Vitamin D fortification and seasonality of birth in type 1 diabetic cases: D-tect study

Fortification of margarine with vitamin D was mandatory in Denmark during 1961–1985. The aim of the study was to assess whether gestational and early infancy exposure to margarine fortification was associated with seasonality of birth in Danish type 1 diabetes (T1D) patients. The risks of T1D in Danes born during various exposure periods around margarine fortification termination in 1985 were analyzed. As expected, the T1D hazards in males unexposed to margarine fortification and born in spring were higher than in males born in autumn: relevant hazard ratios (95% confidence intervals) in various exposure groups ranged from 1.74 (1.112/2.708) to 37.43 (1.804/776.558). There were no indications of seasonality of birth in males exposed to fortification, nor in both exposed and unexposed females. The study suggests that early life exposure to low-dose vitamin D from fortified food eliminates seasonality of birth in T1D male patients. Further studies are required to investigate the identified gender differences.

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Vitamin D deficiency in early life accelerates Type 1 diabetes in non-obese diabetic mice

Diabetologia ◽

10.1007/s00125-004-1329-3 ◽

2004 ◽

Vol 47 (3) ◽

pp. 451-462 ◽

Cited By ~ 146

Author(s):

A. Giulietti ◽

C. Gysemans ◽

K. Stoffels ◽

E. van Etten ◽

B. Decallonne ◽

...

Keyword(s):

Vitamin D ◽

Type 1 Diabetes ◽

Vitamin D Deficiency ◽

Early Life ◽

Diabetic Mice

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Maternal and Early Life Iron Intake and Risk of Childhood Type 1 Diabetes: A Danish Case-Cohort Study

Nutrients ◽

10.3390/nu11040734 ◽

2019 ◽

Vol 11 (4) ◽

pp. 734 ◽

Cited By ~ 2

Author(s):

Steffen Thorsen ◽

Thorhallur Halldorsson ◽

Anne Bjerregaard ◽

Sjurdur Olsen ◽

Jannet Svensson

Keyword(s):

Type 1 Diabetes ◽

Early Life ◽

Large Scale ◽

Iron Supplementation ◽

Cox Regression ◽

Hazard Ratios ◽

Childhood Type 1 Diabetes ◽

Diabetes Register ◽

Childhood Type

Background: Iron overload has been associated with diabetes. Studies on iron exposure during pregnancy and in early life and risk of childhood type 1 diabetes (T1D) are sparse. We investigated whether iron supplementation during pregnancy and early in life were associated with risk of childhood T1D. Methods: In a case-cohort design, we identified up to 257 children with T1D (prevalence 0.37%) from the Danish National Birth Cohort through linkage with the Danish Childhood Diabetes Register. The primary exposure was maternal pure iron supplementation (yes/no) during pregnancy as reported in interview two at 30 weeks of gestation (n = 68,497 with iron supplement data). We estimated hazard ratios (HRs) using weighted Cox regression adjusting for multiple confounders. We also examined if offspring supplementation during the first 18 months of life was associated with later risk of T1D. Results: Maternal iron supplementation was not associated with later risk of T1D in the offspring HR 1.05 (95% CI: 0.76–1.45). Offspring intake of iron droplets during the first 18 months of life was inversely associated with risk of T1D HR 0.74 (95% CI: 0.55–1.00) (ptrend = 0.03). Conclusions: Our large-scale prospective study demonstrated no harmful effects of iron supplementation during pregnancy and in early life in regard to later risk of childhood T1D in the offspring.

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Early-life exposure to gut microbiota from disease-protected mice does not impact disease outcome in type 1 diabetes susceptible NOD mice

Immunology and Cell Biology ◽

10.1111/imcb.12201 ◽

2018 ◽

Vol 97 (1) ◽

pp. 97-103 ◽

Cited By ~ 3

Author(s):

Jane A Mullaney ◽

Juliette E Stephens ◽

Brooke E Geeling ◽

Emma E Hamilton-Williams

Keyword(s):

Type 1 Diabetes ◽

Gut Microbiota ◽

Early Life ◽

Nod Mice ◽

Disease Outcome ◽

Early Life Exposure

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Regulation of type 1 diabetes development and B-cell activation in nonobese diabetic mice by early life exposure to a diabetogenic environment

PLoS ONE ◽

10.1371/journal.pone.0181964 ◽

2017 ◽

Vol 12 (8) ◽

pp. e0181964 ◽

Cited By ~ 8

Author(s):

Alessandra De Riva ◽

Maja Wållberg ◽

Francesca Ronchi ◽

Richard Coulson ◽

Andrew Sage ◽

...

Keyword(s):

Type 1 Diabetes ◽

Early Life ◽

Cell Activation ◽

Diabetic Mice ◽

B Cell Activation ◽

Nonobese Diabetic ◽

Early Life Exposure ◽

Diabetes Development ◽

Nonobese Diabetic Mice

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Vitamin D Deficiency Likely in Youths With Type 1 Diabetes

Pediatric News ◽

10.1016/s0031-398x(09)70008-6 ◽

2009 ◽

Vol 43 (1) ◽

pp. 4

Author(s):

HEIDI SPLETE

Keyword(s):

Vitamin D ◽

Type 1 Diabetes ◽

Vitamin D Deficiency

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Levels of 25(OH)vitamin D in children and adolescents with type 1 diabetes mellitus and in healthy controls in Bulgarian population

Bone Abstracts ◽

10.1530/boneabs.2.p199 ◽

2013 ◽

Author(s):

Slavcheva Olga ◽

Konstantinova Maia ◽

Tsekova Adelina ◽

Savova Radka ◽

Arshinkova Margarita

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Children And Adolescents ◽

Healthy Controls ◽

25 Oh Vitamin D ◽

Bulgarian Population

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Genetic susceptibility to type 1 diabetes: genomic variants in the vitamin D pathway

Endocrine Abstracts ◽

10.1530/endoabs.59.p057 ◽

2018 ◽

Author(s):

Joana Almeida ◽

Dircea Rodrigues ◽

Franscisco Carrilho ◽

Joana Guimaraes ◽

Manuel C Lemos

Keyword(s):

Vitamin D ◽

Type 1 Diabetes ◽

Genetic Susceptibility ◽

Genomic Variants

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Vitamin D status and bone metabolism in adult patients with Type 1 diabetes mellitus

Endocrine Abstracts ◽

10.1530/endoabs.63.p614 ◽

2019 ◽

Author(s):

Eleftheria Barmpa ◽

Spyros Karamagiolis ◽

Stelios Tigas ◽

Georgios N Koukoulis ◽

Alexandra Bargiota

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Bone Metabolism ◽

Adult Patients ◽

Vitamin D Status

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Diabetes and osteoporosis

Orvosi Hetilap ◽

10.1556/oh.2011.29154 ◽

2011 ◽

Vol 152 (29) ◽

pp. 1161-1166 ◽

Cited By ~ 4

Author(s):

Zsuzsanna Valkusz

Keyword(s):

Vitamin D ◽

Type 1 Diabetes ◽

Bone Mass ◽

Fragility Fractures ◽

Vitamin D Supplementation ◽

Bone Collagen ◽

Skeletal Changes ◽

Glucagon Like Peptide 1 ◽

Bone Quantity

Over the last decades a considerable amount of data has accumulated to indicate that metabolic and endocrine alterations of diabetes affect bone quantity and quality. These skeletal changes may increase the risk of bone fracture. There is strong evidence that in type 1 diabetes the decreased bone mass, lack of insulin and insulin-like growth factor-1, dysregulation of adipokines, and increased levels of proinflammatory cytokines are in the background of fragility fractures. In type 2 diabetes hyperinsulinemia, insulin resistance and increased body weight may result in an increase of bone mass; however, accumulation of advanced glycation end products within the bone collagen driven by glucotoxicity may increase the cortical porosity. There is a higher incidence of falls resulting from diabetes-related co-morbidities such as diabetic retinopathy, peripheral neuropathy, hypoglycemic episodes and sometimes from the medications. Vitamin D deficiency has special impact on glucose metabolism and the prevalence of diabetes. Vitamin D supplementation in childhood can decrease incidence of type 1 diabetes by 80%. The effect of thiazolidinediones, glucagon-like peptide-1 agonists and metformin, agents for treatment of diabetes open a new connection between bone, carbohydrate and fat metabolism. Orv. Hetil., 2011, 152, 1161–1166.

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