scholarly journals Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age: A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project

2016 ◽  
Vol 19 (2) ◽  
pp. 112-124 ◽  
Author(s):  
Yoshie Yokoyama ◽  
Aline Jelenkovic ◽  
Reijo Sund ◽  
Joohon Sung ◽  
John L. Hopper ◽  
...  

We analyzed birth order differences in means and variances of height and body mass index (BMI) in monozygotic (MZ) and dizygotic (DZ) twins from infancy to old age. The data were derived from the international CODATwins database. The total number of height and BMI measures from 0.5 to 79.5 years of age was 397,466. As expected, first-born twins had greater birth weight than second-born twins. With respect to height, first-born twins were slightly taller than second-born twins in childhood. After adjusting the results for birth weight, the birth order differences decreased and were no longer statistically significant. First-born twins had greater BMI than the second-born twins over childhood and adolescence. After adjusting the results for birth weight, birth order was still associated with BMI until 12 years of age. No interaction effect between birth order and zygosity was found. Only limited evidence was found that birth order influenced variances of height or BMI. The results were similar among boys and girls and also in MZ and DZ twins. Overall, the differences in height and BMI between first- and second-born twins were modest even in early childhood, while adjustment for birth weight reduced the birth order differences but did not remove them for BMI.

2021 ◽  
Author(s):  
Zeinab Hemati ◽  
Nafiseh Mozafarian ◽  
Ramin Heshmat ◽  
Hadith Rastad ◽  
Hanieh-Sadat Ejtahed ◽  
...  

Abstract Background This study aimed to evaluate the association of the number of family children and birth order with later body mass index (BMI) in a pediatric population. Methods This cross-sectional nationwide study was conducted in the framework of the fifth survey of a national school-based surveillance program, entitled Childhood and Adolescence Surveillance and PreventIon of Adult Noncommunicable disease (CASPIAN-V) Study. Participants were 14,400 students, aged 7–18 years, who were selected by random cluster sampling from 30 provinces in Iran. Multinomial regression models were used to evaluate the odds ratio (OR) and 95% confidence intervals (95% CI) of the number of family children or the birth order for later excess weight. Results The first-born children had significantly higher OR for obesity, and the third-born children had higher OR of underweight compared to the first-born ones (OR 1.22, 95% CI 1.05–1.42). Moreover, children within the three-, four-, and five-child families had higher OR of underweight than those with one-child families (OR 0.88, 95% CI 0.77- 1). Conclusion The birth order and number of children were associated with underweight and overweight or obesity in children and adolescents. Future studies are necessary to assess the underlying determinants.


2020 ◽  
Vol 222 ◽  
pp. 120-126.e3
Author(s):  
Katharina Stock ◽  
Rajini Nagrani ◽  
Nina Gande ◽  
Benoit Bernar ◽  
Anna Staudt ◽  
...  

2015 ◽  
Vol 18 (5) ◽  
pp. 557-570 ◽  
Author(s):  
Aline Jelenkovic ◽  
Yoshie Yokoyama ◽  
Reijo Sund ◽  
Chika Honda ◽  
Leonie H Bogl ◽  
...  

A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.


2019 ◽  
Vol 25 ◽  
pp. 268-269
Author(s):  
Bolanle Okunowo ◽  
Ifedayo Odeniyi ◽  
Oluwarotimi Olopade ◽  
Olufemi Fasanmade ◽  
Omololu Adegbola ◽  
...  

1970 ◽  
Vol 25 (1) ◽  
pp. 9-13
Author(s):  
S Jahan ◽  
TR Das ◽  
KB Biswas

Background and Aims: Cord blood leptin may reflect the leptinemic status of a newborn at birth more accurately than the leptin values of blood collected from other sites. The present study was undertaken to determine the relationship of cord serum leptin concentration at birth with neonatal and maternal anthropometric parameters. Materials and Methods: Blood was taken from the umbilical cord of the babies at delivery. Maternal anthropometric measurements were recorded at admission for delivery. Neonatal anthropometric measurements were recorded within 48 hours after delivery. Linear regression analysis was used to explore the relationship between cord serum leptin concentration and anthropometric parameters of the baby and the mother. Both Serum leptin and serum C-peptide levels were measured by chemiluminescence-based ELISA method. Results: The leptin concentration (ng/ml, mean±SD) in cord blood was 39.13±14.44. Cord leptin levels correlated with birth weight (r=0.673, p<0.0001), ponderal index (r=0.732, p<0.0001) but it did not correlate with maternal body mass index, gestational age (r=0.135, p=0.349) at delivery or cord serum C-peptide concentration (r=-0.049, p=0.735) or placental weight (r=0.203, p=0.157). Conclusion: There are associations between cord leptin concentration at delivery and birth weight, ponderal index (PI) of the babies but not body mass index (BMI) of the mothers. High leptin levels of the baby could represent an important feedback modulator of substrate supply and subsequently for adipose tissue status during late gestation. (J Bangladesh Coll Phys Surg 2007; 25 : 9-13)


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