Technical Considerations for Scale-Up of Imine-Reductase-Catalyzed Reductive Amination: A Case Study

2019 ◽  
Vol 23 (6) ◽  
pp. 1262-1268 ◽  
Author(s):  
Amin Bornadel ◽  
Serena Bisagni ◽  
Ahir Pushpanath ◽  
Sarah L. Montgomery ◽  
Nicholas J. Turner ◽  
...  
Buildings ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 78
Author(s):  
Daria Uspenskaia ◽  
Karl Specht ◽  
Hendrik Kondziella ◽  
Thomas Bruckner

Without decarbonizing cities energy and climate objectives cannot be achieved as cities account for approximately two thirds of energy consumption and emissions. This goal of decarbonizing cities has to be facilitated by promoting net-zero/positive energy buildings and districts and replicating them, driving cities towards sustainability goals. Many projects in smart cities demonstrate novel and groundbreaking low-carbon solutions in demonstration and lighthouse projects. However, as the historical, geographic, political, social and economic context of urban areas vary greatly, it is not always easy to repeat the solution in another city or even district. It is therefore important to look for the opportunities to scale up or repeat successful pilots. The purpose of this paper is to explore common trends in technologies and replication strategies for positive energy buildings or districts in smart city projects, based on the practical experience from a case study in Leipzig—one of the lighthouse cities in the project SPARCS. One of the key findings the paper has proven is the necessity of a profound replication modelling to deepen the understanding of upscaling processes. Three models analyzed in this article are able to provide a multidimensional representation of the solution to be replicated.


2021 ◽  
Vol 11 (4) ◽  
pp. 1-54
Author(s):  
Mohammad Rishad Faridi ◽  
Saloni Sinha

Learning outcomes Appendix 1: Comic Frames A At the end of the case study discussion, students will able to as follows: Explain various growth strategies as a potential unicorn with the exponential growth mindset rather than linear growth mindset through adaptation of Massive Transformative Purpose (MTP) and Moonshot Thinking (MT). Demonstrate innovative and creative plans and ideas, with the ability to scale up in the circular economy. Review and summarize the power of Collaborative Innovation (CI). Compare and contrast different ways in dealing with Hedgehog and Fox style of leadership into the business. Appendix 2: Comic Frames B At the end of the case study discussion, students will able to as follows: Act with a growth strategy as a potential unicorn with the exponential growth mindset rather than linear growth mindset through adaptation of MTP and MT. Simulate innovative and creative plans and ideas, with the ability to scale up in the circular economy. Assess and leverage the power of CI. Decide and differentiate in dealing with Hedgehog and Fox style of leadership into the business. Case overview/synopsis Ankit Tripathi, was a compassionate 22-year-old, the typical lad from New Delhi, India, who seemed driven to change the world. His elder brother Atul Tripathi, a young, creative 25-year-old, was sat there next to him, beaming with pride and gratitude. Both brothers, being mechanical engineering graduates, had experienced the advancement of technology at the cost of Mother Earth. It pained them no end. It was the reason that Atul had refused to serve as an engineer in a government institution after graduating. The parents were shocked when Ankit followed suit. The brothers were poles apart in their personality and temperament, and it was rare to see them agree on anything in this way. Yet, they agreed to disagree with their parents and ventured into becoming entrepreneurs with a purpose and passion to salvage the environment. They had a vision, but without a proper roadmap, it would certainly be a tough game. Nevertheless, they boldly embarked upon their journey and established their start-up “Uneako” in 2019. “Uneako” was a calculated risk, taking into account family resistance (parents’ attitude/perception), personal conflicts (psychological), financial limitations (resources), shallow expertise (professionalism), social concern acceptability and low awareness (environment), government regulations (legalities/approvals), conflicts between brothers (personality issues), etc. Being from a nonbusiness family, the brothers had defied the wave of obstacles and challenges in daring to start their own business, putting at stake the hard-earned money of their father, Satendra Tripathi. Amidst so much social mockery, would Atul and Ankit succumb and become a laughing stock or would they find something that they could live and die for? Complexity Academic Level Appendix 1: Comic Frames A: This case has been particularly focused on undergraduate level students pursuing business or commerce programs. Especially those studying core courses, for example, entrepreneurial and strategic management. Appendix 2: Comic Frames B: This case has been particularly focused postgraduate-early stage or higher level students pursuing business or commerce programs. Particularly those specializing in entrepreneurial and strategic management courses. Also, can be taught in the entrepreneurial or start-up workshops. Supplementary materials www.pewresearch.org/topics/generation-z/ Paulynice. J.P., (2019) “From Idea to Reality: An Entrepreneur’s Guide to Meaningful Business Growth” Paulynice Consulting Group. Hardy.D., (2015) “The Entrepreneur Roller Coaster: It’s Your Turn to Join The Ride” Success Publishers. Wadhwa.V., Amla.I., Salkever.A., (2020) “From Incremental to Exponential” Berrett-Koehler Publishers. Sustainable Entrepreneurship: Business Success through Sustainability edited by Christina Weidinger, Franz Fischler, René Schmidpeter, Springer 2014. Teaching notes are available for educators only. Subject code CSS 3: Entrepreneurship.


2018 ◽  
Vol 16 (06) ◽  
pp. 1850052
Author(s):  
Y. H. Lee ◽  
M. Khalil-Hani ◽  
M. N. Marsono

While physical realization of practical large-scale quantum computers is still ongoing, theoretical research of quantum computing applications is facilitated on classical computing platforms through simulation and emulation methods. Nevertheless, the exponential increase in resource requirement with the increase in the number of qubits is an inherent issue in classical modeling of quantum systems. In the effort to alleviate the critical scalability issue in existing FPGA emulation works, a novel FPGA-based quantum circuit emulation framework based on Heisenberg representation is proposed in this paper. Unlike previous works that are restricted to the emulations of quantum circuits of small qubit sizes, the proposed FPGA emulation framework can scale-up to 120-qubit on Altera Stratix IV FPGA for the stabilizer circuit case study while providing notable speed-up over the equivalent simulation model.


2019 ◽  
Vol 18 ◽  
pp. 44
Author(s):  
Anita Cassidy

<p>In 2015 the City of Burlington developed a new 2015-2040 Strategic Plan: <em>Grow Bold, </em>which tasked Burlington Economic Development Corporation (BEDC) with supporting the start up and scale up of companies and making Burlington a start up destination. This article will outline the process that BEDC went through to better understand the local innovation ecosystem and the role that BEDC could play in supporting it. This process resulted in BEDC going from no role in supporting companies to start and grow to launching, TechPlace, Burlington’s new innovation Centre in 2017, which supported over 4,000 visitors in their entrepreneurial journey in year one of operations. </p><p><strong>Keywords: </strong>Innovation, Entrepreneurship, Startups, Job Creation, Startup Support, Innovation Centre</p>


2020 ◽  
Author(s):  
Xaver Neumeyer ◽  
Kathleen Foote ◽  
Robert Beichner ◽  
Melissa Dancy ◽  
Charles Henderson

Author(s):  
RAFFAELLA GUGLIELMANN ◽  
LILIANA IRONI

Fuzzy systems properly integrated with Qualitative Reasoning approaches yield a hybrid identification method, called FS-QM, that outperforms traditional data-driven approaches in terms of robustness, interpretability and efficiency in both rich and poor data contexts. This results from the embedment of the entire system dynamics predicted by the simulation of its qualitative model, represented by fuzzy-rules, into the fuzzy system. However, the intrinsic limitation of qualitative simulation to scale up to complex and large systems significantly reduces its efficient applicability to real-world problems. The novelty of this paper deals with a divide-and-conquer approach that aims at making qualitative simulation tractable and the derived behavioural description comprehensible and exhaustive, and consequently usable to perform system identification. The partition of the complete model into smaller ones prevents the generation of a complete temporal ordering of all unrelated events, that is one of the major causes of intractable branching in qualitative simulation. The set of generated behaviours is drastically but beneficially reduced as it still captures the entire range of possible dynamical distinctions. Thus, the properties of the correspondent fuzzy-rule base, that guarantee robustness and interpretability of the identified model, are preserved. The strategy we propose is discussed through a case study from the biological domain.


Catalysts ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1451
Author(s):  
Heyu Huo ◽  
Guangxiao Yao ◽  
Shizhen Wang

Chiral amines are key building blocks for pharmaceuticals. Economic assessment of commercial potential of bioprocesses is needed for guiding research. Biosynthesis of (S)-α-methylbenzylamine (MBA) was selected as case study. For transamination route, transaminase coupled with glucose dehydrogenase and lactate dehydrogenase catalyzed the reaction with NADH (Nicotinamide adenine dinucleotide) regeneration. Amine dehydrogenase coupled with NADH oxidase, which catalyzed the reductive amination process. Comparison of biosynthesis cost by reductive amination and transamination routes was carried out. Economic assessment based on the framework of cost analysis and preliminary process information revealed that cost is greatly dependent on enzyme price. The results indicated that enhancing the activity of amine dehydrogenase by 4–5 folds can drop the unit price of reductive amination to $0.5–0.6/g, which make it competitive with transamination route.


Author(s):  
Alan Barrell ◽  
Joanne Hsu

Shanghai Energy Corporation—SHEnergy Group, a major Chinese enterprise in energy provision and the development of continuous improvements in energy conservation within urban development, is undertaking a major initiative in establishing the Shanghai International Energy Innovation Centre (SIEIC). Within the programme, study visits to London and Cambridge in the UK led to a decision to seek close collaboration with established and mature centres of excellence in technology transfer and the support of new company development and scale up, providing the rapid transfer of methodology and process and in addition to establishing longer term connections and relationships enabling the identification, curation, funding and eventual adoption of promising new technology from Cambridgexf and other UK and Western centres by SIEIC—in ways bringing benefits to all parties.


2018 ◽  
Vol 36 (01) ◽  
pp. 013-018 ◽  
Author(s):  
Helen Skouteris ◽  
Angela Melder ◽  
Cate Bailey ◽  
Heather Morris ◽  
Rhonda Garad ◽  
...  

AbstractImplementation of healthcare guidelines, a set of recommendations aiming to optimize patient care, can be a complex process which is at risk of poor translation into practice. Failure to adopt new evidence-based healthcare findings can contribute to a large variation in care, potentially affecting outcomes for service users. Designed to avoid this issue, the Monash Centre for Health Research and Implementation (MCHRI) knowledge translation framework was created to support the development and future implementation of clinical practice guidelines. The framework is distinguished by a focus on methodological rigor, stakeholder engagement, and partnership, leading to the coproduction of a guideline and research projects. In this article, we use the development of the International Evidence-based Guideline on the Assessment and Management of Polycystic Ovarian Syndrome (2018) as a case study to articulate the MCHRI knowledge translation framework. Specifically, this article discusses stakeholder engagement; development and codesign of evidence-based recommendations; implementation and knowledge generation; dissemination, translation, and scale up; and refinement/learning from evaluation. This case study demonstrates how hybrid frameworks, models, and theories for implementation, such as the MCHRI implementation framework, have their place in healthcare. The underlying principle that informs the framework is stakeholder engagement, including codesign, empowerment, and partnership.


Author(s):  
Meagan Whisenant ◽  
Kathi Mooney

This case study reviews the evidence for adoption of concurrent palliative care (CPC) during treatment for advanced cancer. Increasing research evidence and expert panel consensus has resulted in national guidelines and professional society endorsement of early integration of palliative care into oncology care. However, there is variable uptake of these guidelines and penetration of CPC into practice. Barriers to implementation include the need to increase awareness of existing evidence and guidelines, stigma, adequacy of a workforce for scale-up, lack of models for integration and delivery, and restrictive reimbursement mechanisms. Changing health care models that emphasize value-based care over fee-for-service can accelerate adoption. Use of technology can also overcome barriers related to scalability and resource use. The case study concludes with the recommendation that implementation science methodologies be used to guide successful integration of CPC in outpatient and home-based settings for patients with advanced cancer and their family caregivers.


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