

Journal of Alzheimer s Disease ◽

10.3233/jad-160792 ◽

2017 ◽

Vol 58 (1) ◽

pp. 109-121 ◽

Cited By ~ 17

Author(s):

Arnaud Adrait ◽

Xavier Perrot ◽

Marie-France Nguyen ◽

Marine Gueugnon ◽

Charles Petitot ◽

...

Keyword(s):

Quality Of Life ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Hearing Aids ◽

Psychological Symptoms ◽

Hearing Impaired ◽

Behavioral And Psychological Symptoms

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Behavioral and Neuropsychiatric Outcomes in Alzheimer's Disease

CNS Spectrums ◽

10.1017/s1092852900014206 ◽

2005 ◽

Vol 10 (S18) ◽

pp. 22-25 ◽

Cited By ~ 16

Author(s):

Jeffrey L. Cummings

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cholinesterase Inhibitors ◽

Psychological Symptoms ◽

Neuropsychiatric Symptoms ◽

Caregiver Distress ◽

Aspartate Receptor ◽

Home Placement ◽

Behavioral And Psychological Symptoms

AbstractBehavioral and psychological symptoms of dementia pose significant challenges in the management of patients with Alzheimer's disease. Neuropsychiatric symptoms are associated with cognitive decline, highly impaired activities of daily living, and frontal lobe pathology. Moreover, behavioral and psychological symptoms can diminish patient quality of life, increase caregiver distress, and accelerate nursing home placement. Although these symptoms are often associated with the later stages of Alzheimer's disease, a high percentage of individuals with mild cognitive impairment or mild Alzheimer's report symptoms as well. This article provides an overview of behavioral and neuropsychiatric symptoms associated with Alzheimer's disease and discusses nonpharmacologic and pharmacologic approaches to the management of such symptoms. For patients with severe behavioral and psychological symptoms of dementia, pychotropic agents may be warranted, whereas approved therapies for Alzheimer's, including cholinesterase inhibitors and the N-methyl-D-aspartate receptor antagonist memantine, may be appropriate in less severe cases.

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A Comparison of Behavioral and Psychological Symptoms of Dementia (BPSD) and BPSD Sub-Syndromes in Early-Onset and Late-Onset Alzheimer’s Disease

Journal of Alzheimer s Disease ◽

10.3233/jad-215061 ◽

2021 ◽

pp. 1-9

Author(s):

Natalia Altomari ◽

Francesco Bruno ◽

Valentina Laganà ◽

Nicoletta Smirne ◽

Rosanna Colao ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Early Onset ◽

Psychological Symptoms ◽

Late Onset ◽

Point Of View ◽

Behavioral And Psychological Symptoms ◽

Over Time

Background: Behavioral and psychological symptoms of dementia (BPSD) have a large impact on the quality of life of patients with Alzheimer’s disease (AD). Few studies have compared BPSD between early-onset (EOAD) and late-onset (LOAD) patients, finding conflicting results. Objective: The aims of this study were to: 1) characterize the presence, overall prevalence, and time of occurrence of BPSD in EOAD versus LOAD; 2) estimate the prevalence over time and severity of each BPSD in EOAD versus LOAD in three stages: pre-T0 (before the onset of the disease), T0 (from onset to 5 years), and T1 (from 5 years onwards); 3) track the manifestation of BPSD sub-syndromes (i.e., hyperactivity, psychosis, affective, and apathy) in EOAD versus LOAD at T0 and T1. Methods: The sample includes 1,538 LOAD and 387 EOAD diagnosed from 1996 to 2018. Comprehensive assessment batteries, including the Neuropsychiatric Inventory (NPI), were administered at the first medical assessment and at different follow-up period. Results: The overall prevalence for the most of BPSD was significantly higher in EOAD compared to LOAD whereas most BPSD appeared significantly later in EOAD patients. Between the two groups, from pre-T0 to T1 we recorded a different pattern of BPSD prevalence over time as well as for BPSD sub-syndromes at T0 and T1. Results on severity of BPSD did not show significant differences. Conclusion: EOAD and LOAD represent two different forms of a single entity not only from a neuropathological, cognitive, and functional level but also from a psychiatric point of view.

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