Injectable Anti-inflammatory Nanofiber Hydrogel to Achieve Systemic Immunotherapy Post Local Administration

Nano Letters ◽  
2020 ◽  
Vol 20 (9) ◽  
pp. 6763-6773 ◽  
Author(s):  
Muchao Chen ◽  
Yanjun Tan ◽  
Ziliang Dong ◽  
Jiaqi Lu ◽  
Xiao Han ◽  
...  
Keyword(s):  
Local Administration ◽  
Anti Inflammatory ◽  
Systemic Immunotherapy

1997 William J. Stickel Silver Award. The anti-inflammatory action of locally injected ketorolac

1997 ◽  
Vol 87 (10) ◽  
pp. 460-465 ◽  
Author(s):  
JW Brook ◽  
A Boike ◽  
RL Zema ◽  
M Weaver ◽  
P Postak
Keyword(s):  
Single Dose ◽  
Inflammatory Process ◽  
Local Administration ◽  
Ketorolac Tromethamine ◽  
Control Groups ◽  
Inflammatory Conditions ◽  
Significant Difference ◽  
Anti Inflammatory ◽  
And Control ◽  
Inflammatory Action

Locally injected steroids are used to treat inflammatory conditions, in spite of the complications associated with their use. Ketorolac tromethamine, an injectable nonsteroidal anti-inflammatory drug, has not previously been evaluated for treatment of musculoskeletal inflammatory conditions via local administration. Eighty Achilles tendons of rabbits were traumatized in a controlled fashion. At the time of trauma, a single dose of ketorolac (1, 3, or 5 mg/kg) or normal saline was administered peritendinously. Three days later, the tendons were harvested and examined histologically to evaluate the degree of inflammation present in the tissue. No statistically significant difference was found between the experimental and control groups. The authors conclude that locally injected ketorolac does not prevent the onset of an inflammatory process.

Local administration of 4-Thiouridine, a novel molecule with potent anti-inflammatory properties, protects against experimental colitis and arthritis

2020 ◽  
Vol 85 ◽  
pp. 106598
Author(s):  
Manish Kumar Jeengar ◽  
Sudeep Chenna Narendra ◽  
Dinesh Thummuri ◽  
Mattias Magnusson ◽  
V.G.M. Naidu ◽  
...  
Keyword(s):  
Experimental Colitis ◽  
Local Administration ◽  
Anti Inflammatory

Development of New Delivery Strategies to Increase Bioavailability of Curcumin

1970 ◽  
Vol 1 (4) ◽  
pp. 335-340
Author(s):  
Guduri Viswanath ◽  
Aukunuru Jithan ◽  
VM Reddy
Keyword(s):  
Therapeutic Potential ◽  
Local Administration ◽  
Systemic Delivery ◽  
Liposomal Formulations ◽  
Ointment Formulation ◽  
Assay Methods ◽  
Delivery Strategies ◽  
Small Unilamellar Vesicles ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Cm) is a natural product which possesses antioxidant, anti-inflammatory and anti-tumor activities. Here, intravenous liposomes or transdermal ointment containing curcumin were formulated for stable systemic delivery of the drug. Intravenous small unilamellar vesicles were prepared using thin film-hydration technique followed by sonication while the ointment was prepared using a fusion technique. Transport across the mice skin was performed so as to select the optimum ointment formulation intended for systemic delivery. Both Pharmacokinetics and Pharmacodynamic (anti-inflammatory effect) studies were performed in rats with the selected ointment and liposomal formulations. The results indicated that both liposomal formulation and transdermal ointment after local administration were effective in achieving positive pharmacodynamic effects although drug levels are not be seen with the currently employed assay methods. The results suggest that both these delivery systems lead to very low systemic levels of the drugs. The present formulations provide improved systemic delivery of curcumin, which has therapeutic potential as an antioxidant and anti-inflammatory.

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