High-Resolution Twin-Ion Metabolite Extraction (HiTIME) Mass Spectrometry: Nontargeted Detection of Unknown Drug Metabolites by Isotope Labeling, Liquid Chromatography Mass Spectrometry, and Automated High-Performance Computing

Michael G. Leeming; Andrew P. Isaac; Bernard J. Pope; Noel Cranswick; Christine E. Wright; James Ziogas; Richard A. J. O’Hair; William A. Donald

doi:10.1021/ac504767d

High-Resolution Twin-Ion Metabolite Extraction (HiTIME) Mass Spectrometry: Nontargeted Detection of Unknown Drug Metabolites by Isotope Labeling, Liquid Chromatography Mass Spectrometry, and Automated High-Performance Computing

Analytical Chemistry ◽

10.1021/ac504767d ◽

2015 ◽

Vol 87 (8) ◽

pp. 4104-4109 ◽

Cited By ~ 19

Author(s):

Michael G. Leeming ◽

Andrew P. Isaac ◽

Bernard J. Pope ◽

Noel Cranswick ◽

Christine E. Wright ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

High Resolution ◽

High Performance Computing ◽

High Performance ◽

Isotope Labeling ◽

Liquid Chromatography Mass Spectrometry ◽

Drug Metabolites ◽

Performance Computing ◽

Metabolite Extraction

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Analysis of candidate anticancer drugs by thermospray high-performance liquid chromatography—mass spectrometry and by high-resolution mass spectrometry

Journal of Chromatography A ◽

10.1016/s0021-9673(01)95477-9 ◽

1985 ◽

Vol 347 ◽

pp. 137-146 ◽

Cited By ~ 16

Author(s):

Robert D. Voyksner ◽

Fred P. Williams ◽

John W. Hines

Keyword(s):

Mass Spectrometry ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

High Resolution ◽

Anticancer Drugs ◽

High Performance ◽

High Resolution Mass Spectrometry ◽

Liquid Chromatography Mass Spectrometry ◽

High Resolution Mass ◽

Resolution Mass

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High-Performance Chemical Isotope Labeling Liquid Chromatography–Mass Spectrometry for Profiling the Metabolomic Reprogramming Elicited by Ammonium Limitation in Yeast

Journal of Proteome Research ◽

10.1021/acs.jproteome.6b00070 ◽

2016 ◽

Vol 15 (5) ◽

pp. 1602-1612 ◽

Cited By ~ 14

Author(s):

Xian Luo ◽

Shuang Zhao ◽

Tao Huan ◽

Difei Sun ◽

R. Magnus N. Friis ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

High Performance ◽

Isotope Labeling ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry ◽

Chemical Isotope Labeling

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Investigation of the presence of endogenous prednisolone in equine urine by high-performance liquid chromatography mass spectrometry and high-resolution mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.6169 ◽

2012 ◽

Vol 26 (8) ◽

pp. 879-886 ◽

Cited By ~ 21

Author(s):

Marco Fidani ◽

Giuseppe Pompa ◽

Francesca Mungiguerra ◽

Alessio Casati ◽

Maria Letizia Fracchiolla ◽

...

Keyword(s):

Mass Spectrometry ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

High Resolution ◽

High Performance ◽

High Resolution Mass Spectrometry ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry ◽

High Resolution Mass ◽

Resolution Mass

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High-performance isotope-labeling liquid chromatography mass spectrometry for investigating the effect of drinking Goji tea on urine metabolome profiling

Science China Chemistry ◽

10.1007/s11426-014-5113-z ◽

2014 ◽

Vol 57 (5) ◽

pp. 678-685 ◽

Cited By ~ 6

Author(s):

Chiao-Li Tseng ◽

Liang Li

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

High Performance ◽

Isotope Labeling ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry ◽

Metabolome Profiling ◽

Urine Metabolome

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Determination of Pesticides in Apples by High-Performance Liquid Chromatography–Mass Spectrometry (HPLC–MS) with High-Resolution Multiple Reaction Monitoring

Analytical Letters ◽

10.1080/00032719.2021.1938594 ◽

2021 ◽

pp. 1-11

Author(s):

Feng-Qin Tu ◽

Ming Yang

Keyword(s):

Mass Spectrometry ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

High Resolution ◽

High Performance ◽

Multiple Reaction Monitoring ◽

Reaction Monitoring ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry

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THU0104 HIGH-PERFORMANCE CHEMICAL ISOTOPE LABELING LIQUID CHROMATOGRAPHY MASS SPECTROMETRY FOR DISCOVERY OF METABOLITE BIOMARKERS OF RHEUMATOID ARTHRITIS

10.1136/annrheumdis-2019-eular.4474 ◽

2019 ◽

Author(s):

Xiaohang Wang ◽

Joel Paschke ◽

Rana Dadashova ◽

Edna Hutchings ◽

LI Liang ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Mass Spectrometry ◽

Liquid Chromatography ◽

High Performance ◽

Isotope Labeling ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry ◽

Chemical Isotope Labeling

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High-Performance Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry for Exosome Metabolomics

Analytical Chemistry ◽

10.1021/acs.analchem.8b01726 ◽

2018 ◽

Vol 90 (14) ◽

pp. 8314-8319 ◽

Cited By ~ 24

Author(s):

Xian Luo ◽

Mingrui An ◽

Kyle C. Cuneo ◽

David M. Lubman ◽

Liang Li

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

High Performance ◽

Isotope Labeling ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry ◽

Chemical Isotope Labeling

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Rapid detection and quantification of aminoglycoside phosphorylation products using direct-infusion high-resolution and ultra-high-performance liquid chromatography/mass spectrometry

Rapid Communications in Mass Spectrometry ◽

10.1002/rcm.8241 ◽

2018 ◽

Vol 32 (20) ◽

pp. 1822-1828 ◽

Cited By ~ 2

Author(s):

Johnny J. Perez ◽

Chin-Yi Chen

Keyword(s):

Mass Spectrometry ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

High Resolution ◽

Rapid Detection ◽

High Performance ◽

Liquid Chromatography Mass Spectrometry ◽

Direct Infusion ◽

Chromatography Mass Spectrometry ◽

Detection And Quantification

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Analysis of ciprofloxacin in low- and high-fat milk by high-performance liquid chromatography-mass spectrometry

Acta Chromatographica ◽

10.1556/achrom.22.2010.1.9 ◽

2010 ◽

Vol 22 (1) ◽

pp. 117-131 ◽

Cited By ~ 1

Author(s):

K. Pápai ◽

M. Budai ◽

K. Ludányi ◽

I. Antal ◽

I. Klebovich

Keyword(s):

Mass Spectrometry ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

High Performance ◽

Liquid Chromatography Mass Spectrometry ◽

High Fat ◽

Chromatography Mass Spectrometry

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A NEW STRATEGY FOR PENTACHLOROPHENOL MONITORING IN WATER SAMPLES USING ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY - MASS SPECTROMETRY TANDEM

Environmental Engineering and Management Journal ◽

10.30638/eemj.2015.061 ◽

2015 ◽

Vol 14 (3) ◽

pp. 567-574 ◽

Cited By ~ 4

Author(s):

Lidia Favier ◽

Yassine Kadmi ◽

Maria Harja ◽

Andrei Ionut Simion ◽

Lacramioara Rusu ◽

...

Keyword(s):

Mass Spectrometry ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Water Samples ◽

High Performance ◽

Liquid Chromatography Mass Spectrometry ◽

Chromatography Mass Spectrometry ◽

New Strategy

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