Enhanced Drug Loading in the Drug-in-Adhesive Transdermal Patch Utilizing a Drug–Ionic Liquid Strategy: Insight into the Role of Ionic Hydrogen Bonding

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DFT calculations reveal the viability of the two possible ion pair-hydrogen bonding and Brønsted acid-hydrogen bonding dual activation modes.


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The intra- and inter-hydrogen bonding networks that govern the catalytic activity of Brønsted acidic ionic liquids were identified.


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ChemInform ◽  
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Vol 33 (4) ◽  
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