scholarly journals Polymeric Encapsulation of a Ru(II)-Based Photosensitizer for Folate-Targeted Photodynamic Therapy of Drug Resistant Cancers

2021 ◽  
Author(s):  
Johannes Karges ◽  
Mickaël Tharaud ◽  
Gilles Gasser
Keyword(s):  
Photodynamic Therapy ◽  
Drug Resistant ◽  
Targeted Photodynamic Therapy ◽  
Polymeric Encapsulation

scholarly journals Polymeric Encapsulation of a Ru(II)-based Photosensitizer for Folate Targeted Photodynamic Therapy of Drug Resistant Cancers

2020 ◽  
Author(s):  
Johannes Karges ◽  
Mickaël Tharaud ◽  
Gilles Gasser
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
High Selectivity ◽  
Drug Resistant ◽  
Multicellular Tumor Spheroids ◽  
Targeted Photodynamic Therapy ◽  
Polymeric Encapsulation ◽  
Cancerous Cells

<p>The currently used photodynamic therapy (PDT) photosensitizers (PSs) are generally associated with a poor cancer cell selectivity, which is responsible for some undesirable side effects. To overcome these problems, the use of selective drug delivery systems is currently envisioned. In this article, the encapsulation of a promising Ru(II) polypyridine complex-based PDT PS in a polymer with terminal folate groups to form nanoparticles is presented. While showing a high selectivity for cancerous cells over non-cancerous cells, the nanoparticles were found to be highly phototoxic in 2D monolayer cells as well as 3D multicellular tumor spheroids upon 480 nm or 595 nm irradiation. Promisingly, the nanoparticles were also active in drug resistant cancer cells lines, indicating that they are able to overcome drug resistances. <br></p>

scholarly journals Polymeric Encapsulation of a Ru(II)-based Photosensitizer for Folate Targeted Photodynamic Therapy of Drug Resistant Cancers

2020 ◽  
Author(s):  
Johannes Karges ◽  
Mickaël Tharaud ◽  
Gilles Gasser
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
High Selectivity ◽  
Drug Resistant ◽  
Multicellular Tumor Spheroids ◽  
Targeted Photodynamic Therapy ◽  
Polymeric Encapsulation ◽  
Cancerous Cells

<p>The currently used photodynamic therapy (PDT) photosensitizers (PSs) are generally associated with a poor cancer cell selectivity, which is responsible for some undesirable side effects. To overcome these problems, the use of selective drug delivery systems is currently envisioned. In this article, the encapsulation of a promising Ru(II) polypyridine complex-based PDT PS in a polymer with terminal folate groups to form nanoparticles is presented. While showing a high selectivity for cancerous cells over non-cancerous cells, the nanoparticles were found to be highly phototoxic in 2D monolayer cells as well as 3D multicellular tumor spheroids upon 480 nm or 595 nm irradiation. Promisingly, the nanoparticles were also active in drug resistant cancer cells lines, indicating that they are able to overcome drug resistances. <br></p>

Nanoceria-Mediated Drug Delivery for Targeted Photodynamic Therapy on Drug-Resistant Breast Cancer

2016 ◽  
Vol 8 (46) ◽  
pp. 31510-31523 ◽  
Author(s):  
Hong Li ◽  
Cong Liu ◽  
Yi-Ping Zeng ◽  
Yu-Hui Hao ◽  
Jia-Wei Huang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Drug Resistant ◽  
Targeted Photodynamic Therapy

Scavenger-Receptor Targeted Photodynamic Therapy¶

2000 ◽  
Vol 72 (4) ◽  
pp. 533 ◽  
Author(s):  
Michael R. Hamblin ◽  
Jaimie L. Miller ◽  
Bernhard Ortel
Keyword(s):  
Photodynamic Therapy ◽  
Scavenger Receptor ◽  
Targeted Photodynamic Therapy

scholarly journals Nanoscale Metal–Organic Layer Isolates Phthalocyanines for Efficient Mitochondria-Targeted Photodynamic Therapy

2021 ◽  
Vol 143 (5) ◽  
pp. 2194-2199 ◽  
Author(s):  
Geoffrey T. Nash ◽  
Taokun Luo ◽  
Guangxu Lan ◽  
Kaiyuan Ni ◽  
Michael Kaufmann ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Organic Layer ◽  
Metal Organic ◽  
Targeted Photodynamic Therapy
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