The Genetics of Obsessive-Compulsive Disorder: An Immunologic Perspective
Keyword(s):
ABSTRACTThis article presents a rationale for the hypothesis that an autoimmune mechanism might be involved in the pathogenesis of some forms of obsessive-compulsive aborder (OCO). Existing clinical studies suggesting that some individuals with OCD may have an autoimmune-mediated disorder are briefly summarized. A case example where intravenous immunoglobulin G has been successfully used to treat an adult with OCD spectrum disorder is presented. Preclinical data demonstrating that fragments from the group Αβ hemolytic streptococcus cell wall M proteins can generate antibodies that bind to rat and human tissue are also presented.
2004 ◽
Vol 16
(3)
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pp. 163-166
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1990 ◽
Vol 89
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pp. 554-560
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1999 ◽
Vol 21
(6)
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pp. 514-517
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1989 ◽
Vol 155
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pp. 32-40
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