scholarly journals Evaluation of Platensimycin and Platensimycin-Inspired Thioether Analogues against Methicillin-Resistant Staphylococcus aureus in Topical and Systemic Infection Mouse Models

2019 ◽  
Vol 16 (7) ◽  
pp. 3065-3071 ◽  
Author(s):  
Meng Su ◽  
Lin Qiu ◽  
Youchao Deng ◽  
Claudia H. Ruiz ◽  
Jeffrey D. Rudolf ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Mouse Models ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Systemic Infection ◽  
Methicillin Resistant

scholarly journals Plasma-Activated Saline Promotes Antibiotic Treatment of Systemic Methicillin-Resistant Staphylococcus aureus Infection

Antibiotics ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1018
Author(s):  
Lu Yang ◽  
Gulimire Niyazi ◽  
Yu Qi ◽  
Zhiqian Yao ◽  
Lingling Huang ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Combined Treatment ◽  
Atmospheric Pressure Plasma ◽  
Systemic Infection ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Methicillin Resistant ◽  
New Strategy ◽  
Hematological And Biochemical Parameters

Systemic infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are life-threatening due to their strong multidrug resistance, especially since the biofilms formed by MRSA are more difficult to inactivate by antibiotics, causing long term recurrence of infection. Plasma-activated saline (PAS), a derived form of cold atmospheric-pressure plasma, can effectively inactivate bacteria and cancer cells and has been applied to sterilization and cancer treatment. Previous studies have demonstrated that the pretreatment of MRSA with PAS could promote the action of antibiotics. Here, the PAS was used as an antibiotic adjuvant to promote the inactivation of MRSA biofilms by rifampicin and vancomycin, and the combined treatment reduced approximately 6.0-log10 MRSA cells in biofilms. The plasma-activated saline and rifampicin synergistically and effectively reduced the systemic infection in the murine model. The histochemical analysis and the blood hematological and biochemical test demonstrated that the combined treatment with plasma-activated saline and rifampicin improved the blood hematological and biochemical parameters of infected mice by reducing the infection. Therefore, PAS based on plasma technology represents a new strategy for the treatment of infectious disease caused by multidrug-resistant bacteria and alleviating antibiotic resistance.

Community-Acquired Methicillin-Resistant Staphylococcus Aureus Epidural Abscess With Bacteremia and Multiple Lung Abscesses: Case Report

2009 ◽  
Vol 18 (1) ◽  
pp. 86-88 ◽  
Author(s):  
Aaron S. Bruns ◽  
Namita Sood
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Distress Syndrome ◽  
Systemic Infection ◽  
Signs And Symptoms ◽  
Methicillin Resistant ◽  
History Of ◽  
Systemic Manifestations ◽  
Parenchymal Damage

A systemic infection due to community-acquired methicillin-resistant Staphylococcus aureus occurred in a hospital-naive 17-year-old girl with no history of soft-tissue infection. Although the initial signs and symptoms were indolent, systemic manifestations occurred, including extensive lung parenchymal damage and acute respiratory distress syndrome. The patient required long-term mechanical ventilation and was given linezolid for 8 weeks. Blood cultures eventually became negative for the staphylococci, and the patient was discharged to a rehabilitation facility. A probable source of the infection was the patient’s self-cutting and self-piercing.

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