Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-γ Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer

Jina Kim; Jaeyoung Song; Hyun Dong Ji; Eun Kyung Yoo; Jae-Eon Lee; Sang Bong Lee; Ji Min Oh; Seungmi Lee; Ji Sun Hwang; Heeseok Yoon; Dong-Su Kim; Su-Jeong Lee; Minseon Jeong; Sungwoo Lee; Kyung-Hee Kim; Hueng-Sik Choi; Sang Woo Lee; Keun-Gyu Park; In-Kyu Lee; Seong Heon Kim; Hayoung Hwang; Yong Hyun Jeon; Jungwook Chin; Sung Jin Cho

doi:10.1021/acs.jmedchem.8b01296

Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-γ Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.8b01296 ◽

2019 ◽

Vol 62 (4) ◽

pp. 1837-1858 ◽

Cited By ~ 6

Author(s):

Jina Kim ◽

Jaeyoung Song ◽

Hyun Dong Ji ◽

Eun Kyung Yoo ◽

Jae-Eon Lee ◽

...

Keyword(s):

Thyroid Cancer ◽

Sodium Iodide ◽

Anaplastic Thyroid Cancer ◽

Sodium Iodide Symporter ◽

Inverse Agonists ◽

Orally Bioavailable ◽

Estrogen Related Receptor

Download Full-text

Inverse Agonist of Estrogen-Related Receptor Enhances Sodium Iodide Symporter Function Through Mitogen-Activated Protein Kinase Signaling in Anaplastic Thyroid Cancer Cells

Journal of Nuclear Medicine ◽

10.2967/jnumed.115.160366 ◽

2015 ◽

Vol 56 (11) ◽

pp. 1690-1696 ◽

Cited By ~ 16

Author(s):

T. D. Singh ◽

S. Y. Jeong ◽

S.-W. Lee ◽

J.-H. Ha ◽

I.-K. Lee ◽

...

Keyword(s):

Thyroid Cancer ◽

Protein Kinase ◽

Sodium Iodide ◽

Anaplastic Thyroid Cancer ◽

Mitogen Activated Protein Kinase ◽

Sodium Iodide Symporter ◽

Mitogen Activated Protein ◽

Protein Kinase Signaling ◽

Thyroid Cancer Cells ◽

Estrogen Related Receptor

Download Full-text

Development of a novel orally active inverse agonist of estrogen-related receptor gamma (ERRγ), KH-NDTC as an enhancer for sodium iodide symporter: Its pharmacological effects in anaplastic thyroid cancer (ATC) in vitro and in vivo

Drug Metabolism and Pharmacokinetics ◽

10.1016/j.dmpk.2018.09.128 ◽

2019 ◽

Vol 34 (1) ◽

pp. S34

Author(s):

Yong Hyun Jeon ◽

Seon Hee Choi ◽

Sang Kyoon Kim

Keyword(s):

Thyroid Cancer ◽

Sodium Iodide ◽

Anaplastic Thyroid Cancer ◽

Inverse Agonist ◽

Pharmacological Effects ◽

Sodium Iodide Symporter ◽

Orally Active ◽

Estrogen Related Receptor

Download Full-text

A Novel Tyrosine Kinase Inhibitor Can Augment Radioactive Iodine Uptake Through Endogenous Sodium/Iodide Symporter Expression in Anaplastic Thyroid Cancer

Thyroid ◽

10.1089/thy.2018.0626 ◽

2020 ◽

Vol 30 (4) ◽

pp. 501-518 ◽

Cited By ~ 2

Author(s):

Ji Min Oh ◽

Se Hwan Baek ◽

Prakash Gangadaran ◽

Chae Moon Hong ◽

Ramya Lakshmi Rajendran ◽

...

Keyword(s):

Thyroid Cancer ◽

Tyrosine Kinase ◽

Tyrosine Kinase Inhibitor ◽

Sodium Iodide ◽

Radioactive Iodine ◽

Kinase Inhibitor ◽

Anaplastic Thyroid Cancer ◽

Iodine Uptake ◽

Sodium Iodide Symporter ◽

Radioactive Iodine Uptake

Download Full-text

Wild-type p53 enhances the cytotoxic effect of radionuclide gene therapy using sodium iodide symporter in a murine anaplastic thyroid cancer model

European Journal of Nuclear Medicine and Molecular Imaging ◽

10.1007/s00259-009-1251-5 ◽

2009 ◽

Vol 37 (2) ◽

pp. 235-241 ◽

Cited By ~ 8

Author(s):

Yong Jin Lee ◽

June-Key Chung ◽

Joo Hyun Kang ◽

Jae Min Jeong ◽

Dong Soo Lee ◽

...

Keyword(s):

Gene Therapy ◽

Thyroid Cancer ◽

Cytotoxic Effect ◽

Sodium Iodide ◽

Anaplastic Thyroid Cancer ◽

Sodium Iodide Symporter ◽

Cancer Model ◽

Wild Type ◽

Wild Type P53

Download Full-text

Biological implications of PTEN upregulation and altered sodium/iodide symporter intracellular distribution in resveratrol-suppressed anaplastic thyroid cancer cells

Journal of Cancer ◽

10.7150/jca.48180 ◽

2020 ◽

Vol 11 (23) ◽

pp. 6883-6891

Author(s):

Le Xiong ◽

Jun-Hua Nie ◽

Xiao-Min Lin ◽

Jian-Bin Wu ◽

Zhen Chen ◽

...

Keyword(s):

Thyroid Cancer ◽

Cancer Cells ◽

Sodium Iodide ◽

Anaplastic Thyroid Cancer ◽

Intracellular Distribution ◽

Sodium Iodide Symporter ◽

Thyroid Cancer Cells

Download Full-text

Preclinical efficacy of the oncolytic measles virus expressing the sodium iodide symporter in iodine non-avid anaplastic thyroid cancer: a novel therapeutic agent allowing noninvasive imaging and radioiodine therapy

Cancer Gene Therapy ◽

10.1038/cgt.2012.47 ◽

2012 ◽

Vol 19 (9) ◽

pp. 659-665 ◽

Cited By ~ 31

Author(s):

H V Reddi ◽

P Madde ◽

S J McDonough ◽

M A Trujillo ◽

J C Morris ◽

...

Keyword(s):

Thyroid Cancer ◽

Measles Virus ◽

Sodium Iodide ◽

Therapeutic Agent ◽

Radioiodine Therapy ◽

Noninvasive Imaging ◽

Anaplastic Thyroid Cancer ◽

Sodium Iodide Symporter ◽

Preclinical Efficacy ◽

Novel Therapeutic

Download Full-text

Histone Deacetylase Inhibition Affects Sodium Iodide Symporter Expression and Induces 131I Cytotoxicity in Anaplastic Thyroid Cancer Cells

Thyroid ◽

10.1089/thy.2012.0359 ◽

2013 ◽

Vol 23 (7) ◽

pp. 838-846 ◽

Cited By ~ 28

Author(s):

Mariateresa Pugliese ◽

Nicoletta Fortunati ◽

Antonina Germano ◽

Sofia Asioli ◽

Francesca Marano ◽

...

Keyword(s):

Thyroid Cancer ◽

Cancer Cells ◽

Histone Deacetylase ◽

Sodium Iodide ◽

Anaplastic Thyroid Cancer ◽

Sodium Iodide Symporter ◽

Histone Deacetylase Inhibition ◽

Thyroid Cancer Cells

Download Full-text

Histone Deacetylase Inhibitors Restore Radioiodide Uptake and Retention in Poorly Differentiated and Anaplastic Thyroid Cancer Cells by Expression of the Sodium/Iodide Symporter Thyroperoxidase and Thyroglobulin

Endocrinology ◽

10.1210/en.2003-1258 ◽

2004 ◽

Vol 145 (6) ◽

pp. 2865-2875 ◽

Cited By ~ 104

Author(s):

Fumihiko Furuya ◽

Hiroki Shimura ◽

Hideyo Suzuki ◽

Katsumi Taki ◽

Kazuyasu Ohta ◽

...

Keyword(s):

Thyroid Cancer ◽

Cancer Cells ◽

Histone Deacetylase ◽

Sodium Iodide ◽

Histone Deacetylase Inhibitors ◽

Anaplastic Thyroid Cancer ◽

Sodium Iodide Symporter ◽

Poorly Differentiated ◽

Thyroid Cancer Cells

Download Full-text

An investigation into sodium-iodide symporter (NIS) dimerization and its impact on radioiodide uptake in thyroid cancer

Endocrine Abstracts ◽

10.1530/endoabs.50.oc1.4 ◽

2017 ◽

Author(s):

Rebecca J. Thompson ◽

Alice Fletcher ◽

Hannah Nieto ◽

Mohammed Alshahrani ◽

Katie Baker ◽

...

Keyword(s):

Thyroid Cancer ◽

Sodium Iodide ◽

Sodium Iodide Symporter

Download Full-text

Faculty Opinions recommendation of The BRAFV600E oncogene induces transforming growth factor beta secretion leading to sodium iodide symporter repression and increased malignancy in thyroid cancer.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1168209.630442 ◽

2009 ◽

Author(s):

Giancarlo Vecchio ◽

Rosa Marina Melillo

Keyword(s):

Thyroid Cancer ◽

Growth Factor ◽

Transforming Growth Factor Beta ◽

Sodium Iodide ◽

Transforming Growth Factor ◽

Sodium Iodide Symporter ◽

Growth Factor Beta

Download Full-text