Dual-Responsive Polyprodrug Nanoparticles with Cascade-Enhanced Magnetic Resonance Signals for Deep-Penetration Drug Release in Tumor Therapy

2020 ◽  
Vol 12 (44) ◽  
pp. 49489-49501
Author(s):  
Qiubo Hao ◽  
Zhixiong Wang ◽  
Wei Zhao ◽  
Liewei Wen ◽  
Wenhui Wang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Drug Release ◽  
Tumor Therapy ◽  
Deep Penetration ◽  
Dual Responsive

A charge-conversional intracellular-activated polymeric prodrug for tumor therapy

2016 ◽  
Vol 7 (12) ◽  
pp. 2253-2263 ◽  
Author(s):  
Yue Wang ◽  
Shixian Lv ◽  
Mingxiao Deng ◽  
Zhaohui Tang ◽  
Xuesi Chen
Keyword(s):  
Drug Release ◽  
Tumor Therapy ◽  
Circulation Time ◽  
Cellular Internalization ◽  
Dual Responsive ◽  
Polymeric Prodrug ◽  
Responsive Polymer ◽  
A Charge

A pH and redox dual responsive polymer–PTX conjugate with a prolonged circulation time, enhanced cellular internalization and timely intracellular drug release, is reported.

Tailor-made legumain/pH dual-responsive doxorubicin prodrug-embedded nanoparticles for efficient anticancer drug delivery and in situ monitoring of drug release

Nanoscale ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 2673-2685 ◽  
Author(s):  
Yang Li ◽  
Yimin Niu ◽  
Jianhua Zhu ◽  
Cuicui Gao ◽  
Qunwei Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Stromal Cells ◽  
Tumor Therapy ◽  
In Situ Monitoring ◽  
Anticancer Drug Delivery ◽  
Dual Responsive ◽  
Lysosomal Cysteine Protease ◽  
Embedded Nanoparticles

Legumain enzyme is a well-conserved lysosomal cysteine protease that is overexpressed in many tumor cells and tumor stromal cells. Herein, we developed a legumain/pH double-sensitive nanosystem for targeted tumor therapy.

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

Primary Macrophage-Based Microrobots: An Effective Tumor Therapy In Vivo by Dual-Targeting Function and Near-Infrared-Triggered Drug Release

ACS Nano ◽  
2021 ◽  
Author(s):  
Van Du Nguyen ◽  
Hyun-Ki Min ◽  
Ho Yong Kim ◽  
Jiwon Han ◽  
You Hee Choi ◽  
...  
Keyword(s):  
Drug Release ◽  
Near Infrared ◽  
Tumor Therapy ◽  
Primary Macrophage ◽  
Dual Targeting ◽  
Triggered Drug Release

A Smart Glutathione and H2O2 Dual-Responsive Signal Inversion Magnetic Resonance Imaging Contrast Agent for Tumor Diagnosis

2021 ◽  
Vol 49 (8) ◽  
pp. e21141-e21150
Author(s):  
Zi-Hou LI ◽  
Kun QIAN ◽  
Akakuru Ozioma-Udochukwu ◽  
Chun-Shu PAN ◽  
Xue-Hua MA ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Tumor Diagnosis ◽  
Resonance Imaging ◽  
Dual Responsive ◽  
Magnetic Resonance Imaging Contrast ◽  
Imaging Contrast Agent ◽  
Signal Inversion

scholarly journals Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

2018 ◽  
Vol 115 (3) ◽  
pp. 501-506 ◽  
Author(s):  
Meng Qiu ◽  
Dou Wang ◽  
Weiyuan Liang ◽  
Liping Liu ◽  
Yin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Black Phosphorus ◽  
Deep Penetration ◽  
Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

Folate-conjugated dually responsive micelles for targeted anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (42) ◽  
pp. 35658-35667 ◽  
Author(s):  
Lingling Zhao ◽  
Yajuan Zhang ◽  
Jia Shao ◽  
Hongze Liang ◽  
Haining Na ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Anticancer Activity ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Dual Responsive

Folate-conjugated dual-responsive micelles were developed, sustained and sensitive drug release from the drug loaded micelles was observed. Folate-targeted micelles showed higher anticancer activity and enhanced cellar uptake than non-targeted ones.

A porous Zn-based metal-organic framework for pH and temperature dual-responsive controlled drug release

2017 ◽  
Vol 249 ◽  
pp. 55-60 ◽  
Author(s):  
Wenxin Lin ◽  
Quan Hu ◽  
Ke Jiang ◽  
Yuanjing Cui ◽  
Yu Yang ◽  
...  
Keyword(s):  
Drug Release ◽  
Metal Organic Framework ◽  
Controlled Drug Release ◽  
Dual Responsive ◽  
Metal Organic ◽  
Organic Framework

scholarly journals A pH and magnetic dual-response hydrogel for synergistic chemo-magnetic hyperthermia tumor therapy

RSC Advances ◽  
2018 ◽  
Vol 8 (18) ◽  
pp. 9812-9821 ◽  
Author(s):  
Xiaohan Zhou ◽  
Longchen Wang ◽  
Yanjun Xu ◽  
Wenxian Du ◽  
Xiaojun Cai ◽  
...  
Keyword(s):  
Tumor Therapy ◽  
Magnetic Hyperthermia ◽  
Dual Responsive ◽  
Dual Response ◽  
Highly Sensitive

A pH and magnetic dual-responsive hydrogel highly sensitive to tumor acid microenvironment and efficient responsive magnetic-hyperthermia cancer eradication.

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