Enhanced Spacer Length between Mannose Mimicking Shikimoyl and Quinoyl Headgroups and Hydrophobic Region of Cationic Amphiphile Increases Efficiency of Dendritic Cell Based DNA Vaccination: A Structure–Activity Investigation

2017 ◽  
Vol 60 (4) ◽  
pp. 1605-1610 ◽  
Author(s):  
Chandrashekhar Voshavar ◽  
Rakesh C. R. Meka ◽  
Sanjoy Samanta ◽  
Srujan Marepally ◽  
Arabinda Chaudhuri
Keyword(s):  
Dendritic Cell ◽  
Dna Vaccination ◽  
Hydrophobic Region ◽  
Spacer Length ◽  
Structure Activity ◽  
Cationic Amphiphile

Cationic Amphiphile with Shikimic Acid Headgroup Shows More Systemic Promise Than Its Mannosyl Analogue as DNA Vaccine Carrier in Dendritic Cell Based Genetic Immunization

2010 ◽  
Vol 53 (3) ◽  
pp. 1387-1391 ◽  
Author(s):  
Ramishetti Srinivas ◽  
Priya P. Karmali ◽  
Dipankar Pramanik ◽  
Arup Garu ◽  
Yenugonda Venkata Mahidhar ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Dna Vaccine ◽  
Shikimic Acid ◽  
Genetic Immunization ◽  
Vaccine Carrier ◽  
Cationic Amphiphile

α-Tocopherol-anchored gemini lipids with delocalizable cationic head groups: Effect of spacer length on DNA compaction and transfection properties

2021 ◽  
Author(s):  
Mallikarjun Gosangi ◽  
Venkatesh Ravula ◽  
Hithavani Rapaka ◽  
Srilakshmi V Patri
Keyword(s):  
Gene Delivery ◽  
Cationic Lipids ◽  
Spacer Length ◽  
Dna Compaction ◽  
Structure Activity ◽  
Head Groups ◽  
Efficient Gene ◽  
Delivery Vehicles ◽  
Systematic Structure

Understanding the role of structural units in cationic lipids used for gene delivery is essential in designing efficient gene delivery vehicles. Herein we report a systematic structure-activity investigation on the...

Equivalent stimulation of naive and memory CD8 T cells by DNA vaccination: a dendritic cell‐dependent process

2009 ◽  
Vol 87 (3) ◽  
pp. 255-259 ◽  
Author(s):  
Sammy Bedoui ◽  
Gayle M Davey ◽  
Andrew M Lew ◽  
William R Heath
Keyword(s):  
T Cells ◽  
Dendritic Cell ◽  
Cd8 T Cells ◽  
Dna Vaccination ◽  
Memory Cd8 T Cells ◽  
Dependent Process ◽  
Stimulation Of

in silico Modeling of Curcumin Based Sulfonamides Inhibitors of the Human trans-Membrane Carbonic Anhydrase Isozyme, hCA IX by CoMSIA

2021 ◽  
Vol 6 (4) ◽  
pp. 306-309
Author(s):  
Sarvesh Datta Dixit ◽  
Shalini Singh
Keyword(s):  
Carbonic Anhydrase ◽  
Tumour Growth ◽  
Quantitative Structure Activity Relationship ◽  
Carbonic Anhydrases ◽  
Hydrophobic Region ◽  
Qsar Studies ◽  
Structure Activity ◽  
In Silico Modeling ◽  
Carbonic Anhydrase Isozyme ◽  
Field Similarity

Carbonic anhydrases, hCAs IX and XII are applied as the markers of progression of the disease in many oxygen deficient tumours and their specially manoeuvred inhibition is directly related to containing the growth of both primary tumours and tumour growth of secondary nature. Ligand-based quantitative structure-activity relationship (QSAR) studies were carried out on curcumin related, sulphonamide derivatives as inhibitors of human trans-membrane carbonic anhydrase isozyme, hCA IX by comparative molecular field similarity analysis (CoMSIA) implemented through the SYBYL package. The capacity of the model to predict coveted compound was evaluated using test set of three compounds. The best model created was found to be of choice as it showed a r2 value of 0.811 and a cross validated coefficient q2 value of 0.617 in tripos CoMSIA hydrophobic region. Results of the present study indicated that hydrophobic region factors play an important role in carbonic anhydrase hCA IX inhibition for compounds.

A long-lasting dendritic cell DNA vaccination system using lysinylated amphiphiles with mannose-mimicking head-groups

Biomaterials ◽  
2012 ◽  
Vol 33 (26) ◽  
pp. 6220-6229 ◽  
Author(s):  
Ramishetti Srinivas ◽  
Arup Garu ◽  
Gopikrishna Moku ◽  
Sachin B. Agawane ◽  
Arabinda Chaudhuri
Keyword(s):  
Dendritic Cell ◽  
Dna Vaccination ◽  
Head Groups

scholarly journals Strategy to Enhance Dendritic Cell‐Mediated DNA Vaccination in the Lung

2021 ◽  
Vol 4 (2) ◽  
pp. 2000228
Author(s):  
Yoo C. Kim ◽  
Henry T. Hsueh ◽  
Namho Kim ◽  
Jason Rodriguez ◽  
Kirby T. Leo ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Dna Vaccination

Strategy to Enhance Dendritic Cell‐Mediated DNA Vaccination in the Lung

2020 ◽  
Vol 3 (7) ◽  
pp. 2000013 ◽  
Author(s):  
Yoo C. Kim ◽  
Henry T. Hsueh ◽  
Namho Kim ◽  
Jason Rodriguez ◽  
Kirby T. Leo ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Dna Vaccination

Shikimoyl-ligand decorated gold nanoparticles for use in ex vivo engineered dendritic cell based DNA vaccination

Nanoscale ◽  
2019 ◽  
Vol 11 (16) ◽  
pp. 7931-7943 ◽  
Author(s):  
Rakeshchandra R. Meka ◽  
Sudip Mukherjee ◽  
Chitta Ranjan Patra ◽  
Arabinda Chaudhuri
Keyword(s):  
Gold Nanoparticles ◽  
Dendritic Cell ◽  
Ex Vivo ◽  
Dna Vaccination

Shikimoyl-ligand decorated AuNPs for ex vivo engineered DC based DNA vaccination.

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