Plasma exchange and intravenous immunoglobulin improved symptoms in a subtype of obsessive compulsive disorder and tic disorders

Issler CK, Monkul ES, Amaral JAMS, Tamada RS, Shavitt RG, Miguel EC, Lafer B. Bipolar disorder and comorbid obsessive-compulsive disorder is associated with higher rates of anxiety and impulse control disorders.Objective:Although bipolar disorder (BD) with comorbid obsessive-compulsive disorder (OCD) is highly prevalent, few controlled studies have assessed this comorbidity. The objective of this study was to investigate the clinical characteristics and expression of comorbid disorders in female BD patients with OCD.Method:We assessed clinically stable female outpatients with BD: 15 with comorbid OCD (BD+OCD group) and 15 without (BD/no-OCD group). All were submitted to the Structured Clinical Interview for DSM-IV, with additional modules for the diagnosis of kleptomania, trichotillomania, pathological gambling, onychophagia and skin picking.Results:The BD+OCD patients presented more chronic episodes, residual symptoms and previous depressive episodes than the BD/no-OCD patients. Of the BD+OCD patients, 86% had a history of treatment-emergent mania, compared with only 40% of the BD/no-OCD patients. The following were more prevalent in the BD+OCD patients than the BD/no-OCD patients: any anxiety disorder other than OCD; impulse control disorders; eating disorders; and tic disorders.Conclusion:Female BD patients with OCD may represent a more severe form of disorder than those without OCD, having more depressive episodes and residual symptoms, and being at a higher risk for treatment-emergent mania, as well as presenting a greater anxiety and impulse control disorder burden.

Download Full-text

Relative Contribution of Attention-Deficit Hyperactivity Disorder, Obsessive-Compulsive Disorder, and Tic Severity to Social and Behavioral Problems in Tic Disorders

Journal of Developmental & Behavioral Pediatrics ◽

10.1097/00004703-200408000-00007 ◽

2004 ◽

Vol 25 (4) ◽

pp. 272-279 ◽

Cited By ~ 48

Author(s):

PIETER J. HOEKSTRA ◽

MARK-PETER STEENHUIS ◽

PIETER W. TROOST ◽

JAKOB KORF ◽

CEES G.M. KALLENBERG ◽

...

Keyword(s):

Attention Deficit Hyperactivity Disorder ◽

Obsessive Compulsive Disorder ◽

Behavioral Problems ◽

Attention Deficit ◽

Tic Disorders ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Hyperactivity Disorder ◽

Relative Contribution ◽

Tic Severity

Download Full-text

A total-population multigenerational family clustering study of autoimmune diseases in obsessive–compulsive disorder and Tourette’s/chronic tic disorders

Molecular Psychiatry ◽

10.1038/mp.2017.215 ◽

2017 ◽

Vol 23 (7) ◽

pp. 1652-1658 ◽

Cited By ~ 24

Author(s):

D Mataix-Cols ◽

E Frans ◽

A Pérez-Vigil ◽

R Kuja-Halkola ◽

C Gromark ◽

...

Keyword(s):

Autoimmune Diseases ◽

Obsessive Compulsive Disorder ◽

Total Population ◽

Tic Disorders ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Multigenerational Family ◽

Chronic Tic Disorders

Download Full-text

16. Obsessive-Compulsive Disorder and Tic Disorders

Mental Health Disorders in Adolescents ◽

10.36019/9780813552347-019 ◽

2019 ◽

pp. 227-247

Keyword(s):

Obsessive Compulsive Disorder ◽

Tic Disorders ◽

Obsessive Compulsive ◽

Compulsive Disorder

Download Full-text

Inflammation in Tic Disorders and Obsessive-Compulsive Disorder: Are PANS and PANDAS a Path Forward?

Journal of Child Neurology ◽

10.1177/0883073819848635 ◽

2019 ◽

Vol 34 (10) ◽

pp. 598-611 ◽

Cited By ~ 6

Author(s):

Donald L. Gilbert

Keyword(s):

Obsessive Compulsive Disorder ◽

Tic Disorders ◽

Published Data ◽

Clinical Practices ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Scientific Questions

This review and commentary is the product of an invited lecture called “Autoimmunity: PANS/PANDAS” presented at the 2018 Neurobiology of Diseases in Children Symposium in Chicago, IL. The talk addressed clinical and scientific questions and recently published data. At this time, among highly experienced and respected clinicians and researchers spanning relevant disciplines, there is substantial controversy regarding a role for inflammation in producing tics and obsessive-compulsive disorder. This commentary summarizes these controversies, discusses reasons for opposing views on best clinical practices, and concludes with suggestions for pathways forward.

Download Full-text

Comorbidity in Juvenile Obsessive—Compulsive Disorder: A Report from India

The Canadian Journal of Psychiatry ◽

10.1177/070674370004500307 ◽

2000 ◽

Vol 45 (3) ◽

pp. 274-278 ◽

Cited By ~ 25

Author(s):

YC Janardhan Reddy ◽

P Srinivas Reddy ◽

S Srinath ◽

S Khanna ◽

SP Sheshadri ◽

...

Keyword(s):

Bipolar Disorder ◽

Children And Adolescents ◽

Obsessive Compulsive Disorder ◽

Structured Interview ◽

Child And Adolescent Psychiatry ◽

Tic Disorders ◽

Obsessive Compulsive ◽

Interview Schedule ◽

Compulsive Disorder ◽

Disruptive Disorders

Objective: Using minimal exclusion criteria, to assess systematically the psychiatric comorbidity in children and adolescents with obsessive–compulsive disorder (OCD) and compare the findings with those of previous studies. Method: Fifty-four children and adolescents who satisfied DSM-III-R criteria for OCD were assessed using a structured interview schedule, the Children's version of the Yale-Brown Obsessive Compulsive Scale (CY-BOCS), and the questionnaire for tic disorders. All 54 subjects were recruited from the Child and Adolescent Psychiatry (CAP) services of the National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, South India. Diagnoses were determined consensually after a review of all the available data. Results: Comorbidity was found in 69% of the sample: 22% were diagnosed with disruptive disorders; 20% met criteria for mood disorders; 19% had anxiety disorders; and 17% had tic disorders. Only 1 subject had bipolar disorder, and none had psychosis. The rates for individual diagnoses—in particular, the rates for disruptive disorders, bipolar disorder, and psychosis—were considerably lower than those reported in previous studies. Conclusions: Patterns of comorbidity in this study differed from those previously reported. Novel patterns of comorbidity with disruptive disorders, bipolar disorder, and psychosis reported in a few recent studies were not replicated in this study. These differences are probably due to different ascertainment methods. Comorbidity needs to be assessed in large epidemiological samples before definite associations can be made between certain comorbid disorders and juvenile OCD.

Download Full-text

Comparison of clinical features among youth with tic disorders, obsessive–compulsive disorder (OCD), and both conditions

Psychiatry Research ◽

10.1016/j.psychres.2009.11.013 ◽

2010 ◽

Vol 178 (2) ◽

pp. 317-322 ◽

Cited By ~ 54

Author(s):

Adam B. Lewin ◽

Susanna Chang ◽

James McCracken ◽

Melissa McQueen ◽

John Piacentini

Keyword(s):

Obsessive Compulsive Disorder ◽

Clinical Features ◽

Tic Disorders ◽

Obsessive Compulsive ◽

Compulsive Disorder

Download Full-text

Early Onset Obsessive-Compulsive Disorder With and Without Tics

CNS Spectrums ◽

10.1017/s1092852900023014 ◽

2009 ◽

Vol 14 (7) ◽

pp. 362-370 ◽

Cited By ~ 30

Author(s):

Maria Alice de Mathis ◽

Juliana B. Diniz ◽

Roseli G. Shavitt ◽

Albina R. Torres ◽

Ygor A. Ferrão ◽

...

Keyword(s):

Obsessive Compulsive Disorder ◽

Early Onset ◽

Age Of Onset ◽

Age At Onset ◽

Clinical Manifestations ◽

Tic Disorders ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Diagnostic And Statistical Manual ◽

History Of

ABSTRACTIntroduction: Research suggests that obsessive-compulsive disorder (OCD) is not a unitary entity, but rather a highly heterogeneous condition, with complex and variable clinical manifestations.Objective: The aims of this study were to compare clinical and demographic characteristics of OCD patients with early and late age of onset of obsessive-compulsive symptoms (OCS); and to compare the same features in early onset OCD with and without tics. The independent impact of age at onset and presence of tics on comorbidity patterns was investigated.Methods: Three hundred and thirty consecutive outpatients meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for OCD were evaluated: 160 patients belonged to the “early onset” group (EOG): before 11 years of age, 75 patients hadResults: The EOG had a predominance of males, higher frequency of family history of OCS, higher mean scores on the “aggression/violence” and “miscellaneous” dimensions, and higher mean global DY-BOCS scores. Patients with EOG without tic disorders presented higher mean global DY-BOCS scores and higher mean scores in the “contamination/cleaning” dimension.Conclusion: The current results disentangle some of the clinical overlap between early onset OCD with and without tics.

Download Full-text