Cardiovascular manifestations of Hutchinson–Gilford progeria syndrome

2022 ◽  
pp. 1-3
Author(s):  
Andreia Palma ◽  
Patrícia V. Silva ◽  
António Pires
Keyword(s):  
Natural History ◽  
Cause Of Death ◽  
Cardiovascular Complications ◽  
Cardiac Abnormalities ◽  
History Of ◽  
Progeria Syndrome ◽  
Hutchinson Gilford Progeria Syndrome ◽  
Insight Into

Abstract Cardiovascular complications are the most frequent cause of death in patients with the Hutchinson–Gilford progeria syndrome. However, due to its rarity, studying the course of cardiac abnormalities has been a challenge. The cardiovascular phenotype helps to provide greater insight into the natural history of these abnormalities.

scholarly journals The spontaneous resolution of a vortex vein varix: case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sara L Weidmayer ◽  
Hakan Demirci
Keyword(s):  
Case Report ◽  
Natural History ◽  
Extended Period ◽  
Spontaneous Resolution ◽  
Case Presentation ◽  
Clinical Resolution ◽  
History Of ◽  
Vortex Vein ◽  
Insight Into

Abstract Background The natural course of a vortex vein varix, though not well understood, has been known to remain stable. However, here we report a novel case of a vortex vein varix that resolved after an extended period of monitoring. Case presentation An asymptomatic 96-year-old Caucasian man was found to have a vortex vein varix. At his previous examination 13 months prior, his fundus was normal. At 13 months of observation, his vortex vein varix become clinically undetectable. Further follow-up confirmed continued absence of the varix. Conclusion This case demonstrates the development then clinical resolution of a vortex vein varix with no clear identifiable factors for its evolution. This case is novel and offers new insight into the natural history of some vortex vein varices, implicating venous congestion as an instigator and venous collateralization as its alleviator, suggesting that vortex vein varices are likely more common than previously reported since some may be temporary and under-identified.

scholarly journals Early Airway Pathological Changes in Children: New Insights into the Natural History of Wheezing

2019 ◽  
Vol 8 (8) ◽  
pp. 1180 ◽  
Author(s):  
Matteo Bonato ◽  
Mariaenrica Tiné ◽  
Erica Bazzan ◽  
Davide Biondini ◽  
Marina Saetta ◽  
...  
Keyword(s):  
Natural History ◽  
Genetic Background ◽  
Current Knowledge ◽  
Persistent Asthma ◽  
Epidemiological Studies ◽  
Airflow Limitation ◽  
Clinical Expression ◽  
Heterogeneous Condition ◽  
History Of ◽  
Insight Into

Asthma is a heterogeneous condition characterized by reversible airflow limitation, with different phenotypes and clinical expressions. Although it is known that asthma is influenced by age, gender, genetic background, and environmental exposure, the natural history of the disease is still incompletely understood. Our current knowledge of the factors determining the evolution from wheezing in early childhood to persistent asthma later in life originates mainly from epidemiological studies. The underlying pathophysiological mechanisms are still poorly understood. The aim of this review is to converge epidemiological and pathological evidence early in the natural history of asthma to gain insight into the mechanisms of disease and their clinical expression.

scholarly journals Cardiac Abnormalities in Patients With Hutchinson-Gilford Progeria Syndrome

2018 ◽  
Vol 3 (4) ◽  
pp. 326 ◽  
Author(s):  
Ashwin Prakash ◽  
Leslie B. Gordon ◽  
Monica E. Kleinman ◽  
Ellen B. Gurary ◽  
Joseph Massaro ◽  
...  
Keyword(s):  
Cardiac Abnormalities ◽  
Progeria Syndrome ◽  
Hutchinson Gilford Progeria Syndrome

scholarly journals The Sense-organs and Perceptions of Fishes; with Remarks on the Supply of Bait

1890 ◽  
Vol 1 (3) ◽  
pp. 225-256 ◽  
Author(s):  
W. Bateson
Keyword(s):  
Natural History ◽  
Sense Organs ◽  
Marine Animals ◽  
Practical Solution ◽  
Biological Association ◽  
Marine Biological ◽  
Marine Biological Association ◽  
History Of ◽  
Insight Into

The Council of the Marine Biological Association appointed me, in 1889, to make observations on the perceptions of fishes, and especially on those which constitute the modes by which they hunt for and recognise their food. It was suggested that this subject should be treated in as wide a manner as possible, and in accordance with this suggestion I have endeavoured to utilize any opportunities which presented themselves of getting an insight into the natural history of marine animals. In addition to this I have also made some experiments towards the practical solution of the bait question, both by making artificial baits, and by endeavouring to preserve materials which are already in use for bait.

Evolution of the treatment of cerebral vasospasm

2006 ◽  
Vol 20 (6) ◽  
pp. 1-4 ◽  
Author(s):  
Scott Y. Rahimi ◽  
John H. Brown ◽  
Samuel D. Macomson ◽  
Michael A. Jensen ◽  
Cargill H. Alleyne
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Natural History ◽  
Cerebral Vasospasm ◽  
Successful Treatment ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Disease Process ◽  
Acute Setting ◽  
The Past ◽  
History Of ◽  
Insight Into

✓ Cerebral vasospasm following aneurysmal subarachnoid hemorrhage (SAH) is a disease process for which the lack of effective treatments has plagued neurosurgeons for decades. Historically, successful treatment after SAH in the acute setting was often followed by a rapid, uncontrollable deterioration in the subacute interval. Little was known regarding the nature and progression of this condition until the mid-1800s, when the disease was first described by Gull. Insight into the origin and natural history of cerebral vasospasm came slowly over the next 100 years, until the 1950s. Over the past five decades our understanding of cerebral vasospasm has expanded exponentially. This newly discovered information has been used by neurosurgeons worldwide for successful treatment of complications associated with vasospasm. Nevertheless, although great strides have been made toward elucidating the causes of cerebral vasospasm, a lasting cure continues to elude experts and the disease continues to wreak havoc on patients after aneurysmal SAH.

scholarly journals 1715: Enhancing Renal Lesions in Patients with Prior Normal Abdominal Imaging: Insight into the Natural History of Renal Cell Carcinoma

2006 ◽  
Vol 175 (4S) ◽  
pp. 551-551
Author(s):  
Paul L. Crispen ◽  
Aldiana Soljic ◽  
Richard E. Greenberg ◽  
David Y.T. Chen ◽  
Robert G. Uzzo
Keyword(s):  
Renal Cell Carcinoma ◽  
Natural History ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Abdominal Imaging ◽  
Renal Lesions ◽  
History Of ◽  
Insight Into

Natural History of Disseminated Coccidioidomycosis: Examination of the Veterans Affairs–Armed Forces Database

2020 ◽  
Author(s):  
Derek J Bays ◽  
George R Thompson ◽  
Susan Reef ◽  
Linda Snyder ◽  
Alana J Freifeld ◽  
...  
Keyword(s):  
Natural History ◽  
Pulmonary Nodules ◽  
Armed Forces ◽  
Veterans Affairs ◽  
Initial Infection ◽  
All Cause Mortality ◽  
History Of ◽  
Insight Into

Abstract Background The natural history of non–central nervous system (non-CNS) disseminated coccidioidomycosis (DCM) has not been previously characterized. The historical Veterans Affairs (VA)–Armed Forces coccidioidomycosis patient group provides a unique cohort of patients not treated with standard antifungal therapy, allowing for characterization of the natural history of coccidioidomycosis. Methods We conducted a retrospective study of 531 VA–Armed Forces coccidioidomycosis patients diagnosed between 1955–1958 and followed to 1966. Groups were identified as non-DCM (462 patients), DCM (44 patients), and CNS (25 patients). The duration of the initial infection, fate of the primary infection, all-cause mortality, and mortality secondary to coccidioidomycosis were assessed and compared between groups. Results Mortality due to coccidioidomycosis at the last known follow-up was significantly different across the groups: 0.65% in the non-DCM group, 25% in the DCM group, and 88% in the CNS group (P < .001). The primary fate of pulmonary infection demonstrated key differences, with pulmonary nodules observed in 39.61% of the non-DCM group, 13.64% of the DCM group, and 20% of the CNS group (P < .001). There were differences in cavity formation, with 34.20% in the non-DCM group, 9.09% in the DCM group, and 8% in the CNS group (P < .001). Dissemination was the presenting manifestation or was concurrent with the initial infection in 41% and 56% of patients in the non-CNS DCM and CNS groups, respectively. Conclusions This large, retrospective cohort study helps characterize the natural history of DCM, provides insight into the host immunologic response, and has direct clinical implications for the management and follow-up of patients.

scholarly journals Serial MRIs provide novel insight into natural history of optic pathway gliomas in patients with neurofibromatosis 1

2018 ◽  
Vol 13 (1) ◽  
Author(s):  
Laura Sellmer ◽  
Said Farschtschi ◽  
Marco Marangoni ◽  
Manraj K. S. Heran ◽  
Patricia Birch ◽  
...  
Keyword(s):  
Natural History ◽  
Neurofibromatosis 1 ◽  
Optic Pathway ◽  
History Of ◽  
Insight Into ◽  
Optic Pathway Gliomas
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