Comparative Analysis of Small-Molecule Diffusivity in Different Fat Crystal Network

2018 ◽  
Vol 66 (4) ◽  
pp. 1015-1022 ◽  
Author(s):  
Xiu hang Chai ◽  
Zong Meng ◽  
Pei rang Cao ◽  
Jiang Jiang ◽  
Yuan fa Liu
Keyword(s):  
Comparative Analysis ◽  
Small Molecule ◽  
Fat Crystal Network ◽  
Crystal Network

scholarly journals Identification of a conserved virion-stabilizing network inside the interprotomer pocket of enteroviruses

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Justin W. Flatt ◽  
Aušra Domanska ◽  
Alma L. Seppälä ◽  
Sarah J. Butcher
Keyword(s):  
Comparative Analysis ◽  
Drug Development ◽  
Ligand Binding ◽  
Small Molecule ◽  
Single Particle ◽  
Binding Pocket ◽  
Host Cells ◽  
Ligand Binding Pocket ◽  
Virus Attachment ◽  
Density Maps

AbstractEnteroviruses pose a persistent and widespread threat to human physical health, with no specific treatments available. Small molecule capsid binders have the potential to be developed as antivirals that prevent virus attachment and entry into host cells. To aid with broad-range drug development, we report here structures of coxsackieviruses B3 and B4 bound to different interprotomer-targeting capsid binders using single-particle cryo-EM. The EM density maps are beyond 3 Å resolution, providing detailed information about interactions in the ligand-binding pocket. Comparative analysis revealed the residues that form a conserved virion-stabilizing network at the interprotomer site, and showed the small molecule properties that allow anchoring in the pocket to inhibit virus disassembly.

Evolution of Fat Crystal Network Microstructure Followed by NMR

2011 ◽  
Vol 59 (5) ◽  
pp. 1767-1773 ◽  
Author(s):  
Matthieu Adam-Berret ◽  
Marine Boulard ◽  
Alain Riaublanc ◽  
François Mariette
Keyword(s):  
Fat Crystal Network ◽  
Crystal Network ◽  
Network Microstructure
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