Polymeric Encapsulation of a Ru(II)-based Photosensitizer for Folate Targeted Photodynamic Therapy of Drug Resistant Cancers

10.26434/chemrxiv.13258613.v1 ◽

2020 ◽

Author(s):

Johannes Karges ◽

Mickaël Tharaud ◽

Gilles Gasser

Keyword(s):

Drug Delivery ◽

Photodynamic Therapy ◽

Side Effects ◽

Drug Delivery Systems ◽

High Selectivity ◽

Drug Resistant ◽

Multicellular Tumor Spheroids ◽

Targeted Photodynamic Therapy ◽

Polymeric Encapsulation ◽

Cancerous Cells

The currently used photodynamic therapy (PDT) photosensitizers (PSs) are generally associated with a poor cancer cell selectivity, which is responsible for some undesirable side effects. To overcome these problems, the use of selective drug delivery systems is currently envisioned. In this article, the encapsulation of a promising Ru(II) polypyridine complex-based PDT PS in a polymer with terminal folate groups to form nanoparticles is presented. While showing a high selectivity for cancerous cells over non-cancerous cells, the nanoparticles were found to be highly phototoxic in 2D monolayer cells as well as 3D multicellular tumor spheroids upon 480 nm or 595 nm irradiation. Promisingly, the nanoparticles were also active in drug resistant cancer cells lines, indicating that they are able to overcome drug resistances.

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Utilisation of Targeted Nanoparticle Photosensitiser Drug Delivery Systems for the Enhancement of Photodynamic Therapy

Molecules ◽

10.3390/molecules23102628 ◽

2018 ◽

Vol 23 (10) ◽

pp. 2628 ◽

Cited By ~ 17

Author(s):

Cherie Kruger ◽

Heidi Abrahamse

Keyword(s):

Drug Delivery ◽

Photodynamic Therapy ◽

Side Effects ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Tumour Cells ◽

Cancer Drug ◽

Ros Generation ◽

Poor Treatment ◽

Treatment Research

The cancer incidence world-wide has caused an increase in the demand for effective forms of treatment. One unconventional form of treatment for cancer is photodynamic therapy (PDT). PDT has 3 fundamental factors, namely a photosensitiser (PS) drug, light and oxygen. When a PS drug is administered to a patient, it can either passively or actively accumulate within a tumour site and once exposed to a specific wavelength of light, it is excited to produce reactive oxygen species (ROS), resulting in tumour destruction. However, the efficacy of ROS generation for tumour damage is highly dependent on the uptake of the PS in tumour cells. Thus, PS selective/targeted uptake and delivery in tumour cells is a crucial factor in PDT cancer drug absorption studies. Generally, within non-targeted drug delivery mechanisms, only minor amounts of PS are able to passively accumulate in tumour sites (due to the enhanced permeability and retention (EPR) effect) and the remainder distributes into healthy tissues, causing unwanted side effects and poor treatment prognosis. Thus, to improve the efficacy of PDT cancer treatment, research is currently focused on the development of specific receptor-based PS-nanocarrier platform drugs, which promote the active uptake and absorption of PS drugs in tumour sites only, avoiding unwanted side effects, as well as treatment enhancement. Therefore, the aim of this review paper is to focus on current actively targeted or passively delivered PS nanoparticle drug delivery systems, that have been previously investigated for the PDT treatment of cancer and so to deduce their overall efficacy and recent advancements.

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Targeted nanoparticles from xyloglucan–doxorubicin conjugate loaded with doxorubicin against drug resistance

RSC Advances ◽

10.1039/c6ra01779g ◽

2016 ◽

Vol 6 (31) ◽

pp. 26137-26146 ◽

Cited By ~ 6

Author(s):

Xuan Xie ◽

Shiying Luo ◽

Jean Felix Mukerabigwi ◽

Jian Mei ◽

Yuannian Zhang ◽

...

Keyword(s):

Drug Delivery ◽

Drug Resistance ◽

Side Effects ◽

Tumor Cells ◽

Cellular Uptake ◽

Drug Delivery Systems ◽

Drug Resistant ◽

The Novel ◽

Targeted Nanoparticles ◽

Nanoparticle Drug Delivery

The novel targeted Xyloglucan–doxorubicin nanoparticle drug delivery systems (DOX nano-DDSs) exhibited improved cellular uptake, increased accumulation in tumor, higher cytotoxicity against drug resistant tumor cells and reduced side effects.

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Nanoceria-Mediated Drug Delivery for Targeted Photodynamic Therapy on Drug-Resistant Breast Cancer

ACS Applied Materials & Interfaces ◽

10.1021/acsami.6b07338 ◽

2016 ◽

Vol 8 (46) ◽

pp. 31510-31523 ◽

Cited By ~ 45

Author(s):

Hong Li ◽

Cong Liu ◽

Yi-Ping Zeng ◽

Yu-Hui Hao ◽

Jia-Wei Huang ◽

...

Keyword(s):

Breast Cancer ◽

Drug Delivery ◽

Photodynamic Therapy ◽

Drug Resistant ◽

Targeted Photodynamic Therapy

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Polymeric Encapsulation of a Ru(II)-Based Photosensitizer for Folate-Targeted Photodynamic Therapy of Drug Resistant Cancers

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.0c02006 ◽

2021 ◽

Author(s):

Johannes Karges ◽

Mickaël Tharaud ◽

Gilles Gasser

Keyword(s):

Photodynamic Therapy ◽

Drug Resistant ◽

Targeted Photodynamic Therapy ◽

Polymeric Encapsulation

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Nanoparticle-based Drug Delivery Systems for Targeted Epigenetics Cancer Therapy

Current Drug Targets ◽

10.2174/1389450121666200514222900 ◽

2020 ◽

Vol 21 (11) ◽

pp. 1084-1098

Author(s):

Fengqian Chen ◽

Yunzhen Shi ◽

Jinming Zhang ◽

Qi Liu

Keyword(s):

Drug Delivery ◽

Side Effects ◽

Cancer Therapy ◽

Drug Delivery Systems ◽

Therapeutic Index ◽

Delivery Systems ◽

Epigenetic Therapy ◽

Cancer Therapies ◽

Therapeutic Benefits ◽

High Therapeutic Index

This review summarizes the epigenetic mechanisms of deoxyribonucleic acid (DNA) methylation, histone modifications in cancer and the epigenetic modifications in cancer therapy. Due to their undesired side effects, the use of epigenetic drugs as chemo-drugs in cancer therapies is limited. The drug delivery system opens a door for minimizing these side effects and achieving greater therapeutic benefits. The limitations of current epigenetic therapies in clinical cancer treatment and the advantages of using drug delivery systems for epigenetic agents are also discussed. Combining drug delivery systems with epigenetic therapy is a promising approach to reaching a high therapeutic index and minimizing the side effects.

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Hydrogels for modified-release drug delivery systems

Current Pharmaceutical Design ◽

10.2174/1381612828666211230114755 ◽

2021 ◽

Vol 28 ◽

Author(s):

Aleksandra Zielińska ◽

Piotr Eder ◽

Lucas Rannier ◽

Juliana C. Cardoso ◽

Patrícia Severino ◽

...

Keyword(s):

Drug Delivery ◽

Side Effects ◽

Drug Delivery Systems ◽

Search Strategy ◽

Delivery Systems ◽

Global Market ◽

Modified Release ◽

Safety And Efficacy ◽

Area Of Interest ◽

Release Drug

Abstract: Hydrogels for the modified-release drug delivery systems is a continuously growing area of interest for the pharmaceutical industry. According to the global market, the use of polymers in this area is projected to reach $31.4 million by 2027. This review discusses the recent advances and perspectives of hydrogel in drug delivery systems for oral, parenteral, nasal, topical, and ophthalmic. The search strategy did in January 2021, and it conducted an extensive database to identify studies published from January 2010 to December 2020.We described the main characteristic of the polymers to obtain an ideal hydrogel for a specific route of administration and the formulations that was a highlight in the literature. It concluded that the hydrogels are a set useful to decrease the number of doses, side effects, promote adhesion of patient and enhances the bioavailability of the drugs improving the safety and efficacy of the treatment.

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Acid‐sensitive reactive oxygen species triggered dual‐drug delivery systems for chemo‐photodynamic therapy to overcome multidrug resistance

Polymer International ◽

10.1002/pi.5997 ◽

2020 ◽

Vol 69 (7) ◽

pp. 619-626

Author(s):

Liping Yin ◽

Yanli Bao ◽

Lin Liu ◽

Jinze Wang ◽

Li Chen

Keyword(s):

Reactive Oxygen Species ◽

Drug Delivery ◽

Photodynamic Therapy ◽

Multidrug Resistance ◽

Drug Delivery Systems ◽

Reactive Oxygen ◽

Delivery Systems ◽

Oxygen Species ◽

Dual Drug

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Dual-sensitive dual-prodrug nanoparticles with light-controlled endo/lysosomal escape for synergistic photoactivated chemotherapy

Biomaterials Science ◽

10.1039/d1bm01154e ◽

2021 ◽

Author(s):

Yubin Huang ◽

Hongtong Lu ◽

Shasha He ◽

Qingfei Zhang ◽

Xiaoyuan Li ◽

...

Keyword(s):

Drug Delivery ◽

Side Effects ◽

Clinical Application ◽

Drug Delivery Systems ◽

Controlled Drug Delivery ◽

Delivery Systems ◽

Chemotherapeutic Agents

The clinical application of conventional chemotherapeutic agents, represented by cisplatin, is limited by severe side effects. So, it is essential to explore more safer and controlled drug delivery systems for...

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DRUG-RESISTANT TUBERCULOSIS: RECENT APPROACH IN POLYMER BASED NANOMEDICINE

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2016v8i10.11295 ◽

2016 ◽

Vol 8 (10) ◽

pp. 1 ◽

Cited By ~ 1

Author(s):

Jessy Shaji ◽

Mahmood Shaikh

Keyword(s):

Drug Delivery ◽

Side Effects ◽

Pulmonary Drug Delivery ◽

Symbiotic Association ◽

Drug Resistant ◽

Second Line ◽

Antitubercular Drugs ◽

Recent Approach ◽

Mdr Tb ◽

High Doses

Tuberculosis (TB) had been a leading chronic bacterial infection since decades. Current therapeutic management of Mycobacterium tuberculosis (MTB) is inadequate due to the lengthy course of treatment, drug-related side effects and ill-planned therapy, and these factors can lead to therapeutic failure and the emergence of drug-resistant TB. The Multi-drug-resistant (MDR) TB needs a lengthy course of treatment with second-line antitubercular drugs (ATDs) having higher side effects and cost. The misuse of second-line ATDs may result in extremely drug-resistant (XDR) strain which is very difficult to treat and require high doses of drugs resulting in more toxicity and side effects. This review highlights the need for novel drug delivery for the treatment of drug-susceptible and resistant TB. The characteristics of the nanoparticulate system in ATDs delivery and its approach in the MDR and XDR TB are discussed. The lung is the site of infection in pulmonary TB and the targeted drug delivery to the site of infection helps in achieving increased efficacy with less dose further reducing the side effects and toxicity. The symbiotic association of nanotechnology and pulmonary drug delivery give rise to an efficient inhalable polymer based nanoparticulate system containing ATDs for the better management of drug-susceptible and resistant TB. Various ATDs loaded polymer based nanocarrier systems like Alginate, PLGA, Chitosan and Gelatin nanocarriers are discussed in detail. Thus, this review highlights the current research in pulmonary drug delivery of polymer based ATDs nanomedicine and their importance in control of drug-resistant TB.

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