Piecewise Isothermal Nucleic Acid Testing (PINAT) for Infectious Disease Detection with Sample-to-Result Integration at the Point-of-Care

ACS Sensors ◽  
2021 ◽  
Author(s):  
Saptarshi Banerjee ◽  
Sujay Kumar Biswas ◽  
Nandita Kedia ◽  
Rakesh Sarkar ◽  
Aratrika De ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Nucleic Acid ◽  
Point Of Care ◽  
Disease Detection ◽  
Nucleic Acid Testing

Bridging the gap between development of point-of-care nucleic acid testing and patient care for sexually transmitted infections

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Kuangwen Hsieh ◽  
Johan H. Melendez ◽  
Charlotte A Gaydos ◽  
Jeff Tza-Huei Wang
Keyword(s):  
Nucleic Acid ◽  
Patient Care ◽  
Sexually Transmitted Infections ◽  
Medical Cost ◽  
Point Of Care ◽  
Nucleic Acid Testing ◽  
Cost Burden ◽  
Sexually Transmitted

The rate of sexually transmitted infections (STIs), including the four major curable STIs – chlamydia, gonorrhea, trichomoniasis and, syphilis – continue to increase globally, causing medical cost burden and morbidity...

A fully-integrated and automated testing device for PCR-free viral nucleic acid detection in whole blood

Lab on a Chip ◽  
2018 ◽  
Vol 18 (13) ◽  
pp. 1928-1935 ◽  
Author(s):  
Wenhan Liu ◽  
Jagotamoy Das ◽  
Adam H. Mepham ◽  
Carine R. Nemr ◽  
Edward H. Sargent ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Nucleic Acid ◽  
Disease Diagnosis ◽  
Automated Testing ◽  
Nucleic Acid Detection ◽  
Nucleic Acid Testing ◽  
Testing Device ◽  
Viral Nucleic Acid ◽  
Fully Integrated ◽  
Integrated Devices

Integrated devices for automated nucleic acid testing (NAT) are critical for infectious disease diagnosis to be performed outside of centralized laboratories.

The Standardization and Control of Serology and Nucleic Acid Testing for Infectious Diseases

2021 ◽  
Author(s):  
Wayne Dimech
Keyword(s):  
Infectious Disease ◽  
Nucleic Acid ◽  
Infectious Diseases ◽  
Complement Fixation ◽  
Nucleic Acid Testing ◽  
Biological Functions ◽  
Patient Sample ◽  
Test Systems ◽  
Specific Antigens ◽  
And Control

Historically, the detection of antibodies against infectious disease agents was achieved using test systems that utilized biological functions such as neutralization, complement fixation, hemagglutination, or visualization of binding of antibodies to specific antigens, using testing doubling dilutions of the patient sample to determine an endpoint. These test systems have since been replaced by automated platforms, many of which have been integrated into general medical pathology.

scholarly journals HIV Testing After a First Positive Rapid Diagnostic Test: A Role for Nucleic Acid Testing?

2018 ◽  
Vol 5 (8) ◽  
Author(s):  
Anne M Neilan ◽  
Jennifer E Cohn ◽  
Jean-Francois Lemaire ◽  
Emma Sacks ◽  
Rebecca Alban ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Open Access ◽  
Hiv Testing ◽  
Rapid Diagnostic Test ◽  
Point Of Care ◽  
Preliminary Investigation ◽  
Field Testing ◽  
Nucleic Acid Testing ◽  
Trade Offs ◽  
Testing Algorithms

Abstract We developed an open-access, Excel-based model simulating currently recommended and alternative algorithms for adult HIV testing as a preliminary investigation of trade-offs between accuracy and costs. Despite higher costs, simpler HIV testing algorithms incorporating point of care nucleic acid testing may improve outcomes and thus merit additional research and field testing.

scholarly journals Fluorescence Polarization Based Nucleic Acid Testing for Rapid and Cost-Effective Diagnosis of Infectious Disease

2015 ◽  
Vol 21 (46) ◽  
pp. 16359-16363 ◽  
Author(s):  
Ki Soo Park ◽  
Richelle C. Charles ◽  
Edward T. Ryan ◽  
Ralph Weissleder ◽  
Hakho Lee
Keyword(s):  
Infectious Disease ◽  
Nucleic Acid ◽  
Fluorescence Polarization ◽  
Cost Effective ◽  
Nucleic Acid Testing ◽  
Effective Diagnosis

Polydimethylsiloxane-Paper Hybrid Lateral Flow Assay for Highly Sensitive Point-of-Care Nucleic Acid Testing

2016 ◽  
Vol 88 (12) ◽  
pp. 6254-6264 ◽  
Author(s):  
Jane Ru Choi ◽  
Zhi Liu ◽  
Jie Hu ◽  
Ruihua Tang ◽  
Yan Gong ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Point Of Care ◽  
Lateral Flow ◽  
Lateral Flow Assay ◽  
Nucleic Acid Testing ◽  
Highly Sensitive
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