scholarly journals Merging Two Strategies for Mixed-Sequence Recognition of Double-Stranded DNA: Pseudocomplementary Invader Probes

2016 ◽  
Vol 81 (8) ◽  
pp. 3335-3346 ◽  
Author(s):  
Brooke A. Anderson ◽  
Patrick J. Hrdlicka
Keyword(s):  
Sequence Recognition ◽  
Double Stranded Dna ◽  
Mixed Sequence

scholarly journals Mixed-Sequence Recognition of Double-Stranded DNA Using Enzymatically Stable Phosphorothioate Invader Probes

Molecules ◽  
2015 ◽  
Vol 20 (8) ◽  
pp. 13780-13793 ◽  
Author(s):  
Brooke Anderson ◽  
Saswata Karmakar ◽  
Patrick Hrdlicka
Keyword(s):  
Sequence Recognition ◽  
Double Stranded Dna ◽  
Mixed Sequence

scholarly journals Identification and Characterization of Second-Generation Invader Locked Nucleic Acids (LNAs) for Mixed-Sequence Recognition of Double-Stranded DNA

2013 ◽  
Vol 78 (19) ◽  
pp. 9560-9570 ◽  
Author(s):  
Sujay P. Sau ◽  
Andreas S. Madsen ◽  
Peter Podbevsek ◽  
Nicolai K. Andersen ◽  
T. Santhosh Kumar ◽  
...  
Keyword(s):  
Nucleic Acids ◽  
Second Generation ◽  
Sequence Recognition ◽  
Double Stranded Dna ◽  
Mixed Sequence ◽  
Locked Nucleic Acids ◽  
Identification And Characterization

Selective recognition of G-quadruplexes by a dimeric carbocyanine dye

RSC Advances ◽  
2016 ◽  
Vol 6 (90) ◽  
pp. 87400-87404 ◽  
Author(s):  
P. Chilka ◽  
P. R. Patlolla ◽  
B. Datta
Keyword(s):  
Selective Recognition ◽  
Dna Molecules ◽  
Double Stranded Dna ◽  
Mixed Sequence ◽  
Carbocyanine Dye ◽  
G Quadruplex

A novel dimeric carbocyanine dye is found to recognise G-quadruplex structures selectively compared to mixed sequence or double-stranded DNA molecules.

scholarly journals Folding and duplex formation in mixed sequence recognition-encoded m-phenylene ethynylene polymers

2021 ◽  
Author(s):  
Giulia Iadevaia ◽  
Jonathan A. Swain ◽  
Diego Núñez-Villanueva ◽  
Andrew D. Bond ◽  
Christopher A. Hunter
Keyword(s):  
Phenylene Ethynylene ◽  
One Pot ◽  
Sequence Recognition ◽  
Mixed Sequence ◽  
Duplex Formation

One pot oligomerisation reactions give access to families of oligomers that allow facile analysis of folding propensity and assessment of suitability for sequence-selective duplex formation.

Targeting of mixed sequence double-stranded DNA using pyrene-functionalized 2′-amino-α-l-LNA

2005 ◽  
pp. 4279 ◽  
Author(s):  
Patrick J. Hrdlicka ◽  
T. Santhosh Kumar ◽  
Jesper Wengel
Keyword(s):  
Double Stranded Dna ◽  
Mixed Sequence

scholarly journals Impact of non-nucleotidic bulges on recognition of mixed-sequence dsDNA by pyrene-functionalized Invader probes

2020 ◽  
Vol 18 (24) ◽  
pp. 4645-4655
Author(s):  
Dale C. Guenther ◽  
Raymond G. Emehiser ◽  
Allison Inskeep ◽  
Saswata Karmakar ◽  
Patrick J. Hrdlicka
Keyword(s):  
Specific Recognition ◽  
Double Stranded Dna ◽  
Mixed Sequence

Invader probes featuring non-nucleotidic bulges are energetically activated for highly specific recognition of complementary double-stranded DNA targets.

scholarly journals Recognition of double-stranded DNA using energetically activated duplexes with interstrand zippers of 1-, 2- or 4-pyrenyl-functionalized O2′-alkylated RNA monomers

2014 ◽  
Vol 12 (39) ◽  
pp. 7758-7773 ◽  
Author(s):  
Saswata Karmakar ◽  
Andreas S. Madsen ◽  
Dale C. Guenther ◽  
Bradley C. Gibbons ◽  
Patrick J. Hrdlicka
Keyword(s):  
Single Nucleotide ◽  
Double Stranded Dna ◽  
Mixed Sequence

Energetically activated double-stranded probes with interstrand arrangements of intercalator-functionalized nucleotides enable recognition of mixed-sequence DNA with single nucleotide fidelity.

Head-to-head comparison of LNA, MPγPNA, INA and Invader probes targeting mixed-sequence double-stranded DNA

2020 ◽  
Vol 18 (1) ◽  
pp. 56-65 ◽  
Author(s):  
Raymond G. Emehiser ◽  
Eric Hall ◽  
Dale C. Guenther ◽  
Saswata Karmakar ◽  
Patrick J. Hrdlicka
Keyword(s):  
Specific Recognition ◽  
Double Stranded Dna ◽  
Mixed Sequence ◽  
Modified Dna ◽  
Dna Strands

Double-stranded (ds) Invader and INA probes allow for efficient and specific recognition of mixed-sequence dsDNA targets, whereas recognition is less efficient and specific with single-stranded LNA-modified DNA strands and fully modified MPγPNAs.

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