Leishmania infantum Enhances Migration of Macrophages via a Phosphoinositide 3-Kinase γ-Dependent Pathway

2020 ◽  
Vol 6 (7) ◽  
pp. 1643-1649
Author(s):  
Maria Inês Rocha ◽  
Filipa Dias ◽  
Mariana Resende ◽  
Mafalda Sousa ◽  
Margarida Duarte ◽  
...  
Keyword(s):  
Leishmania Infantum ◽  
Phosphoinositide 3 Kinase ◽  
Migration Of Macrophages ◽  
Dependent Pathway

Activity of melatonin against Leishmania infantum promastigotes by mitochondrial dependent pathway

2014 ◽  
Vol 220 ◽  
pp. 84-93 ◽  
Author(s):  
Ehab Kotb Elmahallawy ◽  
Aroa Jiménez-Aranda ◽  
Antonio Sampedro Martínez ◽  
Javier Rodriguez-Granger ◽  
Miguel Navarro-Alarcón ◽  
...  
Keyword(s):  
Leishmania Infantum ◽  
Dependent Pathway

scholarly journals A Novel Phosphoinositide 3-Kinase-dependent Pathway for Angiotensin II/AT-1 Receptor-mediated Induction of Collagen Synthesis in MES-13 Mesangial Cells

2007 ◽  
Vol 282 (26) ◽  
pp. 18819-18830 ◽  
Author(s):  
Naohiro Yano ◽  
Daisuke Suzuki ◽  
Masayuki Endoh ◽  
Ting C. Zhao ◽  
James F. Padbury ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Collagen Synthesis ◽  
Mesangial Cells ◽  
Phosphoinositide 3 Kinase ◽  
Dependent Pathway

scholarly journals Neuregulin-1 Regulates Cell Adhesion via an ErbB2/Phosphoinositide-3 Kinase/Akt-Dependent Pathway: Potential Implications for Schizophrenia and Cancer

PLoS ONE ◽  
2007 ◽  
Vol 2 (12) ◽  
pp. e1369 ◽  
Author(s):  
Christopher G. Kanakry ◽  
Zhen Li ◽  
Yoko Nakai ◽  
Yoshitatsu Sei ◽  
Daniel R. Weinberger
Keyword(s):  
Cell Adhesion ◽  
Neuregulin 1 ◽  
Phosphoinositide 3 Kinase ◽  
Dependent Pathway

Angiotensin II activates Akt/protein kinase B by an arachidonic acid/redox‐dependent pathway and independent of phosphoinositide 3‐kinase

2001 ◽  
Vol 15 (11) ◽  
pp. 1909-1920 ◽  
Author(s):  
Yves Gorin ◽  
Nam‐Ho Kim ◽  
Denis Feliers ◽  
Basant Bhandari ◽  
Goutam Ghosh Choudhury ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Angiotensin Ii ◽  
Protein Kinase ◽  
Protein Kinase B ◽  
Phosphoinositide 3 Kinase ◽  
Dependent Pathway

scholarly journals VEGF Induces Tie2 Shedding via a Phosphoinositide 3-Kinase/Akt–Dependent Pathway to Modulate Tie2 Signaling

2007 ◽  
Vol 27 (12) ◽  
pp. 2619-2626 ◽  
Author(s):  
Clarence M. Findley ◽  
Melissa J. Cudmore ◽  
Asif Ahmed ◽  
Christopher D. Kontos
Keyword(s):  
Phosphoinositide 3 Kinase ◽  
Dependent Pathway

scholarly journals Activation of NF-κB by Bradykinin through a Gαq- and Gβγ-dependent Pathway That Involves Phosphoinositide 3-Kinase and Akt

2000 ◽  
Vol 275 (32) ◽  
pp. 24907-24914 ◽  
Author(s):  
Ping Xie ◽  
Darren D. Browning ◽  
Nissim Hay ◽  
Nigel Mackman ◽  
Richard D. Ye
Keyword(s):  
Phosphoinositide 3 Kinase ◽  
Dependent Pathway

scholarly journals Insulin Regulates Adipocyte Lipolysis via an Akt-Independent Signaling Pathway

2010 ◽  
Vol 30 (21) ◽  
pp. 5009-5020 ◽  
Author(s):  
Sarah M. Choi ◽  
David F. Tucker ◽  
Danielle N. Gross ◽  
Rachael M. Easton ◽  
Lisa M. DiPilato ◽  
...  
Keyword(s):  
Insulin Action ◽  
Hormone Sensitive Lipase ◽  
Dependent Manner ◽  
Impaired Insulin ◽  
Hormone Sensitive ◽  
Phosphoinositide 3 Kinase ◽  
Impaired Insulin Action ◽  
Differential Phosphorylation ◽  
Dependent Pathway ◽  
Kinase A

ABSTRACT After a meal, insulin suppresses lipolysis through the activation of its downstream kinase, Akt, resulting in the inhibition of protein kinase A (PKA), the main positive effector of lipolysis. During insulin resistance, this process is ineffective, leading to a characteristic dyslipidemia and the worsening of impaired insulin action and obesity. Here, we describe a noncanonical Akt-independent, phosphoinositide-3 kinase (PI3K)-dependent pathway that regulates adipocyte lipolysis using restricted subcellular signaling. This pathway selectively alters the PKA phosphorylation of its major lipid droplet-associated substrate, perilipin. In contrast, the phosphorylation of another PKA substrate, hormone-sensitive lipase (HSL), remains Akt dependent. Furthermore, insulin regulates total PKA activity in an Akt-dependent manner. These findings indicate that localized changes in insulin action are responsible for the differential phosphorylation of PKA substrates. Thus, we identify a pathway by which insulin regulates lipolysis through the spatially compartmentalized modulation of PKA.

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