in silico Modeling of Curcumin Based Sulfonamides Inhibitors of the Human trans-Membrane Carbonic Anhydrase Isozyme, hCA IX by CoMSIA

Carbonic anhydrases, hCAs IX and XII are applied as the markers of progression of the disease in many oxygen deficient tumours and their specially manoeuvred inhibition is directly related to containing the growth of both primary tumours and tumour growth of secondary nature. Ligand-based quantitative structure-activity relationship (QSAR) studies were carried out on curcumin related, sulphonamide derivatives as inhibitors of human trans-membrane carbonic anhydrase isozyme, hCA IX by comparative molecular field similarity analysis (CoMSIA) implemented through the SYBYL package. The capacity of the model to predict coveted compound was evaluated using test set of three compounds. The best model created was found to be of choice as it showed a r2 value of 0.811 and a cross validated coefficient q2 value of 0.617 in tripos CoMSIA hydrophobic region. Results of the present study indicated that hydrophobic region factors play an important role in carbonic anhydrase hCA IX inhibition for compounds.

Field Weights Computation for Probabilistic Record Linkage in Presence of Missing Data

Record linkage is the task for identifying which records refer to the same entity. When records in different data sources do not have a common key and they contain typographical errors in their identifier fields, the extended Fellegi–Sunter probabilistic record linkage method with consideration of field similarity proposed by Winkler, is one of the most effective methods to perform record linkage to our knowledge. But this method has a limitation that it cannot efficiently handle the problem of missing value in the fields, an inappropriate weight is assigned to record pair containing missing data. Therefore, to improve the performance of Winkler’s probabilistic record linkage method in presence of missing value, we proposed a solution for adjusting record pair’s weight when missing data occurred, which allows enhancing the accuracy of the Winkler’s record linkage decisions without increasing much more computational time.

DENSITY OF SEEDING, FIELD SIMILARITY AND STRUCTURE OF SPRING WHEAT CROP, DEPENDING ON VARIETY AND PRESEEP TREATMENT OF SEEDS

The article discusses the formation of planting density and spring wheat crop structure depending on varietal characteristics and seed dressing in the conditions of the Chuvash Republic. Varieties Margarita, Simbirtsit and Prokhorovka were studied. The second factor is seed treatment in three grades: 1. Without treatment (control). 2. Seed treatment with Benlat. 3. Seed treatment with Nano-Gro. The results of the analysis of the formation of field germination of seeds, the safety of plants and elements of the structure of the crop are presented. The effect of Nano-Gro in combination with the seed dresser Benlat was also studied. It has been shown that pre-sowing treatment of wheat seeds with Nano-Gro solution increases the formation of planting density, field germination and the structure of the spring wheat crop (Terekhov MB, 2000; Kodanev I.M., 1984; Makarova V.M., 1995; Shashkarov L.G., 2018; Tolstova S.L., 2018; Aleksandrova A.N. 2018). The formation of highly productive crops is influenced by field germination of seeds. At least 400-500 plants per 1 m2 should be considered the optimal density of seedlings of grain crops in the Chuvash Republic with a sowing rate of 6 million germinating grains per 1 ha, and field germination of 70-80% is achieved (Kodanev I.M., 1984). In our studies, the density of seedlings and field germination of seeds depended on both varietal characteristics and meteorological conditions that developed during the sowing - seedlings.

DENSITY OF SEEDING, FIELD SIMILARITY AND STRUCTURE OF SPRING WHEAT CROP, DEPENDING ON VARIETY AND PRESEEP TREATMENT OF SEEDS

The article discusses the formation of planting density and spring wheat crop structure depending on varietal characteristics and seed dressing in the conditions of the Chuvash Republic. Varieties Margarita, Simbirtsit and Prokhorovka were studied. The second factor is seed treatment in three grades: 1. Without treatment (control). 2. Seed treatment with Benlat. 3. Seed treatment with Nano-Gro. The results of the analysis of the formation of field germination of seeds, the safety of plants and elements of the structure of the crop are presented. The effect of Nano-Gro in combination with the seed dresser Benlat was also studied. It has been shown that pre-sowing treatment of wheat seeds with Nano-Gro solution increases the formation of planting density, field germination and the structure of the spring wheat crop (Terekhov MB, 2000; Kodanev I.M., 1984; Makarova V.M., 1995; Shashkarov L.G., 2018; Tolstova S.L., 2018; Aleksandrova A.N. 2018). The formation of highly productive crops is influenced by field germination of seeds. At least 400-500 plants per 1 m2 should be considered the optimal density of seedlings of grain crops in the Chuvash Republic with a sowing rate of 6 million germinating grains per 1 ha, and field germination of 70-80% is achieved (Kodanev I.M., 1984). In our studies, the density of seedlings and field germination of seeds depended on both varietal characteristics and meteorological conditions that developed during the sowing - seedlings.

Change of signs of fiber flax plants under the influence of different doses of gamma rays in M1

Peculiarities of the influence of different doses of gamma rays on the change in the morphophysiological and biological characteristics of flax plants have been revealed. It was determined that pre-sowing seed treatment with gamma rays negatively affects the field similarity and survival of plants during the growing season, which depend on both the dose of mutagen and the genotype. The following types of morphoses in M1 obtained: chlorophilic, stem and leaf structure, color, shape, seed size, shape, size of bolls and morphosis of sterility.

Формування урожайності нуту залежно від елементів інтенсифікації та добрив в умовах західного Лісостепу

Наведено результати досліджень щодо ефективності внесення засобів захисту рослин у технології вирощування нуту. Встановлено, що посіви нуту, на яких не використовували засоби захисту рослин, формували низьку врожайність (1,28 т/га) через сильне забур’янення та ураження рослин хворобами. Виявлено, що за внесення ґрунтового гербіциду «Рейсер КЕ» (флурохлоридон, 250 г/л), 2,5 л/га урожайність зросла до 2,30 т/га, або на 1,02 т/га. Використання інсектициду «Фастак», «К.Е.» (альфа-циперметрин, 100 г/л), 0,15 л/га не змінювало рівень урожайності. За триразової схеми внесення фунгіцидів «Рекс Дуо», «КС» (епоксиконазол, 187 г/л + тіофанат-метил, 310 г/л), 0,5 л/га у фазі початку бутонізації, «Абакус мк.е.» (піраклостробін, 62,5 г/л + епоксиконазол, 62,5 г/л ), 1,5 л/га у фазі цвітіння та «Фолікур 250 EW», «ЕВ» (тебуконазол, 250 г/л), 1,0 л/га у фазі наливу зерна урожайність зросла на 0,90 т/га порівняно з варіантом без фунгіцидів. У цілому в досліді завдяки використанню засобів захисту рослин урожайність зросла з 1,28 т/га до 3,21 т/га, тобто на 1,93 т/га (150,8 %). Урожайність нуту на варіанті без застосування добрив дорівнювала 2,42 т/га. Зі збільшенням норми фосфорних і калійних добрив врожайність підвищувалася на 0,18–0,67 т/га, або 7,4–27,7 %. Найвищу врожайність одержали на фоні Р40К60 + «Інтермаг бобові» + MgSO4 – 3,09 т/га. We presented the research results on the effectiveness of applying plant protection products and mineral fertilizers in the technology of chickpea growing. It was revealed that the chickpea had a low productivity (1.28 t/ha) on sowings where plant protection products were not applied due to significant growth of weeds and infections of chickpea plants. It was discovered that the chickpea’s productivity grew up to 2.30 t/ha, or by 1.02 t/ha, when the soil herbicide «Reiser» (flurochloridone, 250 g/l) was used in a concentration of 2.5 l/ha. Using of the insecticide «Fastak» (alpha-cypermethrin, 100 g/l) in a concentration of 0.15 l/ha had no effect on productivity. In case of the three-step application scheme of fungicides such as «Rex Duo» (epoxiconazole, 187 g/l + thiophanate-methyl, 310 g/l) in a concentration of 0.5 l/ha at the early phase of budding, «Abacus» (pyraclostrobin, 62.5 g/l + epoxiconazole, 62.5 g/l) in a concentration of 1.5 l/ha during flowering, and «Folikur» (tebuconazole, 250 g/l) in a concentration of 1.0 l/ha during seed filling, the productivity increased by 0.90 t/ha compared to the variant where fungicides were not applied. In total, due to the use of plant protection products in the experiment, the productivity increased from 1.28 t/ha to 3.21 t/ha, i.e. by 1.93 t/ha (150.8 %). Applying phosphorous and potassium fertilizers practically had no impact on field similarity and density of plants at the stage of seedling. When P40K60 + «Intermag legumes» + MgSO4 were used, the density of plants increased before harvesting to 7 plants per m2 compared to the variant without fertilizers. The productivity of the chickpea cultivar «Pamiat’» on the variant without applying fertilizers was 2.42 t/ha. When increasing the norms of phosphorous and potassium fertilizers, the productivity rose by 0.18–0.67 t/ha, or 7.4–27.7 %. Because of optimization of the system of use of fertilizers, the productivity increased from 2.42 t/ha on the variant without fertilizers to 3.09 t/ha on the variant where P40K60 + «Intermag legumes» + MgSO4 was used, i.e. increased by 0.67 t/ha.