Motor and visuomotor function in 10-year-old children with congenital heart disease: association with behaviour

2021 ◽  
pp. 1-6
Author(s):  
Joana Teixeira ◽  
Jon Caflisch ◽  
Aziz Chaouch ◽  
Ingrid Beck ◽  
Maria Feldmann ◽  
...  
Keyword(s):  
Motor Function ◽  
Motor Performance ◽  
Motor Coordination ◽  
Behavioural Problems ◽  
Normative Values ◽  
Motor Score ◽  
Visuomotor Integration ◽  
Increased Risk ◽  
Motor Problems ◽  
Zurich Neuromotor Assessment

Abstract Background: Children with CHD are at increased risk for neurodevelopmental impairments. There is little information on long-term motor function and its association with behaviour. Aims: To assess motor function and behaviour in a cohort of 10-year-old children with CHD after cardiopulmonary bypass surgery. Methods: Motor performance and movement quality were examined in 129 children with CHD using the Zurich Neuromotor Assessment providing four timed and one qualitative component, and a total timed motor score was created based on the four timed components. The Beery Test of Visual–Motor Integration and the Strengths and Difficulties Questionnaire were administered. Results: All Zurich Neuromotor Assessment motor tasks were below normative values (all p ≤ 0.001), and the prevalence of poor motor performance (≤10th percentile) ranged from 22.2% to 61.3% in the different components. Visuomotor integration and motor coordination were poorer compared to norms (all p ≤ 0.001). 14% of all analysed children had motor therapy at the age of 10 years. Children with a total motor score ≤10th percentile showed more internalising (p = 0.002) and externalising (p = 0.028) behavioural problems. Conclusions: School-aged children with CHD show impairments in a variety of motor domains which are related to behavioural problems. Our findings emphasise that motor problems can persist into school-age and require detailed assessment and support.

Development of the corticospinal system and hand motor function: central conduction times and motor performance tests

2000 ◽  
Vol 42 (4) ◽  
pp. 220-227 ◽  
Author(s):  
U M Fietzek ◽  
F Heinen ◽  
S Berweck ◽  
S Maute ◽  
A Hufschmidt ◽  
...  
Keyword(s):  
Motor Function ◽  
Motor Performance ◽  
Performance Tests ◽  
Corticospinal System

scholarly journals Cultural bias in motor function patterns: Potential relevance for predictive, preventive, and personalized medicine

2021 ◽  
Author(s):  
Karen Otte ◽  
Tobias Ellermeyer ◽  
Masahide Suzuki ◽  
Hanna M. Röhling ◽  
Ryota Kuroiwa ◽  
...  
Keyword(s):  
Personalized Medicine ◽  
Motor Function ◽  
Motor Performance ◽  
Body Height ◽  
Healthy Adults ◽  
Cultural Bias ◽  
Full Potential ◽  
Japanese Adults ◽  
Body Stature ◽  
Motion Assessment

Abstract Background Quantification of motor performance has a promising role in personalized medicine by diagnosing and monitoring, e.g. neurodegenerative diseases or health problems related to aging. New motion assessment technologies can evolve into patient-centered eHealth applications on a global scale to support personalized healthcare as well as treatment of disease. However, uncertainty remains on the limits of generalizability of such data, which is relevant specifically for preventive or predictive applications, using normative datasets to screen for incipient disease manifestations or indicators of individual risks. Objective This study explored differences between healthy German and Japanese adults in the performance of a short set of six motor tests. Methods Six motor tasks related to gait and balance were recorded with a validated 3D camera system. Twenty-five healthy adults from Chiba, Japan, participated in this study and were matched for age, sex, and BMI to a sample of 25 healthy adults from Berlin, Germany. Recordings used the same technical setup and standard instructions and were supervised by the same experienced operator. Differences in motor performance were analyzed using multiple linear regressions models, adjusted for differences in body stature. Results From 23 presented parameters, five showed group-related differences after adjustment for height and weight (R2 between .19 and .46, p<.05). Japanese adults transitioned faster between sitting and standing and used a smaller range of hand motion. In stepping-in-place, cadence was similar in both groups, but Japanese adults showed higher knee movement amplitudes. Body height was identified as relevant confounder (standardized beta >.5) for performance of short comfortable and maximum speed walks. For results of posturography, regression models did not reveal effects of group or body stature. Conclusions Our results support the existence of a population-specific bias in motor function patterns in young healthy adults. This needs to be considered when motor function is assessed and used for clinical decisions, especially for personalized predictive and preventive medical purposes. The bias affected only the performance of specific items and parameters and is not fully explained by population-specific ethnic differences in body stature. It may be partially explained as cultural bias related to motor habits. Observed effects were small but are expected to be larger in a non-controlled cross-cultural application of motion assessment technologies with relevance for related algorithms that are being developed and used for data processing. In sum, the interpretation of individual data should be related to appropriate population-specific or even better personalized normative values to yield its full potential and avoid misinterpretation.

scholarly journals Cerebellar Dysfunction in Adults with Prader Willi Syndrome

2021 ◽  
Vol 10 (15) ◽  
pp. 3320
Author(s):  
Laura Blanco-Hinojo ◽  
Laia Casamitjana ◽  
Jesus Pujol ◽  
Gerard Martínez-Vilavella ◽  
Susanna Esteba-Castillo ◽  
...  
Keyword(s):  
Motor Control ◽  
Motor Function ◽  
Motor Coordination ◽  
Task Demands ◽  
Functional Mobility ◽  
Prader Willi Syndrome ◽  
Pathophysiological Mechanism ◽  
Motor Tasks ◽  
Correlation Pattern ◽  
Motor Processing

Severe hypotonia during infancy is a hallmark feature of Prader Willi syndrome (PWS). Despite its transient expression, moto development is delayed and deficiencies in motor coordination are present at older ages, with no clear pathophysiological mechanism yet identified. The diverse motor coordination symptoms present in adult PWS patients could be, in part, the result of a common alteration(s) in basic motor control systems. We aimed to examine the motor system in PWS using functional MRI (fMRI) during motor challenge. Twenty-three adults with PWS and 22 matched healthy subjects participated in the study. fMRI testing involved three hand motor tasks of different complexity. Additional behavioral measurements of motor function were obtained by evaluating hand grip strength, functional mobility, and balance. Whole brain activation maps were compared between groups and correlated with behavioral measurements. Performance of the motor tasks in PWS engaged the neural elements typically involved in motor processing. While our data showed no group differences in the simplest task, increasing task demands evoked significantly weaker activation in patients in the cerebellum. Significant interaction between group and correlation pattern with measures of motor function were also observed. Our study provides novel insights into the neural substrates of motor control in PWS by demonstrating reduced cerebellar activation during movement coordination.

The Relationship between Aquatic Independence and Gross Motor Function in Children with Neuro-Motor Impairments

2006 ◽  
Vol 23 (4) ◽  
pp. 339-355 ◽  
Author(s):  
Miriam Getz ◽  
Yeshayahu Hutzler ◽  
Adri Vermeer
Keyword(s):  
Motor Function ◽  
Motor Performance ◽  
Motor Impairments ◽  
Gross Motor ◽  
Gross Motor Function ◽  
Gross Motor Function Measure ◽  
Scale Scores ◽  
The Relationship ◽  
Pearson Correlations ◽  
Function Measure

The purpose of this study was to investigate the relationship between motor performance in the aquatic setting as measured by the Aquatic Independence Measure (AIM) to motor performance on land as measured by the Gross Motor Function Measure (GMFM) and the Pediatric Evaluation of Disability Inventory (PEDI). Fourty- nine children with neuro-motor impairments ages 3 to 7 participated in the study. Pearson correlations were applied to determine the relationships between the AIM and the GMFM, PEDI, and Gross Motor Function Classification System (GMFCS). Significant correlations were found between the total AIM and GMFM scores (r = 69, p < .01) and PEDI self-care sub-scale (r = .79, p < .01) as well as the PEDI mobility sub-scale scores (r = .35, p < .05). The water adjustment sub-scale as measured by the AIM showed the strongest relationship to motor performance on land as measured by the GMFM and PEDI in our sample of 49 children.

scholarly journals Assessing Motor Performance in Preschool Children: The Zurich Neuromotor Assessment-2 and the Movement Assessment Battery for Children-2

2021 ◽  
pp. 003151252110252
Author(s):  
Gerda van der Veer ◽  
Erica Kamphorst ◽  
Alexander Minnaert ◽  
Marja Cantell ◽  
Tanja H. Kakebeeke ◽  
...  
Keyword(s):  
Preschool Children ◽  
Young Children ◽  
Motor Skills ◽  
Motor Performance ◽  
Assessment Tools ◽  
Fine Motor ◽  
Assessment Battery ◽  
Movement Assessment ◽  
Zurich Neuromotor Assessment ◽  
Pearson Correlations

Comparing motor assessment tools that are available for young children is important in order to select the most appropriate clinical and research tools. Hence, this study compared motor performance assessed with the Zurich Neuromotor Assessment-2 (ZNA-2) to the Movement Assessment Battery for Children-2 (MABC-2). The sample consisted of 169 children, aged 3–5 years (87 boys; 51%). We used Pearson correlations to examine relationships between the ZNA-2 and MABC-2 component and total scores. In addition, Pearson correlations were performed between individual fine motor and balance items of the ZNA-2 and MABC-2. Results were that the total scores of the ZNA-2 and MABC-2 correlated moderately ( r = .40, p < .001). Non-significant to moderate correlations were found between components ( r = −.00 to .47) and between individual items of fine motor skills ( r = .04 to .38) and balance ( r = −.12 to .38). Thus, the ZNA-2 and MABC-2 measure partly similar and partly different aspects of motor performance.

Il vissuto di bambini e adolescenti con artrite idiopatica giovanile

2020 ◽  
Vol 39 (10) ◽  
pp. 638-641
Author(s):  
Lorenzoiara Mambelli ◽  
Agnese Menghi ◽  
Camilla Lama ◽  
Federico Marchetti
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Chronically Ill ◽  
Behavioural Problems ◽  
Psychological Care ◽  
Voluntary Withdrawal ◽  
Increased Risk ◽  
Rheumatology Unit ◽  
Chronically Ill Children ◽  
Important Drug

Chronically ill children show an increased risk of developing a psychological-psychiatric disorder, with an important impact on their quality of life. The paper describes all the cases of Juvenile Idiopathic Arthritis (JIA) in the Paediatric Rheumatology Unit in Ravenna with documented psychological-behavioural problems. 23% of juvenile idiopathic arthritis patients have psychological-behavioural problems and 9% have requested cognitivebehavioural therapy, with good results. One of the most significant aspects is the treatment with methotrexate (MTX), which is an important drug in the management of JIA cases and, as it is known, is burdened with side effects such as malaise and vomiting, even before its intake. Half of the patients on MTX therapy show this "intolerance", which sometimes also leads to the voluntary withdrawal of the drug. Therefore, an anticipatory approach to these issues and an adequate and timely psychological care are increasingly necessary.

scholarly journals Control of motor coordination by astrocytic tonic GABA release through modulation of excitation/inhibition balance in cerebellum

2018 ◽  
Vol 115 (19) ◽  
pp. 5004-5009 ◽  
Author(s):  
Junsung Woo ◽  
Joo Ok Min ◽  
Dae-Si Kang ◽  
Yoo Sung Kim ◽  
Guk Hwa Jung ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Motor Performance ◽  
Neuronal Excitability ◽  
Motor Coordination ◽  
Granule Cells ◽  
Cerebellar Granule Cells ◽  
Gaba Release ◽  
In Vivo Microdialysis ◽  
Tonic Inhibition

Tonic inhibition in the brain is mediated through an activation of extrasynaptic GABAA receptors by the tonically released GABA, resulting in a persistent GABAergic inhibitory action. It is one of the key regulators for neuronal excitability, exerting a powerful action on excitation/inhibition balance. We have previously reported that astrocytic GABA, synthesized by monoamine oxidase B (MAOB), mediates tonic inhibition via GABA-permeable bestrophin 1 (Best1) channel in the cerebellum. However, the role of astrocytic GABA in regulating neuronal excitability, synaptic transmission, and cerebellar brain function has remained elusive. Here, we report that a reduction of tonic GABA release by genetic removal or pharmacological inhibition of Best1 or MAOB caused an enhanced neuronal excitability in cerebellar granule cells (GCs), synaptic transmission at the parallel fiber-Purkinje cell (PF-PC) synapses, and motor performance on the rotarod test, whereas an augmentation of tonic GABA release by astrocyte-specific overexpression of MAOB resulted in a reduced neuronal excitability, synaptic transmission, and motor performance. The bidirectional modulation of astrocytic GABA by genetic alteration of Best1 or MAOB was confirmed by immunostaining and in vivo microdialysis. These findings indicate that astrocytes are the key player in motor coordination through tonic GABA release by modulating neuronal excitability and could be a good therapeutic target for various movement and psychiatric disorders, which show a disturbed excitation/inhibition balance.

PHYSICAL THERAPY INTERVENTION FOR PATIENT WITH EAST SYNDROME- A CASE STUDY.

2021 ◽  
pp. 74-77
Author(s):  
Kinjal Bagthariya(M.P.T)
Keyword(s):  
Physical Therapy ◽  
Motor Function ◽  
Motor Performance ◽  
Treatment Approach ◽  
Sensorineural Deafness ◽  
Gross Motor ◽  
East Syndrome ◽  
Therapy Intervention ◽  
Physical Therapy Intervention

EAST syndrome is autosomal recessive disorder due to mutations in gene KCNJ10, a gene encoding a potassium channel expressed in the brain, eye, ear and kidney. It is characterized by four cardinal features; Epilepsy, Ataxia, Sensorineural deafness, and renal salt-wasting Tubulopathy, thus the acronym EAST syndrome. It was rst described as a distinct clinical entity in 2009 by Bockenhauer and scholl, who named this condition EAST syndrome and SeSAME syndrome for Seizures, Sensorineural deafness, Ataxia, Mental retardation and Electrolyte imbalance respectively. Neurodevelopmental delay is evident in most patients with EAST syndrome that were old enough to be assessed; Thus, physiotherapy intervention also plays a vital role in EAST syndrome along with medical management. From physiotherapy perspective; symptomatic management to Improve overall health, wellbeing and motor control becomes ultimate goal in the patient with EAST syndrome. As there is no specic physical therapy treatment approach and no specic tool to evaluate function for children with EAST syndrome; for clinically presented delay development and ataxia, Neurodevelopment therapy (NDT) was utilized as treatment approach and Gross motor function measure (GMFM) & Gross motor performance measure (GMPM) were utilized for assessment in this case study to track progress on follow ups. Result showed marked improvement in GMFM and GMPM scores at follow ups and concluded that Physical therapy intervention improves the gross motor function as well as gross motor performance in patient with EAST syndrome.

scholarly journals A-58 Rare Case of Klinefelter Syndrome with 13/14 Balanced Translocation and Absence Epilepsy: Impact of Combined Genotypes on Cognitive Neuropsychological Phenotype

2019 ◽  
Vol 34 (6) ◽  
pp. 918-918
Author(s):  
S Shagalow ◽  
R Facchini ◽  
D Masur ◽  
E Weiss ◽  
S Schneider ◽  
...  
Keyword(s):  
Motor Coordination ◽  
Sex Chromosome ◽  
De Novo ◽  
Klinefelter Syndrome ◽  
Chromosome Rearrangement ◽  
Receptive Language ◽  
Absence Epilepsy ◽  
Language Therapy ◽  
Balanced Translocation ◽  
Increased Risk

Abstract Objective Klinefelter syndrome (KS) and Robertsonian translocation of 13/14 [rob t(13;14)] are the most common sex-chromosome disorder and chromosome rearrangement, respectively (Engels et al., 2008; Skakkebæk, Wallentin, & Gravholt, 2015). Both are associated with increased risk of cognitive/intellectual disability (ID). A case of KS and de novo (i.e., unbalanced) rob t(13;14) was previously reported (Gül & Şayli, 1994). A case of KS with balanced rob t(13;14) and well-controlled generalized absence epilepsy will be presented with consideration for pediatric neuropsychological practice. Method Neuropsychological evaluation of a 12-year-old, right-handed boy diagnosed with comorbid KS, rob t(13;14), and generalized absence epilepsy. Particular attention was given to language given his KS diagnosis. The patient is in a 12:1:1 self-contained classroom with speech-language therapy and social skills groups in place. The patient’s mother is confirmed to have rob t(13;14), whereas paternal contribution is unknown. Results Adolescent with a history of language difficulties, especially comprehension. Recent school-based WISC-V FSIQ was in the extremely low range (SS = 53), with weaker verbal comprehension and working memory. Academic achievement was globally very low. Expressive and receptive language, visual perception and motor coordination were extremely low to low average. Verbal list learning and visual attention were near average to average. Conclusions This case contributes to the very limited body of pediatric neuropsychological data on the combined genotype of KS with rob t(13;14) and absence epilepsy. Both the KS and rob t(13;14) cognitive phenotypes have been characterized as highly variable, with the comorbidity a likely increased risk for ID.

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