Role of Hairpin-Quadruplex DNA Secondary Structural Conversion in the Promoter of hnRNP K in Gene Transcriptional Regulation

2015 ◽  
Vol 17 (18) ◽  
pp. 4584-4587 ◽  
Author(s):  
Jun Qiu ◽  
Jinggong Liu ◽  
Shuobin Chen ◽  
Tian-Miao Ou ◽  
Jia-Heng Tan ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Structural Conversion ◽  
Quadruplex Dna ◽  
Hnrnp K ◽  
Gene Transcriptional Regulation

P3-119: Investigation of the role of tau gene transcriptional regulation in neurodegeneration

2011 ◽  
Vol 7 ◽  
pp. S552-S552
Author(s):  
Juan Anaya ◽  
Victoria Kay ◽  
Roberto Simone ◽  
Geshanthi Hondhamuni ◽  
Andrew Lees ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Gene Transcriptional Regulation

scholarly journals From cell membrane to the nucleus: an emerging role of E‐cadherin in gene transcriptional regulation

2014 ◽  
Vol 18 (9) ◽  
pp. 1712-1719 ◽  
Author(s):  
Wenjun Du ◽  
Xi Liu ◽  
Guiling Fan ◽  
Xingsheng Zhao ◽  
Yanying Sun ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Cell Membrane ◽  
Gene Transcriptional Regulation ◽  
E Cadherin

scholarly journals Modulation of transcriptional activity in brain lower grade glioma by alternative splicing

2018 ◽  
Author(s):  
Jin Li ◽  
Yang Wang ◽  
Xianglian Meng ◽  
Hong Liang
Keyword(s):  
Transcription Factor ◽  
Transcriptional Regulation ◽  
Alternative Splicing ◽  
Structural Features ◽  
Vital Role ◽  
Lower Grade ◽  
Exon Inclusion ◽  
Gene Transcriptional Regulation ◽  
Lower Grade Glioma

Proteins that modify the activity of transcription factor (TF), often called modulators, play a vital role in gene transcriptional regulation. Alternative splicing is a critical step of gene processing and it can modulate gene function by adding or removing certain protein domains, and therefore influences the activity of a protein. The objective of this study is to investigate the role of alternative splicing in modulating the transcriptional regulation in brain lower grade glioma (LGG), especially transcription factor ELK1, which is closely related to various diseases, including Alzheimer’s disease and down syndrome. Results showed that changes in the exon inclusion ratio of proteins APP and STK16 are associated with changes in the expression correlation between ELK1 and its targets. Meanwhile, the structural features of the two modulators are strongly associated with the pathological impact of exon inclusion. Our analysis suggests, protein in different splicing level could play different functions on transcription factors, hence induces multiple genes dysregulation.

scholarly journals Modulation of transcriptional activity in brain lower grade glioma by alternative splicing

2018 ◽  
Author(s):  
Jin Li ◽  
Yang Wang ◽  
Xianglian Meng ◽  
Hong Liang
Keyword(s):  
Transcription Factor ◽  
Transcriptional Regulation ◽  
Alternative Splicing ◽  
Structural Features ◽  
Vital Role ◽  
Lower Grade ◽  
Exon Inclusion ◽  
Gene Transcriptional Regulation ◽  
Lower Grade Glioma

Proteins that modify the activity of transcription factor (TF), often called modulators, play a vital role in gene transcriptional regulation. Alternative splicing is a critical step of gene processing and it can modulate gene function by adding or removing certain protein domains, and therefore influences the activity of a protein. The objective of this study is to investigate the role of alternative splicing in modulating the transcriptional regulation in brain lower grade glioma (LGG), especially transcription factor ELK1, which is closely related to various diseases, including Alzheimer’s disease and down syndrome. Results showed that changes in the exon inclusion ratio of proteins APP and STK16 are associated with changes in the expression correlation between ELK1 and its targets. Meanwhile, the structural features of the two modulators are strongly associated with the pathological impact of exon inclusion. Our analysis suggests, protein in different splicing level could play different functions on transcription factors, hence induces multiple genes dysregulation.

scholarly journals On the Role of Adenosine A2A Receptor Gene Transcriptional Regulation in Parkinson’s Disease

2019 ◽  
Vol 13 ◽  
Author(s):  
Anastasia Falconi ◽  
Alessandra Bonito-Oliva ◽  
Martina Di Bartolomeo ◽  
Marcella Massimini ◽  
Francesco Fattapposta ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Transcriptional Regulation ◽  
Receptor Gene ◽  
Adenosine A2a Receptor ◽  
Gene Transcriptional Regulation ◽  
A2a Receptor ◽  
Adenosine A2a

Emerging Role of G-quadruplex DNA as Target in Anticancer Therapy

2017 ◽  
Vol 22 (44) ◽  
pp. 6612-6624 ◽  
Author(s):  
Graziella Cimino-Reale ◽  
Nadia Zaffaroni ◽  
Marco Folini
Keyword(s):  
Anticancer Therapy ◽  
Quadruplex Dna ◽  
G Quadruplex

scholarly journals The Functional Role of Loops and Flanking Sequences of G-Quadruplex Aptamer to the Hemagglutinin of Influenza a Virus

2021 ◽  
Vol 22 (5) ◽  
pp. 2409
Author(s):  
Anastasia A. Bizyaeva ◽  
Dmitry A. Bunin ◽  
Valeria L. Moiseenko ◽  
Alexandra S. Gambaryan ◽  
Sonja Balk ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Core Structure ◽  
Dna Aptamer ◽  
Tertiary Structures ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Flanking Sequences ◽  
Related Proteins

Nucleic acid aptamers are generally accepted as promising elements for the specific and high-affinity binding of various biomolecules. It has been shown for a number of aptamers that the complexes with several related proteins may possess a similar affinity. An outstanding example is the G-quadruplex DNA aptamer RHA0385, which binds to the hemagglutinins of various influenza A virus strains. These hemagglutinins have homologous tertiary structures but moderate-to-low amino acid sequence identities. Here, the experiment was inverted, targeting the same protein using a set of related, parallel G-quadruplexes. The 5′- and 3′-flanking sequences of RHA0385 were truncated to yield parallel G-quadruplex with three propeller loops that were 7, 1, and 1 nucleotides in length. Next, a set of minimal, parallel G-quadruplexes with three single-nucleotide loops was tested. These G-quadruplexes were characterized both structurally and functionally. All parallel G-quadruplexes had affinities for both recombinant hemagglutinin and influenza virions. In summary, the parallel G-quadruplex represents a minimal core structure with functional activity that binds influenza A hemagglutinin. The flanking sequences and loops represent additional features that can be used to modulate the affinity. Thus, the RHA0385–hemagglutinin complex serves as an excellent example of the hypothesis of a core structure that is decorated with additional recognizing elements capable of improving the binding properties of the aptamer.

Sign in / Sign up

Export Citation Format

Share Document