Adjuvant radiotherapy in primary cardiac sarcoma: case report and literature review

Abstract Background: Primary cardiac sarcoma (PCS) is a rare malignancy, and intimal cardiac sarcoma is the rarest. The prognosis is poor with mean survival of 3–12 months even with complete radical resection. There has been no randomised controlled trial or standard guidelines for management of cardiac sarcomas. Treatment is extrapolated from case reports and series. Case presentation: A 59-year-old male diagnosed with primary intimal cardiac sarcoma underwent wide local excision with positive margins. Adjuvant radiotherapy to a total dose of 60 Gray (Gy) was given with good tolerance. Conclusions: Intimal cardiac sarcoma is rare. The risk of local recurrence is high, and efforts must be made to elucidate the role and usefulness of radiotherapy and chemotherapy in these tumours.

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Wernicke-Korsakoff Syndrome in Hyperemesis Gravidarum: A Case Report and Literature Review

The Neurohospitalist ◽

10.1177/1941874420953027 ◽

2020 ◽

pp. 194187442095302

Author(s):

Gerald T. Pagaling ◽

Adrian I. Espiritu ◽

Carl Froilan D. Leochico ◽

Vida Margarette D. Andal ◽

Krystle Anne R. Blasco ◽

...

Keyword(s):

Hyperemesis Gravidarum ◽

Case Reports ◽

Controlled Trial ◽

Occipital Lobe ◽

First Trimester ◽

Case Presentation ◽

Beneficial Effects ◽

Korsakoff Syndrome ◽

Evidence Review ◽

Filipino Woman

Background: Wernicke-Korsakoff syndrome (WKS) is a triad of ophthalmoplegia, ataxia and memory deficits due to thiamine insufficiency resulting from under- or untreated Wernicke’s encephalopathy (WE), which may be associated with hyperemesis gravidarum (HEG). Case presentation: We present a case of a 36-year-old Filipino woman in her first trimester with HEG, along with the WKS triad and abnormal hyperintense signals in the bilateral thalami and midbrain, left occipital lobe, periaqueductal gray matter and pontine periventricular areas. Neurologic deficits partially improved but persisted despite intravenous thiamine administration. Evidence review: A review of current treatments for WE, and the prevention and neurocognitive recovery of WKS was done. The beneficial effects of thiamine for acute WKS are supported by several case reports and clinical experience. Evidence from one randomized controlled trial wherein thiamine was given in various doses for treating WE or preventing WKS in an alcohol-dependent population is limited by methodological issues. Rehabilitation and pharmacotherapy for neurocognitive recovery seems promising, but they have inadequate evidentiary support. More robust studies on multi-modal strategies are warranted to facilitate the neurocognitive recovery of patients with WKS.

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Mechanical thrombectomy in children and adolescents: report of five cases and literature review

Stroke and Vascular Neurology ◽

10.1136/svn-2018-000181 ◽

2018 ◽

Vol 3 (4) ◽

pp. 245-252 ◽

Cited By ~ 5

Author(s):

Pervinder Bhogal ◽

Victoria Hellstern ◽

Muhammad AlMatter ◽

Oliver Ganslandt ◽

Hansjörg Bäzner ◽

...

Keyword(s):

Ischaemic Stroke ◽

Mechanical Thrombectomy ◽

Case Reports ◽

Controlled Trial ◽

Case Series ◽

Postoperative Outcome ◽

Individual Case ◽

Older Children ◽

Advantages And Disadvantages ◽

Randomised Controlled

BackgroundPaediatric arterial ischaemic stroke is an important cause of morbidity and mortality among children. Currently, there are no recommendations regarding mechanical thrombectomy in children despite overwhelming evidence of improved outcomes in adults. Therefore, the need for individual case reports and case series is important to highlight potential advantages and disadvantages in this approach.Case descriptionsWe retrospectively searched our prospectively maintained database of patients undergoing mechanical thrombectomy for ischaemic stroke. We describe five children, aged between 7 and 17, who underwent mechanical thrombectomy for acute ischaemic stroke. We provide an account of their clinical presentations, operative treatment and postoperative outcome.DiscussionMechanical thrombectomy in children, especially older children, can be performed safely and with existing devices. Although a randomised controlled trial would provide compelling evidence of the potential advantages to this technique, the lack of this should not prevent the use of this procedure by trained neurointerventionists.

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There is no place for the psychoanalytic case report in the British Journal of Psychiatry

The British Journal of Psychiatry ◽

10.1192/bjp.bp.109.064451 ◽

2009 ◽

Vol 195 (6) ◽

pp. 483-487 ◽

Cited By ~ 14

Author(s):

Lewis Wolpert ◽

Peter Fonagy

Keyword(s):

Mental Health ◽

British Journal ◽

Clinical Utility ◽

Single Case ◽

Case Reports ◽

Controlled Trial ◽

Evidence Based ◽

The Status ◽

Randomised Controlled ◽

Scientific Testing

SummaryAs evidence-based mental health and the randomised controlled trial come to dominate the content of major psychiatric journals, the status and clinical utility of single case reports have been increasingly questioned. Arguably, owing to their subjective, anecdotal nature and unsuitability for rigorous scientific testing, this is particularly true of psychoanalytic case studies. Professor Peter Fonagy and Professor Lewis Wolpert debate here whether or not there is a place for such case reports in the British Journal of Psychiatry.

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