scholarly journals Electrostatics as the Driving Force Behind the Catalytic Function of the Monoamine Oxidase A Enzyme Confirmed by Quantum Computations

ACS Catalysis ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 1231-1240 ◽  
Author(s):  
Alja Prah ◽  
Eric Frančišković ◽  
Janez Mavri ◽  
Jernej Stare
Keyword(s):  
Monoamine Oxidase ◽  
Driving Force ◽  
Monoamine Oxidase A ◽  
Catalytic Function ◽  
Quantum Computations

An electrostatic duel: subtle differences in catalytic performance of monoamine oxidase A and B isoenzymes elucidated at a residue level by quantum computations

2021 ◽  
Author(s):  
Alja Prah ◽  
Janez Mavri ◽  
Jernej Stare
Keyword(s):  
Monoamine Oxidase ◽  
Catalytic Performance ◽  
Residue Level ◽  
Monoamine Oxidase A ◽  
Quantum Computations ◽  
Catalytic Power

The origin of the immense catalytic power of enzymes remains one of the biggest unresolved questions in biochemistry, with electrostatics being one of the main contenders. Herein we report results...

scholarly journals High-dose testosterone treatment reduces monoamine oxidase A levels in the human brain: a preliminary report

2021 ◽  
pp. 105381
Author(s):  
Georg S. Kranz ◽  
Marie Spies ◽  
Chrysoula Vraka ◽  
Ulrike Kaufmann ◽  
Eva-Maria Klebermass ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Human Brain ◽  
Preliminary Report ◽  
Monoamine Oxidase A ◽  
High Dose ◽  
Testosterone Treatment

scholarly journals Inhibition of monoamine oxidase–A activity in rat brain by synthetic hydrazines: Structure-activity relationship (SAR)

2005 ◽  
Vol 20 (3) ◽  
pp. 269-274 ◽  
Author(s):  
Ahsana Dar ◽  
Khalid M. Khan ◽  
Humayun S. Ateeq ◽  
Shagufta Khan ◽  
Shagufta Rahat ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Rat Brain ◽  
Structure Activity Relationship ◽  
Monoamine Oxidase A ◽  
Activity Relationship ◽  
Structure Activity

Monoamine Oxidase A (MAOA) methylation in acrophobia: an epigenetic correlate of therapy response?

2019 ◽  
Vol 29 ◽  
pp. S203-S204
Author(s):  
M. Schiele ◽  
C. Ziegler ◽  
L. Kollert ◽  
A. Katzorke ◽  
D. Gromer ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Therapy Response ◽  
Monoamine Oxidase A

scholarly journals Association between monoamine oxidase A promoter polymorphism and the risk of sudden infant death syndrome: a meta-analysis

2021 ◽  
Author(s):  
Qiaoxia Zhou ◽  
Daoyin Gong ◽  
Yu Zhang ◽  
Feijun Huang
Keyword(s):  
Monoamine Oxidase ◽  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Protective Factor ◽  
Meta Analysis ◽  
Variable Number Tandem Repeat ◽  
Sudden Infant Death ◽  
Monoamine Oxidase A ◽  
Sudden Infant ◽  
Increased Risk

Abstract Introduction The etiology of sudden infant death syndrome (SIDS) remains an unsolved problem. The aim of this meta-analysis is to investigate the potential association between monoamine oxidase A (MAOA) promoter variable number tandem repeat (VNTR) polymorphism and SIDS risk. Methods A systematic review and meta-analysis were conducted on studies from accessible electronic databases. Each VNTR variant was examined in each gender independently by comparing with the pooled results of other alleles. Results A total of six independent case–control studies including 1022 SIDS cases and 1839 controls were enrolled in this meta-analysis. In both of the whole populations and Caucasian populations, male infants with the low-MAOA-expression alleles (2R+3R) were found to exhibit a statistically significant increased risk of SIDS, whereas those with a 4R allele exhibited a reduced risk of SIDS. Besides, an increased risk of SIDS was detected in male Caucasian infants with 2R or 3R alleles. However, none of the allele or genotype variants was associated with SIDS in female victims. Conclusion In male Caucasian infants, the low expression of MAOA promoter VNTR alleles (2R and 3R) is associated with an increased risk of SIDS, and the existence of the 4R allele could be regarded as a protective factor.

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