scholarly journals StemCellCKB: An Integrated Stem Cell-Specific Chemogenomics KnowledgeBase for Target Identification and Systems-Pharmacology Research

2016 ◽  
Vol 56 (10) ◽  
pp. 1995-2004 ◽  
Author(s):  
Yu Zhang ◽  
Lirong Wang ◽  
Zhiwei Feng ◽  
Haizi Cheng ◽  
Terence Francis McGuire ◽  
...  
Keyword(s):  
Stem Cell ◽  
Target Identification ◽  
Systems Pharmacology ◽  
Integrated Stem

Integrated stem cells from apical papilla in a 3D culture system improve human embryonic stem cell derived retinal organoid formation

Life Sciences ◽  
2022 ◽  
pp. 120273
Author(s):  
Soraya Savoj ◽  
Mohammad Hossein Nasr Esfahani ◽  
Akbar Karimi ◽  
Fereshteh Karamali
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Culture System ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
3D Culture ◽  
Integrated Stem ◽  
3D Culture System ◽  
Apical Papilla

Pain-CKB, A Pain-Domain-Specific Chemogenomics Knowledgebase for Target Identification and Systems Pharmacology Research

2020 ◽  
Vol 60 (10) ◽  
pp. 4429-4435 ◽  
Author(s):  
Zhiwei Feng ◽  
Maozi Chen ◽  
Mingzhe Shen ◽  
Tianjian Liang ◽  
Hui Chen ◽  
...  
Keyword(s):  
Target Identification ◽  
Systems Pharmacology ◽  
Domain Specific ◽  
Pain Domain

Reconstitution of Human Peri-Implantation Embryogenesis With Integrated Stem Cell-Based Embryo Models

2021 ◽  
Author(s):  
Zongyong Ai ◽  
Baohua Niu ◽  
Yu Yin ◽  
Kui Duan ◽  
Lifeng Xiang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Integrated Stem

scholarly journals Chemogenomics knowledgebase and systems pharmacology for hallucinogen target identification—Salvinorin A as a case study

2016 ◽  
Vol 70 ◽  
pp. 284-295 ◽  
Author(s):  
Xiaomeng Xu ◽  
Shifan Ma ◽  
Zhiwei Feng ◽  
Guanxing Hu ◽  
Lirong Wang ◽  
...  
Keyword(s):  
Target Identification ◽  
Salvinorin A ◽  
Systems Pharmacology

Control of cancer stem cell like population by intracellular target identification followed by the treatment with peptide-siRNA complex

2017 ◽  
Vol 491 (3) ◽  
pp. 827-833 ◽  
Author(s):  
Jin Sook Suh ◽  
Hyun Jung Lee ◽  
Hyun Nam ◽  
Beom Soo Jo ◽  
Dong Woo Lee ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Target Identification ◽  
Intracellular Target

scholarly journals Target identification of mouse stem cell probe CDy1 as ALDH2 and Abcb1b through live-cell affinity-matrix and ABC CRISPRa library

2021 ◽  
Author(s):  
Naoki Miyamoto ◽  
Young-Hyun Go ◽  
Larissa Miasiro Ciaramicoli ◽  
Haw-Young Kwon ◽  
Heon Seok Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Embryonic Stem Cells ◽  
Target Identification ◽  
Embryonic Stem ◽  
Live Cell ◽  
Affinity Matrix ◽  
Regeneration Medicine ◽  
Cell Selectivity ◽  
Cell Affinity

CDy1 is a powerful tool to distingusih embryonic stem cells for reprogramming study and regeneration medicine. However, the stem cell selectivity mechanism of CDy1 has not been fully understood. Here,...

scholarly journals Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer’s Disease

2020 ◽  
Vol 21 (18) ◽  
pp. 6867 ◽  
Author(s):  
Juan Antonio Garcia-Leon ◽  
Laura Caceres-Palomo ◽  
Elisabeth Sanchez-Mejias ◽  
Marina Mejias-Ortega ◽  
Cristina Nuñez-Diaz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cell ◽  
Pluripotent Stem Cell ◽  
Complex Disease ◽  
Disease Modeling ◽  
Target Identification ◽  
Cell Types ◽  
Neural Cells ◽  
Human Pluripotent Stem Cell

Extracellular amyloid-beta deposition and intraneuronal Tau-laden neurofibrillary tangles are prime features of Alzheimer’s disease (AD). The pathology of AD is very complex and still not fully understood, since different neural cell types are involved in the disease. Although neuronal function is clearly deteriorated in AD patients, recently, an increasing number of evidences have pointed towards glial cell dysfunction as one of the main causative phenomena implicated in AD pathogenesis. The complex disease pathology together with the lack of reliable disease models have precluded the development of effective therapies able to counteract disease progression. The discovery and implementation of human pluripotent stem cell technology represents an important opportunity in this field, as this system allows the generation of patient-derived cells to be used for disease modeling and therapeutic target identification and as a platform to be employed in drug discovery programs. In this review, we discuss the current studies using human pluripotent stem cells focused on AD, providing convincing evidences that this system is an excellent opportunity to advance in the comprehension of AD pathology, which will be translated to the development of the still missing effective therapies.

Author response for "Inhibition of neural stem cell aging through the transient induction of reprogramming factors"

2020 ◽  
Author(s):  
Min Ji Han ◽  
Won Ji Lee ◽  
Joonhyuk Choi ◽  
Yean Ju Hong ◽  
Sang Jun Uhm ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Author Response ◽  
Cell Aging ◽  
Stem Cell Aging ◽  
Reprogramming Factors

The Response of Testes Cells to Low Level, Single dose Helium Particle Irradiation

1982 ◽  
Vol 40 ◽  
pp. 252-253
Author(s):  
D.E. Philpott ◽  
W. Sapp ◽  
C. Williams ◽  
J. Stevenson ◽  
S. Black ◽  
...  
Keyword(s):  
Stem Cell ◽  
Single Dose ◽  
B Cell ◽  
Cell Survival ◽  
Spermatogonial Stem Cell ◽  
Low Doses ◽  
Particle Irradiation ◽  
Stem Cell Survival ◽  
Irradiation Injury ◽  
Radio Sensitivity

Spermatogonial stem-cell survival after irradiation injury has been studied in rodents by histological counts of surviving cells. Many studies, including previous work from our laboratory, show that the spermatogonial population demonstrates a heterogeneous response to irradiation. The spermatogonia increase in radio-sensitivity as differentiation proceeds through the sequence As - Apr - A1 - A2 - A3 - A4 - In - B. The stem (As) cell is the most resistant and the B cell is the most sensitive. The purpose of this work is to investigate the response of spermatogonial cell to low doses (less than 10 0 rads) of helium particle irradiation.

Sign in / Sign up

Export Citation Format

Share Document