scholarly journals Hybrid Nanoparticle Platform for Nanoscale Scintillation Proximity Assay

2019 ◽  
Vol 2 (3) ◽  
pp. 1259-1266
Author(s):  
Colleen M. Janczak ◽  
Isen A.C. Calderon ◽  
Eka Noviana ◽  
Priyanka Hadvani ◽  
Joo Ryung Lee ◽  
...  
Keyword(s):  
Scintillation Proximity Assay ◽  
Hybrid Nanoparticle

Hybrid nanoparticle based fluorescence switch for recognition of ketoprofen in aqueous media

2020 ◽  
Vol 5 (8) ◽  
pp. 1428-1436
Author(s):  
Anu Saini ◽  
Manpreet Kaur ◽  
Mayank ◽  
Anil Kuwar ◽  
Navneet Kaur ◽  
...  
Keyword(s):  
Aqueous Media ◽  
Fluorescent Chemosensors ◽  
Fluorescence Switch ◽  
Nanomolar Detection ◽  
Hybrid Nanoparticle

Hybrid nanoassembly, fluorescent chemosensors, selective response to ketoprofen, and nanomolar detection.

scholarly journals Self-assembling ferritin-dendrimer nanoparticles for targeted delivery of nucleic acids to myeloid leukemia cells

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Federica Palombarini ◽  
Silvia Masciarelli ◽  
Alessio Incocciati ◽  
Francesca Liccardo ◽  
Elisa Di Fabio ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Targeted Delivery ◽  
Myeloid Leukemia ◽  
Electrostatic Interactions ◽  
Archaeoglobus Fulgidus ◽  
Leukemia Cells ◽  
Cellular Delivery ◽  
Self Assembling ◽  
Wide Range ◽  
Hybrid Nanoparticle

Abstract Background In recent years, the use of ferritins as nano-vehicles for drug delivery is taking center stage. Compared to other similar nanocarriers, Archaeoglobus fulgidus ferritin is particularly interesting due to its unique ability to assemble-disassemble under very mild conditions. Recently this ferritin was engineered to get a chimeric protein targeted to human CD71 receptor, typically overexpressed in cancer cells. Results Archaeoglobus fulgidus chimeric ferritin was used to generate a self-assembling hybrid nanoparticle hosting an aminic dendrimer together with a small nucleic acid. The positively charged dendrimer can indeed establish electrostatic interactions with the chimeric ferritin internal surface, allowing the formation of a protein-dendrimer binary system. The 4 large triangular openings on the ferritin shell represent a gate for negatively charged small RNAs, which access the internal cavity attracted by the dense positive charge of the dendrimer. This ternary protein-dendrimer-RNA system is efficiently uptaken by acute myeloid leukemia cells, typically difficult to transfect. As a proof of concept, we used a microRNA whose cellular delivery and induced phenotypic effects can be easily detected. In this article we have demonstrated that this hybrid nanoparticle successfully delivers a pre-miRNA to leukemia cells. Once delivered, the nucleic acid is released into the cytosol and processed to mature miRNA, thus eliciting phenotypic effects and morphological changes similar to the initial stages of granulocyte differentiation. Conclusion The results here presented pave the way for the design of a new family of protein-based transfecting agents that can specifically target a wide range of diseased cells. Graphic abstract

Novel application of graphite-talc hybrid nanoparticle enriched cutting fluid in turning operation

2021 ◽  
Vol 62 ◽  
pp. 378-387
Author(s):  
Vaibhav Singh ◽  
Anuj Kumar Sharma ◽  
Ranjeet Kumar Sahu ◽  
Jitendra Kumar Katiyar
Keyword(s):  
Cutting Fluid ◽  
Turning Operation ◽  
Hybrid Nanoparticle

Numerically simulated behavior of radiative Fe3O4 and multi-walled carbon nanotube hybrid nanoparticle flow in presence of Lorentz force

2021 ◽  
Vol 42 (3) ◽  
pp. 347-356
Author(s):  
S. A. Shehzad ◽  
M. Sheikholeslami ◽  
T. Ambreen ◽  
A. Saleem ◽  
A. Shafee
Keyword(s):  
Carbon Nanotube ◽  
Lorentz Force ◽  
Multi Walled Carbon Nanotube ◽  
Hybrid Nanoparticle

scholarly journals A cDNA-dependent scintillation proximity assay for quantifying apolipoprotein A-I

1997 ◽  
Vol 38 (11) ◽  
pp. 2365-2373
Author(s):  
J C Hanselman ◽  
D A Schwab ◽  
T J Rea ◽  
C L Bisgaier ◽  
M E Pape
Keyword(s):  
Scintillation Proximity Assay ◽  
Apolipoprotein A

A novel high drug loading mussel-inspired polydopamine hybrid nanoparticle as a pH-sensitive vehicle for drug delivery

2017 ◽  
Vol 533 (1) ◽  
pp. 73-83 ◽  
Author(s):  
Jie Hou ◽  
Chunlei Guo ◽  
Yuzhi Shi ◽  
Ergang Liu ◽  
Weibing Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Ph Sensitive ◽  
High Drug ◽  
Hybrid Nanoparticle ◽  
High Drug Loading

Metal Conjugated Semiconductor Hybrid Nanoparticle-Based Fluorescence Resonance Energy Transfer

2010 ◽  
Vol 114 (11) ◽  
pp. 4869-4874 ◽  
Author(s):  
Krishna Kanta Haldar ◽  
Tapasi Sen ◽  
Amitava Patra
Keyword(s):  
Energy Transfer ◽  
Fluorescence Resonance Energy Transfer ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Hybrid Nanoparticle ◽  
Fluorescence Resonance

Application of the scintillation proximity assay technique to the determination of drugs

1994 ◽  
Vol 31 (3) ◽  
pp. 103 ◽  
Author(s):  
Susan Fenwick ◽  
William N. Jenner ◽  
Paul Linacre ◽  
Regina M. Rooney ◽  
Stephen A. Wring
Keyword(s):  
Scintillation Proximity Assay ◽  
Assay Technique

PEG–PEI-modified gated N-doped mesoporous carbon nanospheres for pH/NIR light-triggered drug release and cancer phototherapy

2021 ◽  
Author(s):  
Snigdharani Panda ◽  
Chandra Sekhar Bhol ◽  
Sujit Kumar Bhutia ◽  
Sasmita Mohapatra
Keyword(s):  
Drug Release ◽  
Mesoporous Carbon ◽  
Laser Excitation ◽  
Outer Shell ◽  
Carbon Nanospheres ◽  
Nir Light ◽  
Triggered Drug Release ◽  
Hybrid Nanoparticle

A hybrid nanoparticle consisting of N-doped mesoporous carbon nanospheres as core and thermosensitive PEG–PEI as outer shell shows multiple therapeutic actions such as PTT, PDT and NIR sensitive drug release under single 980 nm laser excitation.

A scalable and robust cationic lipid/polymer hybrid nanoparticle platform for mRNA delivery

2021 ◽  
pp. 121314
Author(s):  
Randall A. Meyer ◽  
G. Patrick Hussmann ◽  
Norman C. Peterson ◽  
Jose Luis Santos ◽  
Anthony D. Tuesca
Keyword(s):  
Cationic Lipid ◽  
Polymer Hybrid ◽  
Hybrid Nanoparticle
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