Extending Mass Spectrometry Contribution to Therapeutic Monoclonal Antibody Lead Optimization: Characterization of Immune Complexes Using Noncovalent ESI-MS

2009 ◽  
Vol 81 (15) ◽  
pp. 6364-6373 ◽  
Author(s):  
Cédric Atmanene ◽  
Elsa Wagner-Rousset ◽  
Martine Malissard ◽  
Bertrand Chol ◽  
Alain Robert ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
Immune Complexes ◽  
Lead Optimization ◽  
Esi Ms ◽  
Therapeutic Monoclonal Antibody

Characterization of Drug-Product-Related Impurities and Variants of a Therapeutic Monoclonal Antibody by Higher Energy C-Trap Dissociation Mass Spectrometry

2015 ◽  
Vol 87 (2) ◽  
pp. 914-921 ◽  
Author(s):  
Deyun Wang ◽  
Colin Wynne ◽  
Flora Gu ◽  
Chris Becker ◽  
Jia Zhao ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
Drug Product ◽  
Therapeutic Monoclonal Antibody ◽  
Related Impurities

An improved capillary isoelectric focusing-mass spectrometry method for high-resolution characterization of monoclonal antibody charge variants

2022 ◽  
Author(s):  
Tian Xu ◽  
Linjie Han ◽  
Alayna M. George Thompson ◽  
Liangliang Sun
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
High Resolution ◽  
Isoelectric Focusing ◽  
Capillary Isoelectric Focusing ◽  
Spectrometry Method ◽  
Mass Spectrometry Method ◽  
Charge Variants

Routine and high-resolution characterization of monoclonal antibody (mAb) charge variants is vital for controlling mAb quality as therapeutics. Capillary isoelectric focusing-mass spectrometry (cIEF-MS) has emerged as a powerful tool for...

scholarly journals Detailed Characterization of Monoclonal Antibody Receptor Interaction Using Affinity Liquid Chromatography Hyphenated to Native Mass Spectrometry

2017 ◽  
Vol 89 (10) ◽  
pp. 5404-5412 ◽  
Author(s):  
Rabah Gahoual ◽  
Anna-Katharina Heidenreich ◽  
Govert W. Somsen ◽  
Patrick Bulau ◽  
Dietmar Reusch ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
Liquid Chromatography ◽  
Native Mass Spectrometry ◽  
Receptor Interaction ◽  
Detailed Characterization

The Application of Mass Spectrometry for the Characterization of Monoclonal Antibody-Based Therapeutics

2016 ◽  
pp. 351-385
Author(s):  
Rosie Upton ◽  
Kamila J. Pacholarz ◽  
David Firth ◽  
Sian Estdale ◽  
Perdita E. Barran
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody

scholarly journals Native Hydrophobic Interaction Chromatography Hyphenated to Mass Spectrometry for Characterization of Monoclonal Antibody Minor Variants

2019 ◽  
Vol 91 (24) ◽  
pp. 15360-15364 ◽  
Author(s):  
Bingchuan Wei ◽  
Guanghui Han ◽  
Jia Tang ◽  
Wendy Sandoval ◽  
Yonghua Taylor Zhang
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
Hydrophobic Interaction ◽  
Hydrophobic Interaction Chromatography

Characterization of the acidic species of a monoclonal antibody using free flow electrophoresis fractionation and mass spectrometry

2020 ◽  
Vol 185 ◽  
pp. 113217 ◽  
Author(s):  
Suli Liu ◽  
Seth Madren ◽  
Pamela Feng ◽  
Zoran Sosic
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
Free Flow

Characterization of Recombinant Monoclonal Antibody Charge Variants Using OFFGEL Fractionation, Weak Anion Exchange Chromatography, and Mass Spectrometry

2015 ◽  
Vol 87 (12) ◽  
pp. 6204-6211 ◽  
Author(s):  
Alyssa Neill ◽  
Christine Nowak ◽  
Rekha Patel ◽  
Gomathinayagam Ponniah ◽  
Nidia Gonzalez ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Monoclonal Antibody ◽  
Anion Exchange ◽  
Anion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Recombinant Monoclonal Antibody ◽  
Charge Variants ◽  
Weak Anion Exchange Chromatography
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