Comparison of Weights of Twin Fetuses and of their Incisors

1970 ◽  
Vol 19 (1-2) ◽  
pp. 79-79 ◽  
Author(s):  
M. V. Stack

Weights of developing incisors in 10 pairs of twin fetuses have previously been related to ages in order to compare dental growth status (Stack, 1963). Ages (T0) at which weights (W) of mineralised portions of teeth of the temporary dentition become significant have been computed (Stack, 1968), using a Fortran program giving maximum likelihood estimates of the required parameters, based on the statistical model of Angleton and Pettus (1966).Availability of the additional parameter T0 allows a reexamination of the previous data, now fortified by observations on incisors from five further pairs of twin fetuses. Estimates of ages were made from the relationship (T—T0) = k·W½, where values for upper and lower central incisors were 2.0 and 2.8 for k, 19.5 and 18.5 for T0, respectively. Less reliable estimates were obtained from the lateral incisors. These values were computed from observations on 40 dentitions from normal singleton fetuses. Ages were also estimated from tabulated body weights (Documenta Geigy).

Author(s):  
Vijitashwa Pandey ◽  
Deborah Thurston

Design for disassembly and reuse focuses on developing methods to minimize difficulty in disassembly for maintenance or reuse. These methods can gain substantially if the relationship between component attributes (material mix, ease of disassembly etc.) and their likelihood of reuse or disposal is understood. For products already in the marketplace, a feedback approach that evaluates willingness of manufacturers or customers (decision makers) to reuse a component can reveal how attributes of a component affect reuse decisions. This paper introduces some metrics and combines them with ones proposed in literature into a measure that captures the overall value of a decision made by the decision makers. The premise is that the decision makers would choose a decision that has the maximum value. Four decisions are considered regarding a component’s fate after recovery ranging from direct reuse to disposal. A method on the lines of discrete choice theory is utilized that uses maximum likelihood estimates to determine the parameters that define the value function. The maximum likelihood method can take inputs from actual decisions made by the decision makers to assess the value function. This function can be used to determine the likelihood that the component takes a certain path (one of the four decisions), taking as input its attributes, which can facilitate long range planning and also help determine ways reuse decisions can be influenced.


2009 ◽  
Vol 12 (1) ◽  
pp. 79-85 ◽  
Author(s):  
Jill Hardin ◽  
Steve Selvin ◽  
Suzan L. Carmichael ◽  
Gary M. Shaw

AbstractThis study presents a general model of two binary variables and applies it to twin sex pairing data from 21 twin data sources to estimate the frequency of dizygotic twins. The purpose of this study is to clarify the relationship between maximum likelihood and Weinberg's differential rule zygosity estimation methods. We explore the accuracy of these zygosity estimation measures in relation to twin ascertainment methods and the probability of a male. Twin sex pairing data from 21 twin data sources representing 15 countries was collected for use in this study. Maximum likelihood estimation of the probability of dizygotic twins is applied to describe the variation in the frequency of dizygotic twin births. The differences between maximum likelihood and Weinberg's differential rule zygosity estimation methods are presented as a function of twin data ascertainment method and the probability of a male. Maximum likelihood estimation of the probability of dizygotic twins ranges from 0.083 (95% approximate CI: 0.082, 0.085) to 0.750 (95% approximate CI: 0.749, 0.752) for voluntary ascertainment data sources and from 0.374 (95% approximate CI: 0.373, 0.375) to 0.987 (95% approximate CI: 0.959, 1.016) for active ascertainment data sources. In 17 of the 21 twin data sources differences of 0.01 or less occur between maximum likelihood and Weinberg zygosity estimation methods. The Weinberg and maximum likelihood estimates are negligibly different in most applications. Using the above general maximum likelihood estimate, the probability of a dizygotic twin is subject to substantial variation that is largely a function of twin data ascertainment method.


Genetics ◽  
2001 ◽  
Vol 159 (4) ◽  
pp. 1779-1788 ◽  
Author(s):  
Carlos D Bustamante ◽  
John Wakeley ◽  
Stanley Sawyer ◽  
Daniel L Hartl

Abstract In this article we explore statistical properties of the maximum-likelihood estimates (MLEs) of the selection and mutation parameters in a Poisson random field population genetics model of directional selection at DNA sites. We derive the asymptotic variances and covariance of the MLEs and explore the power of the likelihood ratio tests (LRT) of neutrality for varying levels of mutation and selection as well as the robustness of the LRT to deviations from the assumption of free recombination among sites. We also discuss the coverage of confidence intervals on the basis of two standard-likelihood methods. We find that the LRT has high power to detect deviations from neutrality and that the maximum-likelihood estimation performs very well when the ancestral states of all mutations in the sample are known. When the ancestral states are not known, the test has high power to detect deviations from neutrality for negative selection but not for positive selection. We also find that the LRT is not robust to deviations from the assumption of independence among sites.


Genetics ◽  
2000 ◽  
Vol 155 (3) ◽  
pp. 1429-1437
Author(s):  
Oliver G Pybus ◽  
Andrew Rambaut ◽  
Paul H Harvey

Abstract We describe a unified set of methods for the inference of demographic history using genealogies reconstructed from gene sequence data. We introduce the skyline plot, a graphical, nonparametric estimate of demographic history. We discuss both maximum-likelihood parameter estimation and demographic hypothesis testing. Simulations are carried out to investigate the statistical properties of maximum-likelihood estimates of demographic parameters. The simulations reveal that (i) the performance of exponential growth model estimates is determined by a simple function of the true parameter values and (ii) under some conditions, estimates from reconstructed trees perform as well as estimates from perfect trees. We apply our methods to HIV-1 sequence data and find strong evidence that subtypes A and B have different demographic histories. We also provide the first (albeit tentative) genetic evidence for a recent decrease in the growth rate of subtype B.


Machines ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 4
Author(s):  
Panagiotis Kyratsis ◽  
Anastasios Tzotzis ◽  
Angelos Markopoulos ◽  
Nikolaos Tapoglou

In this study, the development of a 3D Finite Element (FE) model for the turning of AISI-D3 with ceramic tooling is presented, with respect to four levels of cutting speed, feed, and depth of cut. The Taguchi method was employed in order to create the orthogonal array according to the variables involved in the study, reducing this way the number of the required simulation runs. Moreover, the possibility of developing a prediction model based on well-established statistical tools such as the Response Surface Methodology (RSM) and the Analysis of Variance (ANOVA) was examined, in order to further investigate the relationship between the cutting speed, feed, and depth of cut, as well as their influence on the produced force components. The findings of this study point out an increased correlation between the experimental results and the simulated ones, with a relative error below 10% for most tests. Similarly, the values derived from the developed statistical model indicate a strong agreement with the equivalent numerical values due to the verified adequacy of the statistical model.


1975 ◽  
Vol 12 (S1) ◽  
pp. 239-259 ◽  
Author(s):  
D. Vere-Jones

This paper is an attempt to interpret and extend, in a more statistical setting, techniques developed by D. L. Snyder and others for estimation and filtering for doubly stochastic point processes. The approach is similar to the Kalman-Bucy approach in that the updating algorithms can be derived from a Bayesian argument, and lead ultimately to equations which are similar to those occurring in stochastic approximation theory. In this paper the estimates are derived from a general updating formula valid for any point process. It is shown that almost identical formulae arise from updating the maximum likelihood estimates, and on this basis it is suggested that in practical situations the sequence of estimates will be consistent and asymptotically efficient. Specific algorithms are derived for estimating the parameters in a doubly stochastic process in which the rate alternates between two levels.


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