Acid-Induced Activated Cell-Penetrating Peptide-Modified Cholesterol-Conjugated Polyoxyethylene Sorbitol Oleate Mixed Micelles for pH-Triggered Drug Release and Efficient Brain Tumor Targeting Based on a Charge Reversal Mechanism

2018 ◽  
Vol 10 (50) ◽  
pp. 43411-43428 ◽  
Author(s):  
Yu Tian ◽  
Gujie Mi ◽  
Qian Chen ◽  
Birendra Chaurasiya ◽  
Yanan Li ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Drug Release ◽  
Tumor Targeting ◽  
Mixed Micelles ◽  
Cell Penetrating Peptide ◽  
Charge Reversal ◽  
Cell Penetrating ◽  
Reversal Mechanism ◽  
Triggered Drug Release ◽  
A Charge

scholarly journals Tumor targeting of a cell penetrating peptide by fusing with a pH-sensitive histidine-glutamate co-oligopeptide

Biomaterials ◽  
2014 ◽  
Vol 35 (13) ◽  
pp. 4082-4087 ◽  
Author(s):  
Likun Fei ◽  
Li-Peng Yap ◽  
Peter S. Conti ◽  
Wei-Chiang Shen ◽  
Jennica L. Zaro
Keyword(s):  
Tumor Targeting ◽  
Ph Sensitive ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
A Cell

Novel Brain-Tumor-Inhibiting Copper(II) Compound Based on a Human Serum Albumin (HSA)-Cell Penetrating Peptide Conjugate

2019 ◽  
Vol 62 (23) ◽  
pp. 10630-10644 ◽  
Author(s):  
Zhenlei Zhang ◽  
Ping Yu ◽  
Yi Gou ◽  
Juzheng Zhang ◽  
Shanhe Li ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating

A multifunctional PEG–PLL drug conjugate forming redox-responsive nanoparticles for intracellular drug delivery

2015 ◽  
Vol 3 (38) ◽  
pp. 7594-7603 ◽  
Author(s):  
Zhuxian Zhou ◽  
Jianbin Tang ◽  
Qihang Sun ◽  
William J. Murdoch ◽  
Youqing Shen
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Tumor Targeting ◽  
High Stability ◽  
Cancer Targeting ◽  
Drug Conjugate ◽  
Intracellular Drug Delivery ◽  
Redox Responsive ◽  
Triggered Drug Release

Tumor-targeting camptothecin (CPT)-conjugated nanoparticles with high stability and GSH-triggered drug release were developed for cancer targeting drug delivery.

scholarly journals Pharmacodynamics of siRNARANKL and Oestrogen Loaded MSNs-CADY on Human Periodontal Ligament Stem Cells with Porphyromonas gingivalis infection

2020 ◽  
Author(s):  
Liang Song ◽  
Xiaojun Shi ◽  
Fengling Hu ◽  
Huijuan Chen ◽  
Bin Xu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Porphyromonas Gingivalis ◽  
Periodontal Ligament ◽  
Mesoporous Silica Nanoparticles ◽  
Cell Penetrating Peptide ◽  
Periodontal Ligament Stem Cells ◽  
Cell Penetrating

Abstract Background: Periodontitis irreversibly invades and destroys periodontal supporting tissues, loses the ability of periodontal regeneration and restoration, and eventually leads to tooth loosening and loss. periodontal ligament stem cells (PDLSCs) hold great promises for periodontal tissue regeneration which was the potential target of periodontitis treatment, siRNARANKL and oestrogen can help PDLSCs maintain normal function, however, it was very difficult for siRNARANKL and oestrogen to get into PDLSCs. Here, Cell penetrating peptide CADY was modified on the surface of siRNARANKL and oestrogen loaded mesoporous silica nanoparticles (MSNs) to carry them into Porphyromonas gingivalis infected PDLSCs, Then further affect the proliferation of PDLSCs. Methods: 120-150 nm Mesoporous silica nanoparticles (MSNs) was prepared, and the biocompatibility, loading capacity and drug release properity were tested; MSNs was modified by penetrating peptide CADY and the prepared MSNs/CADY was loaded with siRNARANKL and oestrogen; In vitro drug release of siRNARANKL/MSNs-CADY and oestrogen/MSNs-CADY was tested by using semi-permeable dialysis bag diffusion; Cellular uptake and internalization of FITC-Labeled MSNs and FITC-Labeled MSNs-CADY was observed by use of Laser confocal microscopy; Finally, the effect of siRNARANKL and oestrogen loaded MSNs-CADY on cell proliferation of Porphyromonas gingivalis infected human periodontal ligament stem cells was tested by MTT assay. Results: according to the results, MSNs-CADY with a concentration of 6.25-200 ug/mL have no toxic to PDLSCs; 24.6 mg oestrogen and 0.5 mM siRNARANKL can be loaded into 1mg of MSNs-CADY; and drug loaded MSNs-CADY nanodrug carriers can release siRNARANKL and oestrogen stably for at least 48 h; After modification with cell penetrating peptide CADY, more MSNs-CADY can be taken by PDLSCs. siRNARANKL/oestrogen/MSNs-CADY can increase the proliferation of PDLSCs significantly. Conclusion: siRNARANKL/oestrogen/MSNs-CADY constructed can significantly improve the cell proliferation of P-gingivalis infected PDLSCs, this nano drug carrier has the potential to be used in PDLSCs -based periodontitis treatment, this work provided a useful theoretical basis and therapeutic ideas for the treatment of periodontitis.

Tumor homing cell penetrating peptide decorated nanoparticles used for enhancing tumor targeting delivery and therapy

2015 ◽  
Vol 478 (1) ◽  
pp. 240-250 ◽  
Author(s):  
Huile Gao ◽  
Qianyu Zhang ◽  
Yuting Yang ◽  
Xinguo Jiang ◽  
Qin He
Keyword(s):  
Tumor Targeting ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
Targeting Delivery ◽  
Tumor Homing

Novel pH-sensitive charge-reversal cell penetrating peptide conjugated PEG-PLA micelles for docetaxel delivery: In vitro study

2014 ◽  
Vol 466 (1-2) ◽  
pp. 233-245 ◽  
Author(s):  
Ammar Ouahab ◽  
Nihad Cheraga ◽  
Vitus Onoja ◽  
Yan Shen ◽  
Jiasheng Tu
Keyword(s):  
In Vitro Study ◽  
Ph Sensitive ◽  
Vitro Study ◽  
Cell Penetrating Peptide ◽  
Charge Reversal ◽  
Cell Penetrating

Locked Nucleic Acid Nanomicelle with Cell-Penetrating Peptides for Glutathione-Triggered Drug Release and Cell Fluorescence Imaging

2018 ◽  
Vol 2 (1) ◽  
pp. 370-377 ◽  
Author(s):  
Xiaoting Ji ◽  
Ruiyuan Zhang ◽  
Zhenbo Wang ◽  
Shuyan Niu ◽  
Caifeng Ding
Keyword(s):  
Nucleic Acid ◽  
Drug Release ◽  
Fluorescence Imaging ◽  
Cell Penetrating Peptides ◽  
Locked Nucleic Acid ◽  
Cell Penetrating ◽  
Triggered Drug Release

Thermo, pH and reduction responsive coaggregates comprising AB2C2 star terpolymers for multi-triggered release of doxorubicin

2014 ◽  
Vol 5 (10) ◽  
pp. 3335-3345 ◽  
Author(s):  
Ke Miao ◽  
Huanhuan Liu ◽  
Youliang Zhao
Keyword(s):  
Drug Release ◽  
Mixed Micelles ◽  
Triggered Release ◽  
Triggered Drug Release

Novel disulfide-linked PEG(PCL)2(PNIPAM)2 and PEG(PCL)2(PAA)2 star terpolymers were synthesized and coassembled into mixed micelles or vesicles for multi-triggered drug release.

scholarly journals A detachable coating of cholesterol-anchored PEG improves tumor targeting of cell-penetrating peptide-modified liposomes

2014 ◽  
Vol 4 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Jie Tang ◽  
Li Zhang ◽  
Han Fu ◽  
Qifang Kuang ◽  
Huile Gao ◽  
...  
Keyword(s):  
Tumor Targeting ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating
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